AutismKB 2.0

Annotation Detail for CUL2


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Basic Information Top
Gene Symbol:CUL2 ( MGC131970 )
Gene Full Name: cullin 2
Band: 10p11.21
Quick LinksEntrez ID:8453; OMIM: 603135; Uniprot ID:CUL2_HUMAN; ENSEMBL ID: ENSG00000108094; HGNC ID: 2552
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04120Ubiquitin mediated proteolysis
hsa05211Renal cell carcinoma
hsa05200Pathways in cancer
No data
Pathway IDPathway Name
200122Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CUL2 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of CUL2 mRNAaffects expression 21346803
C006632 arsenic trioxide arsenic trioxide results in increased expression of CUL2 mRNAincreases expression 20458559
D019833 Genistein Genistein results in increased expression of CUL2 mRNAincreases expression 15256057
D012402 Rotenone Rotenone results in decreased expression of CUL2 mRNAdecreases expression 19013527
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CUL2 mRNAincreases expression 19684285
D014501 Uranium Uranium affects the expression of CUL2 mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of CUL2 mRNAaffects expression 15672453
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 9.637525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.6314514962 15322242 11752688
MESH:D000230 Adenocarcinoma arsenic trioxide 4.7011798837 19825857
MESH:D000230 Adenocarcinoma Genistein 4.7011473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.7816206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.7812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms Genistein 2.0516541309 17200150 16873071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0520435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5911589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.8216705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.8216217749 15073043 14691202 15553829 11135700
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.8216924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.2519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3512490120
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Genistein 3.4616332659
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.7614694615
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.936135515
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1912621046 15668235 15340226 8697196 16354765
MESH:D003110 Colonic Neoplasms Genistein 2.3217182828
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.9115095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.9117141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5310525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5310048152 20055451 15322242
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3218551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3615213294
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.4916647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4917107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.6118551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 6.6121346803
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.6120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2816714409 15322242 18230668
MESH:D004714 Endometrial Hyperplasia Genistein 4.9316402032
MESH:D016889 Endometrial Neoplasms Genistein 3.5111473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.259294722 10568697
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3612903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver arsenic trioxide 3.5315073043
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2520067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5416904648
MESH:D005909 Glioblastoma Genistein 3.4016598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4411294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2015340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.428697196 18606429 15340226 16354765 16959395
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9612200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.1816705839
MESH:D007938 Leukemia arsenic trioxide 6.7915070760
MESH:D007938 Leukemia Genistein 6.7917468513 18980019
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0412560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.6416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1716467208 20471514 19850784 16968895 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3616112521 16330433 19075265 19225113 16823087 15213294 9834237 16891316 17107899 17649720 19035177 12018890 11468182 11161223 16331271 16966277 15748426 17869043 17712046 15622746 19642359 17217047 12712474 12679006 15336539
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6316882451
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.4617823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.4612878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.867678174
MESH:D008113 Liver Neoplasms arsenic trioxide 7.8614682389
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.8616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.632876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.6320377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.6312151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5315213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.3519825857 11798837
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3511884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.0812929590 14578162
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2711468182 14977855 19549372 15949261 19417148
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.0518349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2616105982 16882451
MESH:D009203 Myocardial Infarction Genistein 2.9417141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.8417141266
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.2018551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2416624393
MESH:D009410 Nerve Degeneration Rotenone 4.0618619942 15790535 17356569
MESH:D009421 Nervous System Malformations Genistein 10.5616427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.5614600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2610525206
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.9016049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 9.9014694615
MESH:D010024 Osteoporosis Genistein 3.3919401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.3516169203
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.1819769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms Genistein 5.1819005980
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5915580305
MESH:D010235 Paraganglioma arsenic trioxide 4.4219927285
MESH:D010300 Parkinson Disease Rotenone 3.0519114014 18619942 15451049 19232380 16140633 11535288 18191903 11445065 16412576
MESH:D020734 Parkinsonian Disorders Rotenone 4.3015927086 18197244 15574749 15795934
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311896295 11118676 11222880 11399792
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.3019131511
MESH:D011471 Prostatic Neoplasms Genistein 3.3016925846 15378649 15256057
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2416646077
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6918551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2719014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3015213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.3516049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.3512845720 11780464 12973940 20435036
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6610091137
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
Pathway ID Pathway Name
KEGG:05200 Pathways in cancer
KEGG:05211 Renal cell carcinoma
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27048
    • No data
    Releated disease ID Related disease Name
    PA444101Esophageal Neoplasms
    PA443815Crohn Disease
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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