AutismKB 2.0

Annotation Detail for TUBB6


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Basic Information Top
Gene Symbol:TUBB6 ( HsT1601,MGC132410,MGC4083,TUBB-5 )
Gene Full Name: tubulin, beta 6
Band: 18p11.21
Quick LinksEntrez ID:84617; OMIM: NA; Uniprot ID:TBB6_HUMAN; ENSEMBL ID: ENSG00000176014; HGNC ID: 20776
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04145Phagosome
hsa04540Gap junction
hsa05130Pathogenic Escherichia coli infection
Pathway IDPathway Name
Metabolism of proteins
No data
Pathway IDPathway Name
P00029Huntington disease
P00016Cytoskeletal regulation by Rho GTPase
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TUBB6 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of TUBB6 mRNAincreases expression 20406850
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of TUBB6 mRNAaffects expression 21346803
C035208 2-amino-4,6-dinitrotoluene 2-amino-4,6-dinitrotoluene affects the expression of TUBB6 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of TUBB6 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of TUBB6 proteinaffects expression 20106945
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TUBB6 mRNAaffects cotreatment|increases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of TUBB6 mRNAincreases expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of TUBB6 mRNAdecreases expression 20504355
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TUBB6 mRNAdecreases expression 20382639
C006780 bisphenol A bisphenol A results in increased expression of TUBB6 mRNAincreases expression 16474171
D016572 Cyclosporine Cyclosporine results in increased expression of TUBB6 mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of TUBB6 mRNAdecreases expression 18042831
D004041 Dietary Fats Dietary Fats results in increased expression of TUBB6 mRNAincreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TUBB6 mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of TUBB6 mRNAincreases expression 19638242
D004958 Estradiol Estradiol results in increased expression of TUBB6 mRNAincreases expression 16474171
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TUBB6 mRNAincreases expression 17942748
D019833 Genistein Genistein results in increased expression of TUBB6 mRNAincreases expression 16474171
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of TUBB6 mRNAaffects cotreatment|increases expression 17183730
C041786 palm oil palm oil results in decreased expression of TUBB6 mRNAdecreases expression 18042831
C041786 palm oil palm oil results in increased expression of TUBB6 mRNAincreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of TUBB6 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of TUBB6 mRNAincreases expression 19482888
D010656 Phenylephrine Phenylephrine results in increased expression of TUBB6 mRNAincreases expression 18158353
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TUBB6 mRNAaffects binding|decreases expression|increases activity 19710929
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of TUBB6 mRNAincreases expression 16474171
C066340 tolcapone tolcapone binds to TUBB6 proteinaffects binding 19783845
D019772 Topotecan TUBB6 protein affects the susceptibility to Topotecanaffects response to substance 16217747
D014303 Trinitrotoluene Trinitrotoluene affects the expression of TUBB6 mRNAaffects expression 21346803
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of TUBB6 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 2-amino-4,6-dinitrotoluene 18.887525203
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 18.886195326
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 18.887525203
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 18.888875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.7519490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7517505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.7520127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 9.7511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.7514692618
MESH:D000230 Adenocarcinoma Genistein 9.7511473722
MESH:D000236 Adenoma Benzo(a)pyrene 10.576695378
MESH:D000236 Adenoma beta-Naphthoflavone 10.5719389873
MESH:D000236 Adenoma Diethylnitrosamine 10.5710737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.2419061943 16434500 18056438 19052882 17620307 17162532
MESH:D018248 Adenoma, Liver Cell Phenobarbital 16.2417620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.2416434500
MESH:D017109 Akathisia, Drug-Induced tolcapone 6.1011080934
MESH:D000544 Alzheimer Disease tolcapone 3.2420150427
MESH:D000550 Amblyopia Valproic Acid 5.0417688650
MESH:D000799 Angioedema Acetaminophen 3.6510982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.4217497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8819183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.9517460149
MESH:D001161 Arteriosclerosis Dietary Fats 9.2815238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.2811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5515885639
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8520603192 17507914 19232924 18940202 19460635 17688650 18985861 18177632 18558336 18316065 15238991 17157402 18396377 16609825 18775368
MESH:D001714 Bipolar Disorder Valproic Acid 2.9817594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 2.9719483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.288888407
MESH:D001862 Bone Resorption bisphenol A 3.6911985600
MESH:D001919 Bradycardia Phenylephrine 4.3515306635
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.8720146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 2.8717123778
MESH:D001943 Breast Neoplasms Dietary Fats 2.8720435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.8717474063
MESH:D001943 Breast Neoplasms Estradiol 2.8717261762 12948864 18497071 16675129 17289903 14630087 19861407 17018787
MESH:D001943 Breast Neoplasms Genistein 2.8717200150 16541309 16873071
