AutismKB 2.0

Annotation Detail for JAGN1


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Basic Information Top
Gene Symbol:JAGN1 ( FLJ14602,GL009 )
Gene Full Name: jagunal homolog 1 (Drosophila)
Band: 3p25.3
Quick LinksEntrez ID:84522; OMIM: NA; Uniprot ID:JAGN1_HUMAN; ENSEMBL ID: ENSG00000171135; HGNC ID: 26926
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of JAGN1 mRNAaffects expression 17555576
C006253 pirinixic acid pirinixic acid results in increased expression of JAGN1 mRNAincreases expression 18301758
D013629 Tamoxifen Tamoxifen affects the expression of JAGN1 mRNAaffects expression 17555576
C066340 tolcapone tolcapone binds to JAGN1 proteinaffects binding 19783845
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.2714745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.6617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.5818653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8814692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.1116434500
MESH:D017109 Akathisia, Drug-Induced tolcapone 7.0211080934
MESH:D000544 Alzheimer Disease tolcapone 3.3420150427
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 4.0211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8915885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5719483382
MESH:D001943 Breast Neoplasms Tamoxifen 2.1719103187 19221464 16273361 19155303 19244106 17893378 15668708 18855134 17049068 19189210 20859285 16202921 17242785 20135344 19288272 15565566 19066611 20544844 19487384 19142967 16873071 19011961 20065188 11161223 21138602 18629630 19289846 19115204 17261762 19084267 21152245 18815881 18821012 18351453 19200415 19189212 18997820 19059307 20005174 18984771 17440819 16818667 20390343 19410462 18425577
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 5.0719066611
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 1.8616924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 4.0117572228
MESH:D002779 Cholestasis Ethinyl Estradiol 8.7316919318 17110522 17681005 15861022 16105132 11677210 17333356
MESH:D002779 Cholestasis pirinixic acid 8.7319176532
MESH:D003711 Demyelinating Diseases Tamoxifen 4.9219031437
MESH:D003866 Depressive Disorder tolcapone 4.5811224284 7768276
MESH:D003865 Depressive Disorder, Major tolcapone 5.2710440460
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5718249437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.8419279558
MESH:D056486 Drug-Induced Liver Injury tolcapone 3.3119783845 16604736
MESH:D004409 Dyskinesia, Drug-Induced tolcapone 6.1211455177
MESH:D004487 Edema pirinixic acid 2.9012083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.6812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.6819031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2917893378 19155303 20544844 16202921
MESH:D054908 Extensively Drug-Resistant Tuberculosis tolcapone 6.6719578428
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.6415345470
MESH:D005234 Fatty Liver pirinixic acid 15.6420131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 15.6419224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4516709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 5.1614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.8119069698
MESH:D006333 Heart Failure pirinixic acid 2.7620558911
MESH:D006529 Hepatomegaly pirinixic acid 3.5519176532 16221962 19772884 18467677
MESH:D006943 Hyperglycemia pirinixic acid 3.5820558911
MESH:D007021 Hypospadias Ethinyl Estradiol 4.3716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.9212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7317937319
MESH:D007249 Inflammation Tamoxifen 2.5319457130
MESH:D007333 Insulin Resistance pirinixic acid 2.8716306350
MESH:D007680 Kidney Neoplasms Tamoxifen 3.3818625569
MESH:D008064 Lipidoses Tamoxifen 3.4315342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4115474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.4118564211
MESH:D008113 Liver Neoplasms pirinixic acid 4.8420007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 4.8416684651
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.3919428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8611731420 19196723 14580682 16827153 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 5.2719453300
MESH:D008545 Melanoma Tamoxifen 1.9219393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.8115990972
MESH:D009135 Muscular Diseases pirinixic acid 4.0716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2516411023
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6119410462
MESH:D009369 Neoplasms pirinixic acid 2.1117405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.7219189210 19196722 19200415
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.1511578682
MESH:D010300 Parkinson Disease tolcapone 3.7111746615 9305320 11586115 8635184 20334432 1977408 17089403 20216409 18328768 9708959 9333106 16758261 11793426 9591521 9754991 11432539 7566641 10651109 19578428 19783845 8739811
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.0915067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.9415861022 16919318
MESH:D015427 Reperfusion Injury pirinixic acid 2.5519058328
MESH:D013088 Spermatocele Ethinyl Estradiol 14.1116709447
MESH:D013088 Spermatocele Tamoxifen 14.1116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.6719457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.5215669648
MESH:D018088 Tuberculosis, Multidrug-Resistant tolcapone 6.6719578428
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.488653321 17572228 16712894
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.8014692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9714671159 15869587
MESH:D014820 Vitiligo tolcapone 5.7010573327
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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