AutismKB 2.0

Annotation Detail for ATRN


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Basic Information Top
Gene Symbol:ATRN ( DPPT-L,KIAA0548,MGC126754,MGCA )
Gene Full Name: attractin
Band: 20p13
Quick LinksEntrez ID:8455; OMIM: 603130; Uniprot ID:ATRN_HUMAN; ENSEMBL ID: ENSG00000088812; HGNC ID: 885
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ATRN mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of ATRN mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of ATRN mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ATRN mRNAaffects expression 16483693
D001194 Asbestos Asbestos affects the expression of ATRN mRNAaffects expression 17297452
C030123 coumarin coumarin results in decreased expression of ATRN mRNAdecreases expression 18480146
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of ATRN mRNAdecreases expression 19638242
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of ATRN mRNAdecreases expression 15576828
C006253 pirinixic acid pirinixic acid results in increased expression of ATRN mRNAincreases expression 18301758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.043712494
MESH:D000236 Adenoma Diethylnitrosamine 7.0410737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.0616434500 19052882 18056438 19061943 17162532 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.0616434500
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D050197 Atherosclerosis Asbestos 4.3318795166
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.341440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2117474063
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7816705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.783581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.783084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.7816698587 18210153 16288022 16878318 16779866 16569478 19519916 19052882 16830150 20727157 11831363 3084413 16807293 20214788 19822196 16935385 19539802 17761372 20007298 18788625 19394651 16328049 19701751 16502159 18506893 20514400 17138121 18393292 16540662 20432363 21159647 19383236 17428255 19107877 19171122 18971187 18785209 18691550 3581430 18978308 17978847 16681979 20935162 17055752 19335982 19208518 20524982 18494052 20084675 10672840 17173139 18056438 19919837 18665156 20512989 17162532 10737359 20101231 19418558
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.767296757
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.157505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.1517174075 7505956 21159647 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8719052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 14.269022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 14.2617110522 16105132 11677210 15861022 17333356 16919318 17681005
MESH:D002779 Cholestasis pirinixic acid 14.2619176532
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2718551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0612868966 8970840 18759878 11298694 2524372 11906362 8156756 14531868
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.713621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 4.9319647726
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.9320387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.4118551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.411440618 11289319 16192314 18692083 9328219 18648102 7440962 9022650 18289764 6679447 6482804 8291058 9653073
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.4119370779 11421492 10774834 15968718 14550746 16177239 12540782 12594235 12153990 19923254 11529661 14986274 16393943 19085960 11739529 12958197 12392966 17522070 11743745 15619225 16485898 19739265 17562736 11834606 10663392 16109766 12705907 19164858 19416960 19420014 11461765 16081117 16781746 17906064 18713872 2444490 14725611 16227642 18071297 11287661 10915739
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.4119107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4212538720
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4416302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005234 Fatty Liver Diethylnitrosamine 14.2821071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.2815345470
MESH:D005234 Fatty Liver pirinixic acid 14.2820131406 19236843
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.756705139
MESH:D006529 Hepatomegaly pirinixic acid 3.2516221962 19176532 18467677 19772884
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Diethylnitrosamine 2.4718785209
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.348074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 2.3015629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.9416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.946582329
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9318522880 19638242 18407596 20032147 18665156
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3115034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 4.0512587719 19784758 11587558 16611625 16610002 12969438 19460945 19014921
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0517034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4316871587 17185352
MESH:D008113 Liver Neoplasms Diethylnitrosamine 4.6618754104 19427195 18644402 19996281 19294768 20405173 19812893 20137499 20452335 19638242 18977376 19426721 2422723 21278145 20434301 12112319 21071580 19256749 18648771 21047994 19551842 19690152 20118626 16942905 15175105 20583210 19254457 19255062 20501860 19499222 18978307 19833225 19642983 20492335 20101389 2862719 15885732 19073162 19850985 10737359 19090486 9163691 21167192 12771043
MESH:D008113 Liver Neoplasms pirinixic acid 4.6620007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.321399818 3712494 6587162 598648
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.3219009564 2563599 19539802 16842330 18775883 9362446 16267830 17174075 18544905 21159647 18079962 17854601 18282651 18308698 18253720 19004024 19519916 3124819 17942915 19126423 18164116 18093689
MESH:D008175 Lung Neoplasms Asbestos 3.0212111688
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.0220970405 20512841 21163286 6695378
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008654 Mesothelioma Asbestos 4.1518310086 18709470 16564556 16919927 16319530
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.1418551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.943581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.943581430 9029167
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.046679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.7618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.7620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4420387270
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.5312819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.534026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4816540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.732563599
MESH:D011537 Pruritus Ethinyl Estradiol 3.6015861022 16919318
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6618551238
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2616709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.641399818 6582329 3712494 7505956 6587162
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.647505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2416049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.248074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6010091137
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D014689 Venous Insufficiency coumarin 6.0912708602
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7515869587 14671159
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25178
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450379mercaptopurine
    PA450428methotrexate
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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