AutismKB 2.0

Annotation Detail for ACSS1


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Basic Information Top
Gene Symbol:ACSS1 ( ACAS2L,AceCS2L,FLJ45659,MGC33843 )
Gene Full Name: acyl-CoA synthetase short-chain family member 1
Band: 20p11.21
Quick LinksEntrez ID:84532; OMIM: NA; Uniprot ID:ACS2L_HUMAN; ENSEMBL ID: ENSG00000154930; HGNC ID: 16091
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY66-161oxidative ethanol degradation III (microsomal)
PWY66-21ethanol degradation II (cytosol)
PWY66-162ethanol degradation IV (peroxisomal)
PWY0-1313acetate conversion to acetyl-CoA
Pathway IDPathway Name
hsa00010Glycolysis / Gluconeogenesis
hsa00640Propanoate metabolism
hsa01100Metabolic pathways
hsa00620Pyruvate metabolism
Pathway IDPathway Name
Biological oxidations
Pathway IDPathway Name
200020Signaling events mediated by HDAC Class III
Pathway IDPathway Name
P02722Acetate utilization
Pathway IDPathway Name
500209Ethanol oxidation
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D004041 Dietary Fats Dietary Fats results in increased expression of ACSS1 mRNAincreases expression 18042831
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of ACSS1 mRNAincreases expression 15289156
D004958 Estradiol Estradiol results in increased expression of ACSS1 mRNAincreases expression 15289156
D019833 Genistein Genistein results in increased expression of ACSS1 mRNAincreases expression 15289156
D007657 Ketone Bodies Ketone Bodies results in increased expression of ACSS1 mRNAincreases expression 16807920
C041786 palm oil palm oil results in increased expression of ACSS1 mRNAincreases expression 18042831
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Estradiol 4.6811473722
MESH:D000230 Adenocarcinoma Genistein 4.6811473722
MESH:D000686 Amyloidosis Diethylstilbestrol 4.8615469931
MESH:D001161 Arteriosclerosis Dietary Fats 4.3115238619
MESH:D001943 Breast Neoplasms Dietary Fats 2.0220435547
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.0217129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 2.0217289903 12948864 17261762 16675129 19861407 17018787 14630087 18497071
MESH:D001943 Breast Neoplasms Genistein 2.0216541309 16873071 17200150
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.9316111702
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 4.9015948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.9016924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.9016924424
MESH:D002318 Cardiovascular Diseases Genistein 3.5116332659
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9818566989
MESH:D003110 Colonic Neoplasms Genistein 2.3317182828
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.9412952375 16002989
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5416647724
MESH:D003928 Diabetic Nephropathies Estradiol 3.7019279558
MESH:D050171 Dyslipidemias Dietary Fats 3.6718367378
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 13.4816402032
MESH:D004714 Endometrial Hyperplasia Genistein 13.4816402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 13.6615700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 13.6611473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 13.6611473722
MESH:D005234 Fatty Liver Dietary Fats 3.5618296743 19004024 17967931 19551842
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.8316534752 16513791 16611131 15751030 16002989
MESH:D005355 Fibrosis Dietary Fats 3.9418296743
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.4116452187
MESH:D005909 Glioblastoma Genistein 3.4516598420
MESH:D006558 Herpes Genitalis Estradiol 5.5515709030
MESH:D019584 Hot Flashes Estradiol 4.2717088409
MESH:D006937 Hypercholesterolemia Dietary Fats 3.9221332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.9721332399
MESH:D006965 Hyperplasia Diethylstilbestrol 4.8512960047 14722030
MESH:D007021 Hypospadias Diethylstilbestrol 5.0016002989
MESH:D007246 Infertility Diethylstilbestrol 4.7415036965
MESH:D007249 Inflammation Dietary Fats 2.5720412841
MESH:D007333 Insulin Resistance Dietary Fats 8.0218457598 11836018
MESH:D007333 Insulin Resistance Estradiol 8.0216393666 16627594
MESH:D007674 Kidney Diseases Estradiol 2.7415618244
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 8.4514681315 15003126 16762066
MESH:D007680 Kidney Neoplasms Estradiol 8.4515610895
MESH:D007859 Learning Disorders Diethylstilbestrol 4.4817184923
MESH:D007938 Leukemia Genistein 3.1618980019 17468513
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0318296743
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.6414659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.6417823541
MESH:D008113 Liver Neoplasms Diethylstilbestrol 2.7316712894 15890375
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.6115166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.6915700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 6.0416002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.7217203775 16891317 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.7214578162 12929590
MESH:D020149 Manganese Poisoning Estradiol 5.0019453300
MESH:D009203 Myocardial Infarction Genistein 2.9617141266
MESH:D015428 Myocardial Reperfusion Injury Estradiol 9.3316810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 9.3317141266
MESH:D009369 Neoplasms Diethylstilbestrol 2.8915313581
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1917289903
MESH:D009421 Nervous System Malformations Diethylstilbestrol 18.8311399458
MESH:D009421 Nervous System Malformations Estradiol 18.8316427766 11399458
MESH:D009421 Nervous System Malformations Genistein 18.8316427766
MESH:D009765 Obesity Dietary Fats 2.3420132043 21332399 17217161 18674790 11836018 19632207 18457598 20518802 16723640
MESH:D010024 Osteoporosis Genistein 3.4319401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.4416169203
MESH:D010051 Ovarian Neoplasms Estradiol 5.1719401270
MESH:D010051 Ovarian Neoplasms Genistein 5.1719005980
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.6914722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 5.0915687265 16977796
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 4.5717184923
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.2120887781
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.5715846301 17136230 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 2.5716740699
MESH:D011471 Prostatic Neoplasms Genistein 2.5716925846 15256057 15378649
MESH:D013088 Spermatocele Diethylstilbestrol 5.2316002989 16709447
MESH:D013978 Tibial Fractures Estradiol 5.2119048282
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 2.8716712894 17306315 16452187
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.3416175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.6914652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.4515809267 16690809
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.8516002989 16513791
MESH:D015430 Weight Gain Dietary Fats 4.0216723640
Pathway ID Pathway Name
REACT:13433 Biological oxidations
KEGG:00010 Glycolysis / Gluconeogenesis
KEGG:01100 Metabolic pathways
KEGG:00640 Propanoate metabolism
KEGG:00620 Pyruvate metabolism
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00131 - Adenosine monophosphate Dietary supplement;Micronutrient
DB00171 - Adenosine triphosphate Dietary supplement;Micronutrient
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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