AutismKB 2.0

Annotation Detail for HOPX


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Basic Information Top
Gene Symbol:HOPX ( CAMEO,HOD,HOP,LAGY,MGC20820,NECC1,OB1,SMAP31,TOTO )
Gene Full Name: HOP homeobox
Band: 4q12
Quick LinksEntrez ID:84525; OMIM: 607275; Uniprot ID:HOP_HUMAN; ENSEMBL ID: ENSG00000171476; HGNC ID: 24961
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of HOPX mRNAdecreases expression 19933214
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of HOPX mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of HOPX mRNAdecreases expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of HOPX mRNAaffects expression 21346803
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of HOPX proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HOPX mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of HOPX mRNAincreases expression 20106945
D003474 Curcumin Curcumin results in increased expression of HOPX mRNAincreases expression 18299980
D016572 Cyclosporine Cyclosporine results in increased expression of HOPX mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of HOPX mRNAincreases expression 18042831
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of HOPX mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of HOPX mRNAdecreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of HOPX mRNAincreases expression 20106945
C041786 palm oil palm oil results in increased expression of HOPX mRNAincreases expression 18042831
C006253 pirinixic acid pirinixic acid results in decreased expression of HOPX mRNAdecreases expression 17426115
C006253 pirinixic acid pirinixic acid results in increased expression of HOPX mRNAincreases expression 18301758
C025299 polyphenols polyphenols results in decreased expression of HOPX mRNAdecreases expression 16293270
D011374 Progesterone Progesterone affects the expression of HOPX mRNAaffects expression 17251523
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of HOPX mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HOPX mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HOPX mRNAdecreases expression 19933214
D014212 Tretinoin Tretinoin results in increased expression of HOPX mRNAincreases expression 16249480
C025643 vinclozolin vinclozolin affects the expression of HOPX mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 8.367525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.3611752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.5218287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.0818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2520127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.2511473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.513712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.516695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.7816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.7816835633
MESH:D019973 Alcohol-Related Disorders Curcumin 5.0517887948
MESH:D000505 Alopecia Tretinoin 3.5815955085
MESH:D000544 Alzheimer Disease Curcumin 2.6115590663
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9111748828
MESH:D001008 Anxiety Disorders vinclozolin 3.6019015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0319183758
MESH:D001161 Arteriosclerosis Dietary Fats 3.8515238619
MESH:D001169 Arthritis, Experimental Tretinoin 3.0516412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.7016807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.7016292516
MESH:D001249 Asthma Tretinoin 2.3316456186
MESH:D050197 Atherosclerosis Curcumin 3.2918704882
MESH:D001327 Autoimmune Diseases Curcumin 4.4519761891
MESH:D001471 Barrett Esophagus Tretinoin 4.3616935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.9911289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.0412125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.0416206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7315746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.3117868700
MESH:D001930 Brain Injuries Progesterone 4.2215665606 15845082 15380490
MESH:D002545 Brain Ischemia Curcumin 4.2916770732
MESH:D001932 Brain Neoplasms Curcumin 3.9017596214
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.7520146248 17474063
MESH:D001943 Breast Neoplasms Curcumin 3.7518462866 19250217 16243823 18593918
MESH:D001943 Breast Neoplasms Dietary Fats 3.7520435547
MESH:D001943 Breast Neoplasms Estradiol 3.7516675129 17289903 17018787 12948864 14630087 17261762 18497071 19861407
MESH:D001943 Breast Neoplasms Progesterone 3.7517614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.7520435547
MESH:D001943 Breast Neoplasms Tretinoin 3.7516166294 16873071 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5516813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4316111702
MESH:D002277 Carcinoma Curcumin 8.1618593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.1616835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1316168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.8016705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.803581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 8.8021507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.8016924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.801917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.9618414057
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.657296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.4920419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 7.4918462866
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.4916051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3418670907 18850075 16120746
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.5214694615
MESH:D002386 Cataract Tretinoin 7.5217460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 10.967505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.9612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.9618566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5516129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.1919486331 9022650
MESH:D002779 Cholestasis Cyclosporine 13.1919486331
MESH:D002779 Cholestasis pirinixic acid 13.1919176532
MESH:D002822 Choriocarcinoma Tretinoin 5.1316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.708697196 12621046 15340226 15668235 16354765
MESH:D002972 Cleft Palate Tretinoin 5.709407595
MESH:D003092 Colitis Curcumin 9.5116782535 16804969 18200517
MESH:D003092 Colitis Tretinoin 9.5117035595
MESH:D003103 Coloboma Curcumin 4.5118809619
MESH:D003110 Colonic Neoplasms Curcumin 4.0719359593 16340194
MESH:D003110 Colonic Neoplasms polyphenols 4.0716293270
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.0615095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.0614669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.8618497527
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4310048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.4314991402 17551590 9664655 10589399 9211117 16925845 9142499 9125849 8800419 9224671
