AutismKB 2.0

Annotation Detail for ACRBP


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Basic Information Top
Gene Symbol:ACRBP ( CT23,FLJ51160,OY-TES-1,SP32 )
Gene Full Name: acrosin binding protein
Band: 12p13.31
Quick LinksEntrez ID:84519; OMIM: 608352; Uniprot ID:ACRBP_HUMAN; ENSEMBL ID: ENSG00000111644; HGNC ID: 17195
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ACRBP mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ACRBP mRNAincreases expression 20504355
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of ACRBP mRNAdecreases expression 17555576
D007213 Indomethacin Indomethacin results in increased expression of ACRBP mRNAincreases expression 16984733
D013629 Tamoxifen Tamoxifen affects the expression of ACRBP mRNAaffects expression 17555576
D014212 Tretinoin Tretinoin results in increased expression of ACRBP mRNAincreases expression 16604517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.0714745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.4820127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.4814692618
MESH:D000230 Adenocarcinoma Indomethacin 7.4816537180
MESH:D000236 Adenoma Benzo(a)pyrene 7.416695378
MESH:D000236 Adenoma Indomethacin 7.4111497255
MESH:D000505 Alopecia Tretinoin 3.8715955085
MESH:D016301 Alveolar Bone Loss Indomethacin 5.8917225004
MESH:D000544 Alzheimer Disease Indomethacin 2.7617627676 15579461
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001014 Aortic Aneurysm Indomethacin 5.2310231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 13.1419183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 13.1410388637
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D018771 Arthralgia Indomethacin 5.692160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.8015885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.8016412693
MESH:D001172 Arthritis, Rheumatoid Indomethacin 4.9711248219
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.9716292516
MESH:D001249 Asthma Tretinoin 2.4216456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001471 Barrett Esophagus Tretinoin 4.7816935849
MESH:D001477 Bartter Syndrome Indomethacin 5.4010684365
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.9316197459 16206674
MESH:D001929 Brain Edema Indomethacin 5.5511481608
MESH:D002545 Brain Ischemia Indomethacin 4.8812524144
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0120146248 17474063
MESH:D001943 Breast Neoplasms Indomethacin 2.0117401462
MESH:D001943 Breast Neoplasms Tamoxifen 2.0118815881 20005174 20544844 18984771 19011961 20390343 19221464 16818667 19410462 20065188 16202921 19200415 15565566 19289846 19115204 17261762 19189212 21152245 19084267 19103187 16873071 19487384 17440819 19288272 19189210 18997820 15668708 18425577 21138602 18821012 17893378 17242785 17049068 20859285 19142967 19066611 19244106 19155303 18855134 18351453 11161223 16273361 20135344 18629630 19059307
MESH:D001943 Breast Neoplasms Tretinoin 2.0116443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.0516813970
MESH:D002056 Burns Indomethacin 5.1210459503
MESH:D002100 Cachexia Indomethacin 5.4715141370 15625704 11239499 16537180
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9219066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6816168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.923084413
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 6.9216391822
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.9216924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.921917145
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 5.1911053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.8118791128 14736730 11352223
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.5017341418
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 8.0220419170
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 8.0212636206 15482327
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 8.0216096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.9217572228
MESH:D002386 Cataract Acetaminophen 7.7810977129
MESH:D002386 Cataract Tretinoin 7.7817460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.0516129372
MESH:D002764 Cholecystitis Indomethacin 5.6911181007
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1016105132 11677210 16919318 17110522 17681005 15861022 17333356
MESH:D002822 Choriocarcinoma Tretinoin 5.6816461808
MESH:D002972 Cleft Palate Tretinoin 2.789407595
MESH:D003092 Colitis Tretinoin 4.1217035595
MESH:D003110 Colonic Neoplasms Indomethacin 2.6315936596 15786552 11260862 15625704 15637740 15963497
MESH:D015179 Colorectal Neoplasms Indomethacin 2.3617054584 12606626 18059344 11197048
MESH:D018352 Coronavirus Infections Indomethacin 6.2417302372
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.839142499 8800419 9224671 9125849 9211117 9664655 10589399 14991402 17551590 16925845
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7819031437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7619279558
MESH:D003967 Diarrhea Indomethacin 4.177237001 7907874
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6516393943 12594235 19420014 16227642 12392966 19085960 11529661 17522070 16485898 12958197 10774834 11834606 10663392 11421492 17562736 2444490 19370779 14986274 14550746 19923254 15619225 19164858 12540782 15968718 12153990 16177239 17906064 18071297 12705907 16081117 16109766 11743745 18713872 11739529 11461765 11287661 19739265 19416960 14725611 16781746 10915739