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2716111702
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 16.3816705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 16.3816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 16.383084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 16.3812907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 16.3816698587 16779866 16328049 3084413 18665156 19701751 18971187 19052882 20727157 16935385 20512989 20935162 18978308 17055752 18056438 3581430 17162532 16878318 10737359 16569478 19107877 19335982 16540662 20432363 16681979 18210153 16830150 21159647 18691550 19394651 20514400 20084675 19418558 18506893 19383236 20007298 16502159 17428255 20101231 20214788 19171122 18785209 19519916 17138121 17761372 10672840 19539802 17978847 20524982 18393292 17173139 16288022 19919837 19822196 19208518 16807293 18494052 11831363 18788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 16.3816924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 16.3816924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 16.3820007298 1701930 6705139 17173139 20935162
MESH:D002278 Carcinoma in Situ bisphenol A 4.8017123778
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0020419170
MESH:D006332 Cardiomegaly Phenylephrine 3.4311179087 17287366 17124262 16170337 15728586 11754973
MESH:D002318 Cardiovascular Diseases Genistein 3.1716332659
MESH:D002386 Cataract Acetaminophen 7.1410977129
MESH:D002386 Cataract Trinitrotoluene 7.1414694615 15817613
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 19.706135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 19.7020889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 19.7012371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 19.702727394 17174075 7505956 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 19.7018566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.064080065
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6420734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.5219052882
MESH:D002779 Cholestasis Cyclosporine 12.5319486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.5316919318 17110522 16105132 15861022 11677210 17333356 17681005
MESH:D002779 Cholestasis pirinixic acid 12.5319176532
MESH:D003110 Colonic Neoplasms Genistein 2.2617182828
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 2.7215531428
MESH:D000013 Congenital Abnormalities 2-amino-4,6-dinitrotoluene 9.5215095906
MESH:D000013 Congenital Abnormalities Trinitrotoluene 9.5215095906
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.898888407 16575769 17688650
MESH:D003490 Cyanosis 2,4-dinitrotoluene 17.7118551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 17.7118551238
MESH:D003490 Cyanosis Trinitrotoluene 17.7118551238
MESH:D003704 Dementia Polychlorinated Biphenyls 4.5316140633
MESH:D003866 Depressive Disorder tolcapone 4.177768276 11224284
MESH:D003865 Depressive Disorder, Major tolcapone 4.7410440460
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3418249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3620387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.3616647724
MESH:D003928 Diabetic Nephropathies Estradiol 3.2519279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 21.2518551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 21.2518551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2-amino-4,6-dinitrotoluene 21.2521346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 21.2517562736 12540782 16393943 14725611 10774834 11743745 12392966 16781746 19923254 18071297 16485898 10915739 2444490 19416960 19085960 17906064 15619225 11739529 19370779 11529661 12153990 19739265 12594235 11287661 15968718 14550746 16109766 12705907 16177239 11461765 11834606 19164858 18713872 11421492 16081117 14986274 19420014 10663392 12958197 17522070 16227642
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 21.2519107877
MESH:D056486 Drug-Induced Liver Injury tolcapone 21.2519783845 16604736
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 21.2518551238 21346803
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 21.251733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9119426721
MESH:D004409 Dyskinesia, Drug-Induced tolcapone 5.2111455177
MESH:D050171 Dyslipidemias Dietary Fats 3.3218367378
MESH:D004421 Dystonia Phenobarbital 9.841851702
MESH:D004421 Dystonia Valproic Acid 9.841851702
MESH:D004487 Edema pirinixic acid 2.3112083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.0112538720
MESH:D004714 Endometrial Hyperplasia Genistein 4.4016402032
MESH:D016889 Endometrial Neoplasms Estradiol 7.1019148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Genistein 7.1011473722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 10.163659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 10.1617275665 3659116
MESH:D004828 Epilepsies, Partial Phenobarbital 9.3311558140 3922381
MESH:D004828 Epilepsies, Partial Valproic Acid 9.333922381 16628512
MESH:D004827 Epilepsy Phenobarbital 6.3420417680
MESH:D004827 Epilepsy Valproic Acid 6.3418234410 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 8.336401628
MESH:D004832 Epilepsy, Absence Valproic Acid 8.337562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 10.677750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 10.677750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 9.843659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 9.843659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9216302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.1820426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.1816530937
MESH:D054908 Extensively Drug-Resistant Tuberculosis tolcapone 5.7519578428
MESH:D005234 Fatty Liver Cyclosporine 28.4619224547
MESH:D005234 Fatty Liver Dietary Fats 28.4619004024 17967931 19551842 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 28.4621071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 28.4615345470