MESH:D003456 Cryptorchidism vinclozolin 4.3014966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.9718551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7712868966 2524372 18759878 14531868 8156756 11906362 8970840 11298694
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4018249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.452952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.3718403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3717107852
MESH:D003928 Diabetic Nephropathies Curcumin 8.9118204486
MESH:D003928 Diabetic Nephropathies Estradiol 8.9119279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.4517187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 11.9018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 11.909328219 7440962 1440618 9653073 9022650 8291058 18692083 6679447 18289764 16192314 11289319 18648102 6482804
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 11.9021346803
MESH:D056486 Drug-Induced Liver Injury polyphenols 11.9019370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.9020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7311462148
MESH:D004381 Duodenal Ulcer Curcumin 4.0117351913
MESH:D050171 Dyslipidemias Dietary Fats 3.4218367378
MESH:D004487 Edema pirinixic acid 6.4012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.4012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.8515322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.8518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.7417692515
MESH:D016889 Endometrial Neoplasms Estradiol 7.3211473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 7.3216569247
MESH:D004715 Endometriosis Progesterone 8.8016134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.8010568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.323581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3216530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.7211564622
MESH:D005124 Eye Abnormalities Tretinoin 8.7216938888 9664655
MESH:D005234 Fatty Liver Curcumin 18.4519297423
MESH:D005234 Fatty Liver Cyclosporine 18.4519224547
MESH:D005234 Fatty Liver Dietary Fats 18.4517967931 19004024 19551842 18296743
MESH:D005234 Fatty Liver pirinixic acid 18.4519236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.996705139
MESH:D005355 Fibrosis Curcumin 27.3518705752
MESH:D005355 Fibrosis Cyclosporine 27.3512168785 12639820
MESH:D005355 Fibrosis Dietary Fats 27.3518296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 27.3520067830
MESH:D005355 Fibrosis Tretinoin 27.3517994277
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.6518462866
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.2716417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.188708960
MESH:D005909 Glioblastoma Curcumin 7.1917596214
MESH:D005909 Glioblastoma Tretinoin 7.1917312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.007505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D006258 Head and Neck Neoplasms Curcumin 7.7918829502 18462866
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.7916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1316084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.9620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.9611294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 10.9614991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.5120558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2911000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.476705139
MESH:D006529 Hepatomegaly pirinixic acid 8.1316221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.1315340226 12621046 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.0017701891
MESH:D006558 Herpes Genitalis Estradiol 5.0015709030
MESH:D019584 Hot Flashes Estradiol 3.7217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.028697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Tretinoin 3.1816870215
MESH:D006937 Hypercholesterolemia Curcumin 9.1018704882
MESH:D006937 Hypercholesterolemia Dietary Fats 9.1021332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5316778211
MESH:D006943 Hyperglycemia pirinixic acid 3.1420558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.5721332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9015034207
MESH:D006973 Hypertension Cyclosporine 4.8910903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8918670907 18850075
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.3615869954
MESH:D007248 Infertility, Male vinclozolin 3.0116467254
MESH:D007249 Inflammation Curcumin 15.6518403477 16956363 17151092
MESH:D007249 Inflammation Dietary Fats 15.6520412841
MESH:D007249 Inflammation polyphenols 15.6516366677
MESH:D007249 Inflammation Progesterone 15.6515869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 15.6512878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.1918596194 18200517
MESH:D007333 Insulin Resistance Dietary Fats 12.1211836018 18457598
MESH:D007333 Insulin Resistance Estradiol 12.1216393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 12.1216306350
MESH:D007410 Intestinal Diseases Tretinoin 3.7317994277
MESH:D007414 Intestinal Neoplasms Curcumin 4.1810783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.999022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.8016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.8015992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4115604871
MESH:D007674 Kidney Diseases Cyclosporine 5.8518776723 8314463 10903974
MESH:D007674 Kidney Diseases Estradiol 5.8515618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 17.4416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 17.446582329
MESH:D007680 Kidney Neoplasms Cyclosporine 17.4412371664
MESH:D007680 Kidney Neoplasms Estradiol 17.4415610895
MESH:D007889 Leiomyoma Curcumin 4.5318555241
MESH:D007938 Leukemia Curcumin 6.4218462866
MESH:D007938 Leukemia Tretinoin 6.4217143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.1616106398
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6616932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0719850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1219029980 17649720 19225113 16788101 16140955 17294898 16935935 16823087 17217047 17361223 12679006 19035177 17506722 17712046 17301526 19075265 16331271 19642359 15748426 16891316 17368321 17339181 16766008 9834237 17107899
MESH:D015458 Leukemia, T-Cell Curcumin 4.7216106398
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7016417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.279224671
MESH:D008103 Liver Cirrhosis Dietary Fats 2.8518296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1715034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 6.6718705752 18006644 17355460
