AutismKB 2.0

Annotation Detail for TTF2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:TTF2 ( HuF2 )
Gene Full Name: transcription termination factor, RNA polymerase II
Band: 1p13.1
Quick LinksEntrez ID:8458; OMIM: 604718; Uniprot ID:TTF2_HUMAN; ENSEMBL ID: ENSG00000116830; HGNC ID: 12398
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
thyroid agenesis
hypothyroidism
DEVELOPMENTAL
cleft palate, isolated
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TTF2 mRNAaffects expression 21346803
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of TTF2 proteinaffects expression 20106945
D016572 Cyclosporine Cyclosporine results in increased expression of TTF2 mRNAincreases expression 20106945
D004317 Doxorubicin TTF2 protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D008727 Methotrexate TTF2 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TTF2 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TTF2 mRNAaffects binding|increases activity|increases expression 19710929
D011374 Progesterone Progesterone results in increased expression of TTF2 mRNAincreases expression 18070364
D014747 Vinblastine TTF2 protein affects the susceptibility to Vinblastineaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 4.5812039119
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Doxorubicin 2.6117418594
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D000419 Albuminuria Doxorubicin 4.8321441931
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.1417286800
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.0814601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.7117868700
MESH:D001930 Brain Injuries Progesterone 4.5615665606 15380490 15845082
MESH:D001932 Brain Neoplasms Doxorubicin 4.0417150277
MESH:D001943 Breast Neoplasms Doxorubicin 2.1015668708 17426702 18628466 15567936 19526202 16322301 16096432 15692762 16826403 11325840 16595493 15136595 18234424 16935488 15939500 17369602 16264153 15993339 16115903 18695136 18382427 15634643 15994142 17983394
MESH:D001943 Breast Neoplasms Methotrexate 2.1016978400
MESH:D001943 Breast Neoplasms Progesterone 2.1017614352 15562024 16175315
MESH:D002276 Carcinoid Tumor Doxorubicin 5.1916051944
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.8316705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.8312619106 12907637 21507988
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 4.8318059187 16234567 16023760 17876044
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 7.281485588 16201981
MESH:D002292 Carcinoma, Renal Cell Vinblastine 7.281485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.696189445
MESH:D009202 Cardiomyopathies Doxorubicin 3.6815811867 17131338 15792986 16364871 16952015 16455267 17928571 16109756 16278810 15505089 17351982 16731534 17382496 17308081 16651473 15476868 18627295 16612575 17974986 17519947 17924179 16269455 17329180 17007740 16242529
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0116243910 17334414
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6812371664
MESH:D002779 Cholestasis Cyclosporine 8.3519486331
MESH:D002779 Cholestasis pirinixic acid 8.3519176532
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.9818802399 18259882
MESH:D015179 Colorectal Neoplasms Vinblastine 2.9818802399
MESH:D019465 Craniofacial Abnormalities Methotrexate 2.669562676 12039119
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.3218551238
MESH:D003550 Cystic Fibrosis Methotrexate 4.4719747007
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003882 Dermatomyositis Methotrexate 5.4120191521
MESH:D003929 Diabetic Neuropathies Progesterone 4.8017187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 4.2321346803 18551238
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 4.2317416283
MESH:D004362 Drug Toxicity Doxorubicin 3.8418602426
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.0617692515
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.6017359293
MESH:D004715 Endometriosis Progesterone 3.9916134523
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.5318037988
MESH:D005234 Fatty Liver Cyclosporine 8.3819224547
MESH:D005234 Fatty Liver pirinixic acid 8.3820131406 19236843
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.9319069698
MESH:D005355 Fibrosis Cyclosporine 3.4512639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D005909 Glioblastoma Doxorubicin 3.4917150277
MESH:D006086 Graft vs Host Disease Methotrexate 5.4516518429
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.6815692506
MESH:D006331 Heart Diseases Doxorubicin 3.6412587719 16495754 17888722 16244372 16244371 16330681 17875725 14766674 16879835 18006777 18674790 16707910 16144979
MESH:D006333 Heart Failure Doxorubicin 7.5117481944