MESH:D005234 Fatty Liver pirinixic acid 28.4620131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 28.4614986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 4.6916575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.958888407 18558336
MESH:D005355 Fibrosis Cyclosporine 8.0712639820 12168785
MESH:D005355 Fibrosis Dietary Fats 8.0718296743
MESH:D005756 Gastritis Acetaminophen 3.4816983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.038708960
MESH:D005909 Glioblastoma Genistein 3.1416598420
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.5620471113
MESH:D006333 Heart Failure pirinixic acid 2.4220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2315720958
MESH:D006529 Hepatomegaly Phenobarbital 13.4716109766
MESH:D006529 Hepatomegaly pirinixic acid 13.4719176532 19772884 18467677 16221962
MESH:D006529 Hepatomegaly Trinitrotoluene 13.4715817613
MESH:D006558 Herpes Genitalis Estradiol 4.8415709030
MESH:D019584 Hot Flashes Estradiol 3.5617088409
MESH:D006849 Hydrocephalus Valproic Acid 4.6717688650
MESH:D006930 Hyperalgesia Acetaminophen 2.5516870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4221332399
MESH:D006943 Hyperglycemia pirinixic acid 3.0220558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.4421332399
MESH:D006973 Hypertension Cyclosporine 5.1310903974
MESH:D006973 Hypertension Phenylephrine 5.1312717712 8949925
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.4416612254
MESH:D006984 Hypertrophy Phenylephrine 4.3818502941 12791704
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.4817937319
MESH:D007248 Infertility, Male Trinitrotoluene 6.4812150543
MESH:D007249 Inflammation Dietary Fats 4.7820412841
MESH:D007249 Inflammation Diethylnitrosamine 4.7818785209
MESH:D007333 Insulin Resistance bisphenol A 16.6216393666
MESH:D007333 Insulin Resistance Dietary Fats 16.6211836018 18457598
MESH:D007333 Insulin Resistance Estradiol 16.6216627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 16.6216306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2515604871
MESH:D007674 Kidney Diseases Acetaminophen 9.3415629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 9.3418776723 8314463 10903974
MESH:D007674 Kidney Diseases Estradiol 9.3415618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 16.4616705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 16.4616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 16.4612371664
MESH:D007680 Kidney Neoplasms Estradiol 16.4615610895
MESH:D007938 Leukemia Genistein 2.9317468513 18980019
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1216294345 17596541
MESH:D008103 Liver Cirrhosis Dietary Fats 10.4218296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.4220032147 18407596 19638242 18665156 18522880
MESH:D008103 Liver Cirrhosis Phenobarbital 10.4221047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.3614716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.3617823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.3615474484
MESH:D008107 Liver Diseases Acetaminophen 6.1919784758 16611625 19014921 12587719 19460945 12969438 16610002 11587558
MESH:D008107 Liver Diseases Diethylnitrosamine 6.1917034775
MESH:D008107 Liver Diseases Phenobarbital 6.1919363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0717185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 20.797678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 20.799163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 20.7921137059 20195826
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 20.7919389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 20.7919812893 15885732 19499222 19642983 19254457 2422723 19833225 18978307 15175105 2862719 19638242 19850985 19256749 19255062 18644402 19551842 9163691 20583210 18754104 20118626 10737359 20501860 18648771 21071580 21278145 19294768 19690152 20434301 19427195 19996281 21047994 21167192 19073162 19090486 20405173 20492335 12112319 18977376 16942905 20101389 12771043 19426721 20137499 20452335
MESH:D008113 Liver Neoplasms Phenobarbital 20.798742319 19812893 21047994 15975961 19482888 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 20.7920007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 21.852876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 21.858603461
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 21.8518164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 21.8517174075 16267830 18308698 18775883 17854601 19539802 2563599 18164116 21159647 17942915 19519916 18093689 9362446 19009564 16842330 18253720 19004024 18544905 18282651 18079962 3124819 19126423
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 21.851399818 6150874 17172636 18308698 2563599
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 21.851423854
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.0717228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.3114755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.3118816296 20064080 18569708 6695378 20869020 17053015 20135361 18520028 20464547
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.3121163286 20970405 6695378 20512841
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.6811408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 5.6812929590 14578162
MESH:D020149 Manganese Poisoning Estradiol 4.2919453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5916801185
MESH:D008881 Migraine Disorders Valproic Acid 3.0618803445 18765137
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0416381670
MESH:D009135 Muscular Diseases pirinixic acid 3.3216239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.858888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.0517596541
MESH:D009203 Myocardial Infarction Genistein 5.4117141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.4119151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.3316810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 13.3317141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.3316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2817484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 16.6718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 16.6718551238 7678174