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.6714659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.6715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.6712878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.6716248980 18397230
MESH:D008107 Liver Diseases Curcumin 4.4816956363
MESH:D008107 Liver Diseases polyphenols 4.4816698588
MESH:D008113 Liver Neoplasms Aflatoxin B1 10.539163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.5321137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 10.5320007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.5316984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.64598648 1399818 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 9.648603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.6412151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.8114755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.8120464547 17053015 18816296 20869020 18569708 20135361 18520028 20064080 6695378
MESH:D008175 Lung Neoplasms Curcumin 4.8118462866 19359593 16243823
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8119555203 11884234
MESH:D008223 Lymphoma Curcumin 3.5518462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.6516173963
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.9616891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 5.9617203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.4519453300
MESH:D008527 Medulloblastoma Tretinoin 2.7717453147
MESH:D008545 Melanoma Curcumin 3.4618462866 17885582
MESH:D008545 Melanoma Tretinoin 3.4616752155
MESH:D008569 Memory Disorders Curcumin 4.1117263510
MESH:D008591 Meningomyelocele Tretinoin 4.3916940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1516381670
MESH:D009101 Multiple Myeloma Curcumin 3.4819372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.8817962980
MESH:D009135 Muscular Diseases pirinixic acid 3.4716239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0517596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.1316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.1316411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.8218551238
MESH:D009361 Neoplasm Invasiveness Curcumin 4.3318495463
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.453581430
MESH:D009369 Neoplasms Benzo(a)pyrene 8.0611141357
MESH:D009369 Neoplasms pirinixic acid 8.0617405874
MESH:D009369 Neoplasms Tretinoin 8.0616594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.5012497104
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7017289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2419348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 16.1011399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 16.1014600291
MESH:D009421 Nervous System Malformations Tretinoin 16.109125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.6018462866
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.136679447
MESH:D009436 Neural Tube Defects Tretinoin 7.139142499
MESH:D009765 Obesity Curcumin 7.3719297423
MESH:D009765 Obesity Dietary Fats 7.3718674790 20132043 19632207 11836018 16723640 20518802 18457598 21332399 17217161
MESH:D009765 Obesity pirinixic acid 7.3720558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 14.9312819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 14.934026338 6482804
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 14.9314694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.993988306
MESH:D010024 Osteoporosis Curcumin 3.4418719352
MESH:D010051 Ovarian Neoplasms Curcumin 11.2118462866 19020741
MESH:D010051 Ovarian Neoplasms Estradiol 11.2119401270
MESH:D010051 Ovarian Neoplasms Progesterone 11.2117393432 16525653
MESH:D010051 Ovarian Neoplasms Tretinoin 11.2116936753
MESH:D010146 Pain Tretinoin 2.8716870215
MESH:D010190 Pancreatic Neoplasms Curcumin 5.3917440100 19196508 19401701
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.3915976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.447296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.446228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1812371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.3711896295 11222880 11399792 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.3718042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.9018220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8420887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5917292933
MESH:D011471 Prostatic Neoplasms Curcumin 2.5911398177 10851300 12497104 18226269 18769126 15129424 18156803
MESH:D011471 Prostatic Neoplasms Estradiol 2.5916740699
MESH:D011472 Prostatitis vinclozolin 4.9018629315
MESH:D011507 Proteinuria Tretinoin 3.5616636307
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D011625 Pterygium Tretinoin 4.7616723453
MESH:D011656 Pulmonary Emphysema Curcumin 4.4919168576
MESH:D015427 Reperfusion Injury pirinixic acid 2.3619058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.9818379247 10666014
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.343692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0616283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8418045962
MESH:D012509 Sarcoma Curcumin 4.0818462866
MESH:D012640 Seizures 2,4-dinitrotoluene 2.5018551238
MESH:D018805 Sepsis Curcumin 4.0418389075
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.2710029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.2716192470
MESH:D012878 Skin Neoplasms Tretinoin 9.2716467112
MESH:D013119 Spinal Cord Injuries Progesterone 4.2416503802 15862959
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.342093021 20155912
MESH:D013274 Stomach Neoplasms Tretinoin 2.3417261132
MESH:D013276 Stomach Ulcer Curcumin 3.4616631530 19188055
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.2217997062
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.021399818 6582329 6587162 7505956 3712494
MESH:D013964 Thyroid Neoplasms Tretinoin 7.0217045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.6619048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.7516051514
MESH:D014376 Tuberculosis Tretinoin 3.2016040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.7916049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.798074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.7917053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 11.7918593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.2318462866
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.2810091137
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6416129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.5816752155
MESH:D014605 Uveitis Cyclosporine 3.961336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D014820 Vitiligo Tretinoin 4.0216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
MESH:D015430 Weight Gain Dietary Fats 3.7016723640
MESH:D009396 Wilms Tumor Tretinoin 3.9316287080
MESH:D014985 Xerophthalmia Cyclosporine 4.4117120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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