MESH:D006333 Heart Failure pirinixic acid 7.5120558911
MESH:D006394 Hemangiosarcoma Doxorubicin 4.1415692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006529 Hepatomegaly pirinixic acid 3.3018467677 19176532 16221962 19772884
MESH:D006689 Hodgkin Disease Doxorubicin 8.5215147373 18501091 17606976
MESH:D006689 Hodgkin Disease Vinblastine 8.5218180244 18501091
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.7115869954
MESH:D007249 Inflammation Progesterone 2.7015869954
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cyclosporine 6.538314463 10903974 18776723
MESH:D007674 Kidney Diseases Doxorubicin 6.5316775033 15369732 15699352
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.4016707910
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.9516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.9512371664
MESH:D007805 Language Development Disorders Methotrexate 5.369562676
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.5316085563
MESH:D008103 Liver Cirrhosis Methotrexate 3.8214986274
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.5316439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5315474484
MESH:D008113 Liver Neoplasms Aflatoxin B1 4.7418177683 2125692 9163691 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 4.7416377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.618603461
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 6.6117085340 16842330
MESH:D017563 Lung Diseases, Interstitial Methotrexate 5.4018516814
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.6914755239
MESH:D008175 Lung Neoplasms Doxorubicin 2.6917418594 6189445
MESH:D008223 Lymphoma Doxorubicin 8.4816098063
MESH:D008223 Lymphoma Methotrexate 8.4817352296
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.9917654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.8715621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.7215458769
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.7217203775 11408345
MESH:D008545 Melanoma Doxorubicin 3.9016827129
MESH:D008545 Melanoma Vinblastine 3.9015577323 12374674 18176117 17761969 16809738 18505091 15577320 16432458 16248763 18332650
MESH:D008654 Mesothelioma Doxorubicin 3.1417638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.7415792986
MESH:D052016 Mucositis Doxorubicin 13.6717415656
MESH:D052016 Mucositis Methotrexate 13.6717488658
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction Doxorubicin 6.0015857846 19429709
MESH:D009203 Myocardial Infarction pirinixic acid 6.0019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.2018551238
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0318259882
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009401 Nephrosis Doxorubicin 5.0816899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 10.0218481113 19348381
MESH:D009404 Nephrotic Syndrome Doxorubicin 10.0215640375 16889571
MESH:D009447 Neuroblastoma Doxorubicin 3.3715555623
MESH:D009503 Neutropenia Vinblastine 4.8317378895
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6616049721 12819281
MESH:D012516 Osteosarcoma Doxorubicin 4.3115930896
MESH:D010051 Ovarian Neoplasms Progesterone 2.5816525653 17393432
MESH:D003557 Phyllodes Tumor Doxorubicin 5.5317983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.5317638057
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.5118437689 15749863 16729912 16868541 15897917 16888761
MESH:D011565 Psoriasis Cyclosporine 6.1416882103
MESH:D011565 Psoriasis Methotrexate 6.1417410198
MESH:D051437 Renal Insufficiency Doxorubicin 11.5317922066
MESH:D051437 Renal Insufficiency Methotrexate 11.5317352296
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9218045962
MESH:D012509 Sarcoma Doxorubicin 4.2217203757 15625365 17710206 15675481 18313854 16767912
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.5216326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.1317846226
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6818551238
MESH:D012878 Skin Neoplasms Doxorubicin 3.0515692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.8717203757 15625365 16767912
MESH:D013119 Spinal Cord Injuries Progesterone 4.6216503802 15862959
MESH:D013576 Syndactyly Methotrexate 5.329562676
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.5516010429 17909728
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.4516049721
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.4517653716
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6510091137
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D014625 Vaginal Neoplasms Vinblastine 5.3515577323
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.5317638931 16364871 17334414 17678736
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved