AutismKB 2.0

Annotation Detail for FAM120B


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Basic Information Top
Gene Symbol:FAM120B ( CCPG,FLJ55614,KIAA0183,KIAA1838,PGCC1,dJ894D12.1 )
Gene Full Name: family with sequence similarity 120B
Band: 6q27
Quick LinksEntrez ID:84498; OMIM: 612266; Uniprot ID:F120B_HUMAN; ENSEMBL ID: ENSG00000112584; HGNC ID: 21109
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200112RXR and RAR heterodimerization with other nuclear receptor
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of FAM120B mRNAaffects expression 17562736
D003474 Curcumin Curcumin results in decreased expression of FAM120B mRNAdecreases expression 17999991
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of FAM120B mRNAaffects expression 17555576
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of FAM120B mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of FAM120B mRNAincreases expression 19482888
D013629 Tamoxifen Tamoxifen affects the expression of FAM120B mRNAaffects expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.1614745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.986195326
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.5517505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8814692618
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.5117620307
MESH:D019973 Alcohol-Related Disorders Curcumin 5.6917887948
MESH:D000544 Alzheimer Disease Curcumin 2.6715590663
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8615885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.8016807698
MESH:D050197 Atherosclerosis Curcumin 3.5118704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001327 Autoimmune Diseases Curcumin 4.9819761891
MESH:D002545 Brain Ischemia Curcumin 4.8716770732
MESH:D001932 Brain Neoplasms Curcumin 4.2817596214
MESH:D001943 Breast Neoplasms Curcumin 2.3119250217 18593918 18462866 16243823
MESH:D001943 Breast Neoplasms Tamoxifen 2.3116873071 11161223 19200415 19221464 17440819 19066611 21152245 19084267 19115204 19011961 20065188 16202921 18425577 18821012 17049068 15565566 17242785 20135344 19410462 16818667 19487384 15668708 17261762 18815881 16273361 20544844 19059307 19244106 19288272 18997820 20390343 18855134 19289846 19189212 19103187 18351453 20005174 19155303 18984771 19189210 21138602 18629630 20859285 17893378 19142967
MESH:D002277 Carcinoma Curcumin 4.1218593918
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9919066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.793084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.796705139 20935162 20007298 1701930 17173139
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.7916924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0718414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.8418462866
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.9617572228
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.744080065
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1317110522 16919318 15861022 16105132 11677210 17681005 17333356
MESH:D003092 Colitis Curcumin 4.6618200517 16804969 16782535
MESH:D003103 Coloboma Curcumin 4.9218809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5519359593 16340194
MESH:D016510 Corneal Neovascularization Curcumin 5.3818497527
MESH:D003711 Demyelinating Diseases Tamoxifen 4.8519031437
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.7718403477
MESH:D003928 Diabetic Nephropathies Curcumin 10.1618204486
MESH:D003928 Diabetic Nephropathies Tamoxifen 10.1619279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6611743745 15968718 12153990 19739265 11739529 11421492 12540782 10915739 19923254 14986274 15619225 17522070 14550746 11834606 2444490 18071297 10774834 12958197 19370779 11287661 19164858 19416960 11529661 16227642 17562736 19085960 16485898 19420014 12392966 16177239 16393943 16109766 12705907 16081117 16781746 12594235 14725611 11461765 18713872 17906064 10663392
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004381 Duodenal Ulcer Curcumin 4.4917351913
MESH:D004421 Dystonia Phenobarbital 4.411851702
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.4512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.4519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2620544844 17893378 16202921 19155303
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.593659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.4811558140 3922381
MESH:D004827 Epilepsy Phenobarbital 3.0420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.876401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.747750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.563659116
MESH:D005234 Fatty Liver Curcumin 15.4319297423
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.4315345470
MESH:D005234 Fatty Liver Tamoxifen 15.4319224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4316709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 5.0714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.7219069698
MESH:D005355 Fibrosis Curcumin 4.4718705752
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 5.1818462866
