AutismKB 2.0

Annotation Detail for DUSP11


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Basic Information Top
Gene Symbol:DUSP11 ( PIR1 )
Gene Full Name: dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
Band: 2p13.1
Quick LinksEntrez ID:8446; OMIM: 603092; Uniprot ID:DUS11_HUMAN; ENSEMBL ID: ENSG00000144048; HGNC ID: 3066
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of DUSP11 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of DUSP11 mRNAincreases expression 18648102
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in decreased expression of DUSP11 mRNAdecreases expression 15982314
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of DUSP11 proteinaffects expression 20106945
C103303 alitretinoin alitretinoin results in decreased expression of DUSP11 mRNAdecreases expression 15982314
C006253 pirinixic acid pirinixic acid results in decreased expression of DUSP11 mRNAdecreases expression 17426115
D015474 Isotretinoin Isotretinoin results in decreased expression of DUSP11 mRNAdecreases expression 15982314
C021751 tanshinone tanshinone results in increased expression of DUSP11 mRNAincreases expression 15849732
D014212 Tretinoin Tretinoin metabolite results in decreased expression of DUSP11 mRNAdecreases expression 15982314
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 4.8218769834
MESH:D000015 Abnormalities, Multiple Isotretinoin 5.1818769834
MESH:D017486 Acneiform Eruptions Isotretinoin 6.6016232082
MESH:D000152 Acne Vulgaris Isotretinoin 5.8018769834 16185265
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.863712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D000505 Alopecia Tretinoin 3.7815955085
MESH:D001169 Arthritis, Experimental Tretinoin 3.1916412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001471 Barrett Esophagus Tretinoin 4.6416935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.341440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.6719483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.6716197459 16206674
MESH:D001943 Breast Neoplasms alitretinoin 2.2116344269
MESH:D001943 Breast Neoplasms tanshinone 2.2115849732 19885617
MESH:D001943 Breast Neoplasms Tretinoin 2.2116443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8816813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4816168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8116705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.813581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.8112907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.811917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.767296757
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 5.2411237771
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 5.2416051514 16096774
MESH:D002386 Cataract Tretinoin 3.2017460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.897505956
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8816129372
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.359022650 19486331
MESH:D002779 Cholestasis pirinixic acid 8.3519176532
MESH:D002822 Choriocarcinoma Tretinoin 5.4816461808
MESH:D002972 Cleft Palate Tretinoin 2.749407595
MESH:D003092 Colitis Tretinoin 3.9617035595
MESH:D019465 Craniofacial Abnormalities Isotretinoin 3.1218769834 9879862
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.1210589399 9224671 17551590 9664655 16925845 9142499 9125849 9211117 8800419 14991402
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2718551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0611298694 8156756 8970840 18759878 11906362 12868966 2524372 14531868
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.713621924 2952479
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 4.0218551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.0216192314 9653073 7440962 1440618 18692083 9328219 8291058 6482804 18289764 18648102 9022650 11289319 6679447
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004489 Edema, Cardiac Tretinoin 4.7818230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2316569247
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005124 Eye Abnormalities Tretinoin 3.739664655 16938888
MESH:D005234 Fatty Liver pirinixic acid 2.9719236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D005355 Fibrosis Tretinoin 3.7717994277
MESH:D005909 Glioblastoma Tretinoin 3.1317312396
MESH:D005910 Glioma tanshinone 4.0916955220
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.999664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.756705139
MESH:D006529 Hepatomegaly pirinixic acid 3.2516221962 19176532 19772884 18467677
MESH:D006930 Hyperalgesia Tretinoin 3.3716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.8316778211
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D017379 Hypertrophy, Left Ventricular tanshinone 5.4319662366
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007410 Intestinal Diseases Tretinoin 4.0217994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.348074119 9022650
MESH:D007569 Jaw Abnormalities Tretinoin 4.1117551590 15992940
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.9216144296
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.9416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.946582329
MESH:D007938 Leukemia Tretinoin 2.8617143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9016932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1016294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2816140955 16823087 17506722 17294898 15748426 17649720 16331271 19035177 17301526 19642359 12679006 17712046 17368321 9834237 17217047 16788101 16766008 17107899 19225113 17339181 19029980 16935935 16891316 17361223 19075265
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.459224671
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3115034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3915474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.3916248980 18397230
MESH:D008113 Liver Neoplasms Aflatoxin B1 4.702125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms pirinixic acid 4.7015890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.37598648 3712494 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.378603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.8414755239
MESH:D008175 Lung Neoplasms alitretinoin 3.8416413115
MESH:D008175 Lung Neoplasms Isotretinoin 3.8415899809
MESH:D008527 Medulloblastoma Tretinoin 2.8517453147
MESH:D008545 Melanoma Isotretinoin 3.8217237267
MESH:D008545 Melanoma Tretinoin 3.8216752155
MESH:D008591 Meningomyelocele Tretinoin 4.6816940565
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1917596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.1418551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.543581430
MESH:D009369 Neoplasms alitretinoin 8.8816946489
MESH:D009369 Neoplasms pirinixic acid 8.8817405874
MESH:D009369 Neoplasms Tretinoin 8.8816946489 16594593
MESH:D009421 Nervous System Malformations Tretinoin 4.029125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.656679447
MESH:D009436 Neural Tube Defects Tretinoin 7.659142499
MESH:D009447 Neuroblastoma Isotretinoin 4.1417368321
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.5316049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.536482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4016936753
MESH:D010146 Pain Tretinoin 3.0716870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5215976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D017499 Porokeratosis alitretinoin 6.3216144296
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 5.1718769834
MESH:D011507 Proteinuria Tretinoin 3.8216636307
MESH:D011596 Psychomotor Disorders Isotretinoin 6.2018769834
MESH:D011625 Pterygium Tretinoin 5.0816723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.3216283617 16116481
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6618551238
MESH:D012878 Skin Neoplasms Tretinoin 2.6916467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.667505956 6582329 6587162 1399818 3712494
MESH:D013964 Thyroid Neoplasms Tretinoin 7.6617045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.9816051514
MESH:D014376 Tuberculosis Tretinoin 3.3416040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2416049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.248074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6010091137
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8716129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.9316752155
MESH:D014820 Vitiligo Tretinoin 4.2916761959
MESH:D009396 Wilms Tumor Tretinoin 4.1516287080
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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