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.6118446180 12774134 16326151 16133044 17190690 18043480
MESH:D004381 Duodenal Ulcer Indomethacin 4.5217351913 17202747 16699067 11595431 11595415 10671773 11991626 17329845 11535926 17045617 17151854
MESH:D004487 Edema Indomethacin 3.828273558 16100529 7990266 7907874 19703484 10653021 8985016
MESH:D004489 Edema, Cardiac Tretinoin 4.9918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.2412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.2419031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 8.0816202921 19155303 17893378 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 8.0816569247
MESH:D004715 Endometriosis Indomethacin 4.4515652904
MESH:D019446 Endotoxemia Indomethacin 4.9618509659
MESH:D004751 Enteritis Indomethacin 5.2710567023 17763956 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 5.4017980183
MESH:D004802 Eosinophilia Indomethacin 4.4711298111
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.8416530937
MESH:D004938 Esophageal Neoplasms Indomethacin 4.8411005569
MESH:D005124 Eye Abnormalities Tretinoin 3.819664655 16938888
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.7915345470
MESH:D005234 Fatty Liver Tamoxifen 8.7919224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4116709447
MESH:D005334 Fever Indomethacin 4.4211852909 10431976 17627676
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.6419069698
MESH:D005354 Fibrosarcoma Indomethacin 5.3610962813
MESH:D005355 Fibrosis Indomethacin 10.4617994277
MESH:D005355 Fibrosis Tretinoin 10.4617994277
MESH:D005499 Folliculitis Indomethacin 5.6911298111
MESH:D005756 Gastritis Acetaminophen 12.9516983495
MESH:D005756 Gastritis Indomethacin 12.9515046732
MESH:D005909 Glioblastoma Indomethacin 7.9712870263
MESH:D005909 Glioblastoma Tretinoin 7.9717312396
MESH:D005910 Glioma Indomethacin 3.3316487511 18371953
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.5411849393
MESH:D006073 Gout Indomethacin 5.8111248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 8.6015482327
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.6016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6816084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 7.1420471113
MESH:D006330 Heart Defects, Congenital Tretinoin 7.1414991402 9664655
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.9015633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 5.0615135802
MESH:D006930 Hyperalgesia Acetaminophen 14.5916870215
MESH:D006930 Hyperalgesia Indomethacin 14.5912727271
MESH:D006930 Hyperalgesia Tretinoin 14.5916870215
MESH:D034321 Hyperamylasemia Indomethacin 6.2417883296
MESH:D006940 Hyperemia Indomethacin 5.4712524144
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9916778211
MESH:D006949 Hyperlipidemias Indomethacin 4.5117546600
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316569931 16945680
MESH:D007077 Ileal Diseases Indomethacin 5.5518306037 10574470
MESH:D007079 Ileitis Indomethacin 5.8110651667 16133968 10647630
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.8916133044
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6817937319
MESH:D007249 Inflammation Indomethacin 5.797812673 3291741 12568917
MESH:D007249 Inflammation Tamoxifen 5.7919457130
MESH:D007410 Intestinal Diseases Indomethacin 11.3117994277 18236018 17329856 15610444 11713966 10210152 15831440 11855677 11686837
MESH:D007410 Intestinal Diseases Tretinoin 11.3117994277
MESH:D019586 Intracranial Hypertension Indomethacin 5.8915241188
MESH:D007569 Jaw Abnormalities Tretinoin 4.2317551590 15992940
MESH:D007579 Jejunal Diseases Indomethacin 5.5516133968 10574470 18306037
MESH:D007674 Kidney Diseases Acetaminophen 6.6912587719 15629191
MESH:D007674 Kidney Diseases Indomethacin 6.6917190690
MESH:D007680 Kidney Neoplasms Tamoxifen 3.3118625569
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 4.1712228301 11703811 10320625
MESH:D007938 Leukemia Tretinoin 2.9017143497
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 4.1510785260 16572323 15631656
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0216932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 4.2218360721
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.2216294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3417712046 17649720 17217047 16935935 16766008 16788101 19642359 19075265 15748426 19225113 17368321 17361223 9834237 17339181 16331271 16891316 17107899 17294898 19035177 19029980 16140955 17301526 12679006 16823087 17506722
MESH:D007964 Leukocytosis Indomethacin 5.8916537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 6.2417980183
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.539224671
MESH:D008064 Lipidoses Tamoxifen 3.3717567588 15342952
MESH:D008101 Liver Abscess, Amebic Indomethacin 6.2411479899
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 3.7618194892
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.7618564211