MESH:D005909 Glioblastoma Curcumin 3.6917596214
MESH:D006258 Head and Neck Neoplasms Curcumin 3.8818462866 18829502
MESH:D006529 Hepatomegaly Phenobarbital 3.9716109766
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.5217701891
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006937 Hypercholesterolemia Curcumin 4.4318704882
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2916945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7117937319
MESH:D007249 Inflammation Curcumin 5.8116956363 18403477 17151092
MESH:D007249 Inflammation Tamoxifen 5.8119457130
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.3218200517 18596194
MESH:D007414 Intestinal Neoplasms Curcumin 4.5710783313
MESH:D007674 Kidney Diseases Acetaminophen 2.3815629191 12587719
MESH:D007680 Kidney Neoplasms Tamoxifen 3.3518625569
MESH:D007889 Leiomyoma Curcumin 4.9818555241
MESH:D007938 Leukemia Curcumin 3.3918462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.5816106398
MESH:D015458 Leukemia, T-Cell Curcumin 5.2016106398
MESH:D008064 Lipidoses Tamoxifen 3.4015342952 17567588
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0721047994
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 2.7518006644 18705752 17355460
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.7518564211
MESH:D008107 Liver Diseases Acetaminophen 6.9916611625 12969438 11587558 19784758 12587719 19014921 19460945 16610002
MESH:D008107 Liver Diseases Curcumin 6.9916956363
MESH:D008107 Liver Diseases Phenobarbital 6.9919363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5816871587 17185352
MESH:D008113 Liver Neoplasms Phenobarbital 4.9819812893 19073162 8742319 21047994 19482888 15975961
MESH:D008113 Liver Neoplasms Tamoxifen 4.9816684651
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.906150874 17172636 18308698 1399818 2563599
MESH:D008175 Lung Neoplasms Curcumin 2.7116243823 19359593 18462866
MESH:D008175 Lung Neoplasms Tamoxifen 2.7118625569
MESH:D008223 Lymphoma Curcumin 3.8318462866
MESH:D016399 Lymphoma, T-Cell Curcumin 5.1816173963
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.3019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8311731420 19196723 14580682 19196722 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 5.1619453300
MESH:D008545 Melanoma Curcumin 3.6117885582 18462866
MESH:D008545 Melanoma Tamoxifen 3.6119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.7215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D008569 Memory Disorders Curcumin 4.5917263510
MESH:D009101 Multiple Myeloma Curcumin 3.7619372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.4617962980
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 5.0217484760
MESH:D009361 Neoplasm Invasiveness Curcumin 4.8118495463
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 12.9712497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 12.9719189210 19196722 19200415
MESH:D009423 Nervous System Neoplasms Curcumin 6.2418462866
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D009765 Obesity Curcumin 2.8119297423
MESH:D010018 Osteomalacia Phenobarbital 4.9017016548
MESH:D010024 Osteoporosis Curcumin 3.6718719352
MESH:D010051 Ovarian Neoplasms Curcumin 2.9019020741 18462866
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010190 Pancreatic Neoplasms Curcumin 5.8019196508 17440100 19401701
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.8016965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0911578682
MESH:D011230 Precancerous Conditions Phenobarbital 3.952563599
MESH:D011471 Prostatic Neoplasms Curcumin 3.3211398177 12497104 15129424 18156803 18226269 10851300 18769126
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.3215067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.8515861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 5.1112752131
MESH:D011656 Pulmonary Emphysema Curcumin 4.8819168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.4310666014 18379247
MESH:D012509 Sarcoma Curcumin 4.4618462866
MESH:D012640 Seizures Phenobarbital 2.923137016 11442880 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.366407741
MESH:D018805 Sepsis Curcumin 4.3818389075
MESH:D013088 Spermatocele Ethinyl Estradiol 13.6916709447
MESH:D013088 Spermatocele Tamoxifen 13.6916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5819457130
MESH:D013276 Stomach Ulcer Curcumin 3.8616631530 19188055
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4815669648
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.321399818
MESH:D001749 Urinary Bladder Neoplasms Curcumin 5.6418593936
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.6416712894 8653321 17572228
MESH:D014565 Urogenital Neoplasms Curcumin 5.8018462866
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.7414692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9114671159 15869587
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134920525
    • No data
    No data
    Releated drug ID Related drug Name
    PA451746tretinoin
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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