MESH:D009336 Necrosis Trinitrotoluene 16.6718551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.493581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 4.5111141357
MESH:D009369 Neoplasms pirinixic acid 4.5117405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5417289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1219348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 15.4011399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 15.4011399458 16427766
MESH:D009421 Nervous System Malformations Genistein 15.4016427766
MESH:D009436 Neural Tube Defects Valproic Acid 3.0116359493 8888407
MESH:D009447 Neuroblastoma Topotecan 3.7515176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.6618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.6620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9220387270
MESH:D009765 Obesity Dietary Fats 4.2718457598 17217161 16723640 18674790 20518802 19632207 11836018 21332399 20132043
MESH:D009765 Obesity pirinixic acid 4.2720558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 14.2216049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 14.2216049721
MESH:D009784 Occupational Diseases Trinitrotoluene 14.2212819281 17852074 14694615
MESH:D010018 Osteomalacia Phenobarbital 4.1717016548
MESH:D010024 Osteoporosis Genistein 3.1419401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.9116169203
MESH:D010049 Ovarian Diseases bisphenol A 4.8011985600
MESH:D010051 Ovarian Neoplasms Estradiol 4.7019401270
MESH:D010051 Ovarian Neoplasms Genistein 4.7019005980
MESH:D010146 Pain Acetaminophen 2.2416870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.0316540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.0316965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5111578682
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 5.7816702228
MESH:D010300 Parkinson Disease tolcapone 5.787566641 20334432 20216409 18328768 11586115 8635184 8739811 1977408 19783845 19578428 9333106 16758261 11793426 9305320 10651109 11746615 17089403 9708959 9754991 11432539 9591521
MESH:D011230 Precancerous Conditions Cyclosporine 14.3412371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.342563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.342563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.1010548101
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.1020603192
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.9820887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.9820887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8917292933
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8916740699
MESH:D011471 Prostatic Neoplasms Estradiol 1.8916740699
MESH:D011471 Prostatic Neoplasms Genistein 1.8915256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 1.8915721890
MESH:D011537 Pruritus Ethinyl Estradiol 3.1216919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 11.5512752131
MESH:D019310 Pseudolymphoma Valproic Acid 11.5512752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011629 Puberty, Precocious bisphenol A 4.5910548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.0019155313
MESH:D012559 Schizophrenia Valproic Acid 2.0415737665 19110320
MESH:D012640 Seizures 2,4-dinitrotoluene 17.2218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 17.2218551238
MESH:D012640 Seizures Phenobarbital 17.223137016 11442880 4039156 16876388
MESH:D012640 Seizures Trinitrotoluene 17.2218551238
MESH:D012640 Seizures Valproic Acid 17.2217978042 11044598 15475178 1511512 11738929 3137016 16876388 14763951
MESH:D003294 Seizures, Febrile Phenobarbital 4.636407741
MESH:D012852 Sinusitis Phenylephrine 4.517327846
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.2810029692 19755658
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7516709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.6319490988
MESH:D013163 Splenomegaly Trinitrotoluene 5.0115817613
MESH:D013226 Status Epilepticus Valproic Acid 4.3512833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.2820155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.2818456281
MESH:D019966 Substance-Related Disorders bisphenol A 3.7916045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9915669648
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.707505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.701399818
MESH:D013978 Tibial Fractures Estradiol 4.4919048282
MESH:D014178 Translocation, Genetic Valproic Acid 5.0417262798
MESH:D018088 Tuberculosis, Multidrug-Resistant tolcapone 5.7519578428
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.333119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 7.8316049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 7.8316049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.8317053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.458888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.3510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.3510091137
MESH:D014581 Urticaria Acetaminophen 2.8010982225
MESH:D014591 Uterine Diseases bisphenol A 4.8214652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1214692618
MESH:D014605 Uveitis Cyclosporine 3.791336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3714671159 15869587
MESH:D014820 Vitiligo tolcapone 5.0110573327
MESH:D015430 Weight Gain Dietary Fats 3.5816723640
MESH:D014985 Xerophthalmia Cyclosporine 4.2517120751
Pathway ID Pathway Name
REACT:18266 Axon guidance
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
KEGG:04540 Gap junction
REACT:604 Hemostasis
REACT:11123 Membrane Trafficking
REACT:17015 Metabolism of proteins
KEGG:05130 Pathogenic Escherichia coli infection
KEGG:04145 Phagosome
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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