Annotation Detail for MCM8
Basic Information
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| Gene Symbol: | MCM8 ( C20orf154,MGC119522,MGC119523,MGC12866,MGC4816,REC,dJ967N21.5 ) |
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| Gene Full Name: | minichromosome maintenance complex component 8 |
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| Band: | 20p12.3 |
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| Quick Links | Entrez ID:84515; OMIM: 608187; Uniprot ID:MCM8_HUMAN; ENSEMBL ID: ENSG00000125885; HGNC ID: 16147 |
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| Relate to Another Database: |
SFARIGene;
denovo-db |
| Pathway ID | Pathway Name |
|---|
| Cell Cycle, Mitotic |
| DNA Replication |
| Cell Cycle Checkpoints |
| Pathway ID | Pathway Name |
|---|
| 500377 | Unwinding of DNA |
| Desease Name |
|---|
| menopause (age at onset) |
| menarche and menopause (age at onset) |
| REPRODUCTION |
| Desease Name |
|---|
| Menopause (age at onset) |
| HIV-1 control |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D001104 |
Arbutin |
Arbutin results in increased expression of MCM8 mRNA | increases expression | 17103032
|
| D001564 |
Benzo(a)pyrene |
Benzo(a)pyrene results in decreased expression of MCM8 mRNA | decreases expression | 20064835
|
| D015123 |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MCM8 mRNA | decreases expression | 20018196
|
| D016572 |
Cyclosporine |
Cyclosporine results in decreased expression of MCM8 mRNA | decreases expression | 20106945
|
| C006253 |
pirinixic acid |
pirinixic acid results in increased expression of MCM8 mRNA | increases expression | 17950772
|
| C006253 |
pirinixic acid |
PPARA protein promotes the reaction [pirinixic acid results in increased expression of MCM8 mRNA] | increases expression|increases reaction | 17950772
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D055371 |
Acute Lung Injury |
|
pirinixic acid |
3.52 | 18653653 |
| MESH:D000230 |
Adenocarcinoma |
|
Benzo(a)pyrene |
2.05 | 20127859 20464547 |
| MESH:D000236 |
Adenoma |
|
Benzo(a)pyrene |
2.84 | 6695378 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
pirinixic acid |
4.02 | 16434500 |
| MESH:D017544 |
Aortic Aneurysm, Abdominal |
|
Benzo(a)pyrene |
4.56 | 19183758 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
pirinixic acid |
3.52 | 19483382 |
| MESH:D001943 |
Breast Neoplasms |
|
Benzo(a)pyrene |
2.00 | 20146248 17474063 |
| MESH:D002294 |
Carcinoma, Squamous Cell |
|
Benzo(a)pyrene |
2.13 | 20419170 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
7.35 | 20889678 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
Cyclosporine |
7.35 | 12371664 |
| MESH:D002779 |
Cholestasis |
|
Cyclosporine |
8.63 | 19486331 |
| MESH:D002779 |
Cholestasis |
|
pirinixic acid |
8.63 | 19176532 |
| MESH:D003876 |
Dermatitis, Atopic |
|
pirinixic acid |
2.56 | 18249437 |
| MESH:D004487 |
Edema |
|
pirinixic acid |
2.85 | 12083418 |
| MESH:D004938 |
Esophageal Neoplasms |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
