AutismKB 2.0

Annotation Detail for CUL1


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Basic Information Top
Gene Symbol:CUL1 ( MGC149834,MGC149835 )
Gene Full Name: cullin 1
Band: 7q36.1
Quick LinksEntrez ID:8454; OMIM: 603134; Uniprot ID:CUL1_HUMAN; ENSEMBL ID: ENSG00000055130; HGNC ID: 2551
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04710Circadian rhythm - mammal
hsa04141Protein processing in endoplasmic reticulum
hsa04310Wnt signaling pathway
hsa04120Ubiquitin mediated proteolysis
hsa04350TGF-beta signaling pathway
hsa04110Cell cycle
hsa04114Oocyte meiosis
Pathway IDPathway Name
Signaling by Wnt
Cell Cycle, Mitotic
Signaling in Immune system
Pathway IDPathway Name
200064Canonical Wnt signaling pathway
200106Regulation of Wnt-mediated beta catenin signaling and target gene transcription
Pathway IDPathway Name
P00049Parkinson disease
Pathway IDPathway Name
500393SCF-beta-TrCP mediated degradation of Emi1
500310Degradation of beta-catenin by the destruction complex
500490Interleukin-1 signaling
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of CUL1 mRNAaffects expression 17562736
D006710 Homocysteine Homocysteine results in decreased expression of CUL1 mRNAdecreases expression 17326132
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CUL1 mRNAdecreases expression 19150397
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of CUL1 mRNAaffects cotreatment|increases expression 17183730
C097613 imatinib [tetraarsenic tetrasulfide co-treated with imatinib] results in increased expression of CUL1 mRNAaffects cotreatment|increases expression 19208803
C008493 methylselenic acid methylselenic acid results in increased expression of CUL1 mRNAincreases expression 18548127
C534735 tetraarsenic tetrasulfide [tetraarsenic tetrasulfide co-treated with imatinib] results in increased expression of CUL1 mRNAaffects cotreatment|increases expression 19208803
C534735 tetraarsenic tetrasulfide tetraarsenic tetrasulfide results in increased expression of CUL1 mRNAincreases expression 19208803
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of CUL1 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.828875741
MESH:D000015 Abnormalities, Multiple imatinib 11.3418322153
MESH:D000015 Abnormalities, Multiple Valproic Acid 11.3419490988
MESH:D000022 Abortion, Spontaneous imatinib 6.5918322153
MESH:D000550 Amblyopia Valproic Acid 5.6117688650
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.7617497229
MESH:D001321 Autistic Disorder Acetaminophen 2.2818445737
MESH:D001321 Autistic Disorder Homocysteine 2.2816297937 20468076
MESH:D001321 Autistic Disorder Valproic Acid 2.2818316065 15238991 18985861 20603192 18558336 18775368 17688650 18177632 17507914 16609825 17157402 18396377 19460635 19232924 18940202
MESH:D001714 Bipolar Disorder Valproic Acid 3.1820046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.548888407
MESH:D001859 Bone Neoplasms imatinib 5.5815867366
MESH:D001943 Breast Neoplasms imatinib 3.6517614352
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.393084413
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8820889678
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7820734317
MESH:D003324 Coronary Artery Disease Homocysteine 3.8216379339
MESH:D019465 Craniofacial Abnormalities imatinib 3.2618322153
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.2616575769 17688650 8888407
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9917906064 16177239 12153990 19739265 10915739 19416960 10663392 19085960 18713872 11461765 19164858 16781746 15619225 11287661 2444490 12392966 19923254 11834606 10774834 16393943 11743745 12958197 11739529 18071297 19420014 14986274 12540782 19370779 14550746 16081117 12594235 17562736 11529661 16485898 17522070 12705907 11421492 16109766 14725611 15968718 16227642
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 3.9919641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004421 Dystonia Valproic Acid 4.311851702
MESH:D004487 Edema imatinib 4.5819703484
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.463659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.2916628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0418234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.807562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.607750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.403659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1220426865
MESH:D017889 Exfoliation Syndrome Homocysteine 6.0416504073
MESH:D005234 Fatty Liver Valproic Acid 3.5419224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.2616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.4118558336 8888407
MESH:D018222 Fibromatosis, Aggressive imatinib 5.9817453242
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005901 Glaucoma Homocysteine 5.5516504073
MESH:D006330 Heart Defects, Congenital Homocysteine 4.1219638421
MESH:D006849 Hydrocephalus Valproic Acid 5.2017688650
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D020138 Hyperhomocysteinemia Homocysteine 4.9217369066 18234410 17292331
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.9316612254
MESH:D007674 Kidney Diseases Acetaminophen 2.3212587719 15629191
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive imatinib 10.0515748426 15107311 17301526 19208803
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive tetraarsenic tetrasulfide 10.0519208803
MESH:D007951 Leukemia, Myeloid imatinib 5.3417236224
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1817596541 16294345
MESH:D008106 Liver Cirrhosis, Experimental imatinib 3.2116596278
MESH:D008107 Liver Diseases Acetaminophen 1.6716611625 11587558 12587719 19784758 19014921 16610002 12969438 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.6417228818
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008591 Meningomyelocele Homocysteine 5.8416602021
MESH:D008881 Migraine Disorders Valproic Acid 3.3618765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.278888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2817596541
MESH:D009203 Myocardial Infarction Homocysteine 3.8017412321
MESH:D009362 Neoplasm Metastasis imatinib 4.0915867366
MESH:D009376 Neoplasms, Hormone-Dependent imatinib 5.8417614352
MESH:D009436 Neural Tube Defects Valproic Acid 3.2716359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D010014 Osteolysis imatinib 6.0715867366
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010300 Parkinson Disease Homocysteine 3.6416275827
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma imatinib 4.6012476293
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.1720603192
MESH:D011471 Prostatic Neoplasms methylselenic acid 3.8516205645
MESH:D019310 Pseudolymphoma Valproic Acid 4.9212752131 11422049
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4419155313
MESH:D012559 Schizophrenia Homocysteine 4.0616641680
MESH:D012559 Schizophrenia Valproic Acid 4.0615737665 19110320
MESH:D012640 Seizures Valproic Acid 2.8911738929 17978042 3137016 14763951 11044598 15475178 1511512 16876388
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9212833885
MESH:D013274 Stomach Neoplasms imatinib 3.2015786421
MESH:D013964 Thyroid Neoplasms imatinib 4.6116940797
MESH:D014178 Translocation, Genetic Valproic Acid 5.6117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.863119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.958888407
MESH:D014581 Urticaria Acetaminophen 3.2410982225
Pathway ID Pathway Name
KEGG:04110 Cell cycle
REACT:152 Cell Cycle, Mitotic
REACT:24941 Circadian Clock
KEGG:04710 Circadian rhythm - mammal
KEGG:04114 Oocyte meiosis
KEGG:04141 Protein processing in endoplasmic reticulum
REACT:11045 Signaling by Wnt
REACT:6900 Signaling in Immune system
KEGG:04350 TGF-beta signaling pathway
KEGG:04120 Ubiquitin mediated proteolysis
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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