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.7618397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.6912969438 11587558 16611625 19460945 12587719 19784758 19014921 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.8420195826 21137059
MESH:D008113 Liver Neoplasms Tamoxifen 4.8416684651
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.6518569708 18520028 18816296 17053015 6695378 20464547 20135361 20064080 20869020
MESH:D008175 Lung Neoplasms Indomethacin 3.6511497255 11053908 16537180
MESH:D008175 Lung Neoplasms Tamoxifen 3.6518625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.2219428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8114580682 16827153 11731420 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 5.0719453300
MESH:D008527 Medulloblastoma Tretinoin 2.8817453147
MESH:D008545 Melanoma Tamoxifen 3.4212393984 19393235
MESH:D008545 Melanoma Tretinoin 3.4216752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.6415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D008591 Meningomyelocele Tretinoin 4.8416940565
MESH:D008881 Migraine Disorders Indomethacin 3.8911903285
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.4816381670
MESH:D009062 Mouth Neoplasms Indomethacin 9.4812636206
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2417596541
MESH:D009362 Neoplasm Metastasis Indomethacin 6.3016537180 11239499 11053908
MESH:D009362 Neoplasm Metastasis Tamoxifen 6.3019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009369 Neoplasms Benzo(a)pyrene 5.4511141357
MESH:D009369 Neoplasms Tretinoin 5.4516946489 16594593
MESH:D009374 Neoplasms, Experimental Indomethacin 4.5515625704 10663608
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.5219200415 19196722 19189210
MESH:D009421 Nervous System Malformations Tretinoin 4.169125849
MESH:D009436 Neural Tube Defects Tretinoin 3.249142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 9.3118514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 9.3112349958
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.696374098
MESH:D010003 Osteoarthritis Indomethacin 3.847009135
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4216936753
MESH:D010146 Pain Acetaminophen 12.8716870215
MESH:D010146 Pain Indomethacin 12.8713679232 17440234 3291741 17627676
MESH:D010146 Pain Tretinoin 12.8716870215
MESH:D010149 Pain, Postoperative Indomethacin 5.2012538197 18702446
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5515976015
MESH:D010195 Pancreatitis Indomethacin 4.2715028970 17883296
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D010257 Paraneoplastic Syndromes Indomethacin 6.2416537180
MESH:D020734 Parkinsonian Disorders Indomethacin 4.4212349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 6.2411903285
MESH:D010437 Peptic Ulcer Indomethacin 5.6111148446
MESH:D010518 Periodontitis Indomethacin 5.4317225004
MESH:D047928 Premature Birth Indomethacin 5.5517000239
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0617292933
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.0615067354
MESH:D011507 Proteinuria Indomethacin 10.5311849393
MESH:D011507 Proteinuria Tretinoin 10.5316636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.7715861022 16919318
MESH:D011625 Pterygium Tretinoin 5.2616723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4516283617 16116481
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.1119755658 10029692
MESH:D012878 Skin Neoplasms Tretinoin 6.1116467112
MESH:D013088 Spermatocele Ethinyl Estradiol 13.3616709447
MESH:D013088 Spermatocele Tamoxifen 13.3616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5019457130
MESH:D013272 Stomach Diseases Indomethacin 4.8810215738 10192188 10486359 16113693 17160473 17638125 18209964 16280098 17207306 18545984 15472012 15038085 16184426
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.542093021 20155912
MESH:D013274 Stomach Neoplasms Indomethacin 3.5415609394
MESH:D013274 Stomach Neoplasms Tretinoin 3.5417261132
MESH:D013276 Stomach Ulcer Indomethacin 3.9016252198 18543354 11595415 15104355 11523592 11906479 11729361 17977527 18299717 16631530 11145282 10423059 18087811 18431645 15138204 16755016 16150113 17627676 12500499 17895592 12498302 10750652 16397915 17135157 12467913 17918041 14567935 11595431 12077510 18193104 16934674 17657623 18726076 12787963 15255614 17654042 18237397 16169175 18209962 18181030 1323529 10878458
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D013964 Thyroid Neoplasms Indomethacin 8.2018791128 14736730 11352223
MESH:D013964 Thyroid Neoplasms Tretinoin 8.2016026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.0916051514
MESH:D014376 Tuberculosis Tretinoin 3.4116040207
MESH:D014456 Ulcer Indomethacin 5.3610574470 17380554
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3417053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.348653321 17572228 16712894
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9816129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6814692618
MESH:D014604 Uveal Neoplasms Tretinoin 5.1316752155
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8715869587 14671159
MESH:D014820 Vitiligo Tretinoin 4.4416761959
MESH:D014839 Vomiting Indomethacin 5.2711897121
MESH:D009396 Wilms Tumor Tretinoin 4.2516287080
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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