4.59 | 20426865 |
| MESH:D004938 |
Esophageal Neoplasms |
|
Benzo(a)pyrene |
4.59 | 16530937 |
| MESH:D005234 |
Fatty Liver |
|
Cyclosporine |
8.82 | 19224547 |
| MESH:D005234 |
Fatty Liver |
|
pirinixic acid |
8.82 | 19236843 20131406 |
| MESH:D005355 |
Fibrosis |
|
Cyclosporine |
3.62 | 12639820 12168785 |
| MESH:D005885 |
Gingival Hyperplasia |
|
Cyclosporine |
4.76 | 8708960 |
| MESH:D006330 |
Heart Defects, Congenital |
|
Benzo(a)pyrene |
2.82 | 20471113 |
| MESH:D006333 |
Heart Failure |
|
pirinixic acid |
2.73 | 20558911 |
| MESH:D006457 |
Hemoglobinuria, Paroxysmal |
|
Cyclosporine |
4.96 | 15720958 |
| MESH:D006529 |
Hepatomegaly |
|
pirinixic acid |
3.48 | 16221962 19772884 19176532 18467677 |
| MESH:D006943 |
Hyperglycemia |
|
pirinixic acid |
3.53 | 20558911 |
| MESH:D006973 |
Hypertension |
|
Cyclosporine |
2.20 | 10903974 |
| MESH:D007333 |
Insulin Resistance |
|
pirinixic acid |
2.85 | 16306350 |
| MESH:D007638 |
Keratoconjunctivitis Sicca |
|
Cyclosporine |
5.05 | 15604871 |
| MESH:D007674 |
Kidney Diseases |
|
Cyclosporine |
2.52 | 18776723 10903974 8314463 |
| MESH:D007680 |
Kidney Neoplasms |
|
Cyclosporine |
3.04 | 12371664 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
pirinixic acid |
1.35 | 15474484 |
| MESH:D008113 |
Liver Neoplasms |
|
Benzo(a)pyrene |
4.73 | 20195826 21137059 |
| MESH:D008113 |
Liver Neoplasms |
|
pirinixic acid |
4.73 | 20007298 15890375 16377806 |
| MESH:D008175 |
Lung Neoplasms |
|
Benzo(a)pyrene |
1.57 | 18569708 20064080 18816296 20135361 20869020 6695378 17053015 18520028 20464547 |
| MESH:D008664 |
Metal Metabolism, Inborn Errors |
|
Cyclosporine |
5.40 | 16801185 |
| MESH:D009062 |
Mouth Neoplasms |
|
Benzo(a)pyrene |
3.46 | 16381670 |
| MESH:D009135 |
Muscular Diseases |
|
pirinixic acid |
3.99 | 16239165 |
| MESH:D009203 |
Myocardial Infarction |
|
pirinixic acid |
2.26 | 19151258 |
| MESH:D015428 |
Myocardial Reperfusion Injury |
|
pirinixic acid |
3.22 | 16411023 |
| MESH:D009369 |
Neoplasms |
|
Benzo(a)pyrene |
5.33 | 11141357 |
| MESH:D009369 |
Neoplasms |
|
pirinixic acid |
5.33 | 17405874 |
| MESH:D009402 |
Nephrosis, Lipoid |
|
Cyclosporine |
5.05 | 17954296 |
| MESH:D009404 |
Nephrotic Syndrome |
|
Cyclosporine |
3.61 | 18481113 19348381 |
| MESH:D009765 |
Obesity |
|
pirinixic acid |
1.88 | 20558911 |
| MESH:D011230 |
Precancerous Conditions |
|
Cyclosporine |
3.55 | 12371664 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Benzo(a)pyrene |
2.91 | 17292933 |
| MESH:D011565 |
Psoriasis |
|
Cyclosporine |
2.32 | 16882103 |
| MESH:D015427 |
Reperfusion Injury |
|
pirinixic acid |
2.53 | 19058328 |
| MESH:D012878 |
Skin Neoplasms |
|
Benzo(a)pyrene |
2.51 | 10029692 19755658 |
| MESH:D013274 |
Stomach Neoplasms |
|
Benzo(a)pyrene |
1.56 | 20155912 2093021 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
Benzo(a)pyrene |
2.29 | 17053015 |
| MESH:D014605 |
Uveitis |
|
Cyclosporine |
4.59 | 1336536 |
| MESH:D014985 |
Xerophthalmia |
|
Cyclosporine |
5.05 | 17120751 |
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