AutismKB 2.0

Annotation Detail for CUL3


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Basic Information Top
Gene Symbol:CUL3 ( - )
Gene Full Name: cullin 3
Band: 2q36.2
Quick LinksEntrez ID:8452; OMIM: 603136; Uniprot ID:CUL3_HUMAN; ENSEMBL ID: ENSG00000036257; HGNC ID: 2553
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04120Ubiquitin mediated proteolysis
No data
Pathway IDPathway Name
200064Canonical Wnt signaling pathway
200010Aurora B signaling
200116ATF-2 transcription factor network
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CUL3 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CUL3 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of CUL3 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of CUL3 mRNAincreases expression 20504355
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CUL3 mRNAdecreases expression 19150397
D002117 Calcitriol Calcitriol results in increased expression of CUL3 mRNAincreases expression 16002434
D012643 Selenium Selenium results in decreased expression of CUL3 mRNAdecreases expression 19244175
C017947 sodium arsenite sodium arsenite inhibits the reaction [[CUL3 protein binds to KEAP1 protein] which binds to and results in increased ubiquitination of NFE2L2 protein]affects binding|decreases reaction|increases ubiquitination 16785233
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CUL3 mRNAdecreases expression 18691609
D014810 Vitamin E Vitamin E results in decreased expression of CUL3 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0814514962 15322242 11752688
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.746695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.9615276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.1717306315 16712894
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8517474063 20146248
MESH:D001943 Breast Neoplasms Calcitriol 1.8511237771
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8520435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1516050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7516705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.753084413
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.7517306315 15276417 16507464
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.8220419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 7.8211237771
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.8218572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.886135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.8820889678
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 11.8820056578 19524636
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1612621046 8697196 16354765 15340226 15668235
MESH:D003092 Colitis Selenium 3.9917936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5215322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5219769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.6318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.6318551238
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.5021346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.5018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.5012705907 12958197 16485898 16081117 11529661 10915739 18071297 11287661 12392966 19739265 16393943 11834606 12153990 19416960 14725611 16109766 16781746 14986274 15619225 19085960 14550746 17906064 12540782 16227642 11743745 16177239 18713872 15968718 17562736 12594235 10663392 11421492 11739529 19420014 19370779 2444490 10774834 19164858 11461765 19923254 17522070
MESH:D056486 Drug-Induced Liver Injury Selenium 12.5015131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.5020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:C538011 Eales disease Vitamin E 4.979068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1715322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.1315138306
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4820426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4816530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1620067830
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.9216452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.5920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.5910048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 11.5916080930
MESH:D006333 Heart Failure Selenium 3.1717162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1112621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7516490937 16863852
MESH:D006689 Hodgkin Disease sodium arsenite 3.3012676792
MESH:D019584 Hot Flashes Vitamin E 4.2414716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.318697196 16959395 15340226 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618850075 18670907
MESH:D007248 Infertility, Male sodium arsenite 3.1012646999 15346721
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312200463 12878042
MESH:D007251 Influenza, Human Selenium 11.8616624496
MESH:D007251 Influenza, Human Vitamin E 11.8616624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007674 Kidney Diseases Acetaminophen 10.6115629191 12587719
MESH:D007674 Kidney Diseases sodium arsenite 10.6120008137
MESH:D007674 Kidney Diseases Vitamin E 10.6112488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0616518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.8516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.8516705839
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3812878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.3816169303
MESH:D008107 Liver Diseases Acetaminophen 1.6612587719 16611625 19460945 12969438 11587558 19014921 16610002 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.177678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.1721137059 20195826
MESH:D008113 Liver Neoplasms sodium arsenite 11.1715276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.1716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.072876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.0712151625
MESH:D008171 Lung Diseases sodium arsenite 7.8219095001
MESH:D008171 Lung Diseases Vitamin E 7.8216863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9720869020 18816296 20135361 20464547 6695378 18569708 20064080 18520028 17053015
MESH:D008175 Lung Neoplasms sodium arsenite 4.9719931552 16712894 17306315 15276417 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9719555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 4.9711062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8615318939
MESH:D008545 Melanoma sodium arsenite 2.0519082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008654 Mesothelioma Selenium 2.8515107826
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.1518551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.157678174 18551238
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2811141357
MESH:D009369 Neoplasms sodium arsenite 5.2811559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8820056578
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.2512854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.4312819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.4316049721
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4817306315 15276417
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D010954 Plasmacytoma Selenium 5.1515087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311118676 11896295 11399792 11222880
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.0215572423
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0617292933
MESH:D011471 Prostatic Neoplasms Calcitriol 2.0616289102 16644109 15754350 12479363 18247401
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0616039940
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0615084515
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012640 Seizures 2,4-dinitrotoluene 6.2518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.2518551238
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.8319755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 9.8318572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.8316192470
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9312854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D020521 Stroke Vitamin E 3.6616517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.4216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.4216049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.4217053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 12.4216712894 11723127 17306315 16452187
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.8010091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.8010091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9311813266
MESH:D014652 Vascular Diseases sodium arsenite 4.6617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
Pathway ID Pathway Name
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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