AutismKB 2.0

Annotation Detail for SUPT3H


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Basic Information Top
Gene Symbol:SUPT3H ( SPT3,SPT3L )
Gene Full Name: suppressor of Ty 3 homolog (S. cerevisiae)
Band: 6p21.1
Quick LinksEntrez ID:8464; OMIM: 602947; Uniprot ID:SUPT3_HUMAN; ENSEMBL ID: ENSG00000196284; HGNC ID: 11466
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
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No data
Pathway IDPathway Name
200093C-MYC pathway
No data
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Related Diseases/Disorders Top
No data
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Desease Name
height
CHEMDEPENDENCY
ADHD
PSYCH
attention-deficit hyperactivity disorder
smoking cessation
DEVELOPMENTAL
Desease Name
Height
Attention deficit hyperactivity disorder
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SUPT3H proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SUPT3H mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SUPT3H mRNAdecreases expression 20382639
D003024 Clozapine Clozapine results in increased expression of SUPT3H mRNAincreases expression 16715494
D016572 Cyclosporine Cyclosporine results in increased expression of SUPT3H mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of SUPT3H mRNAdecreases expression 18042831
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SUPT3H mRNAaffects cotreatment|increases expression 17942748
D006220 Haloperidol Haloperidol results in increased expression of SUPT3H mRNAincreases expression 16715494
C041786 palm oil palm oil results in decreased expression of SUPT3H mRNAdecreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SUPT3H mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of SUPT3H mRNAincreases expression 18301758
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SUPT3H mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SUPT3H mRNAincreases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0414514962 11752688 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2820464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2814692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.736695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.5616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.5616835633
MESH:D000380 Agranulocytosis Clozapine 5.2314617031 16160616 12649775
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001161 Arteriosclerosis Dietary Fats 10.5015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.5011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001321 Autistic Disorder Haloperidol 2.7319368416 18080171
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.2419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.2412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8017474063 20146248
MESH:D001943 Breast Neoplasms Dietary Fats 1.8020435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8020435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 1.9712907637 12619106 21507988
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4416120746 18670907 18850075
MESH:D002375 Catalepsy Haloperidol 5.101977408 15215559
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.8720889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8712371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Cyclosporine 13.9519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.9516105132 15861022 17681005 17110522 11677210 17333356 16919318
MESH:D002779 Cholestasis pirinixic acid 13.9519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.158697196 12621046 16354765 15340226 15668235
MESH:D003072 Cognition Disorders Clozapine 5.1417123785
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 15322242 10048152
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.9920210726
MESH:D003704 Dementia Haloperidol 4.7211575062
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.6116402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.6117107852
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.7715331141
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D050171 Dyslipidemias Clozapine 9.2016402076
MESH:D050171 Dyslipidemias Dietary Fats 9.2018367378
MESH:D004487 Edema pirinixic acid 7.0012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.0011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1218230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3512538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4620426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Cyclosporine 19.9419224547
MESH:D005234 Fatty Liver Dietary Fats 19.9419551842 19004024 17967931 18296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.9415345470
MESH:D005234 Fatty Liver pirinixic acid 19.9419236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Cyclosporine 15.7812639820 12168785
MESH:D005355 Fibrosis Dietary Fats 15.7818296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.7820067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6711294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly pirinixic acid 8.8516221962 19772884 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.8515340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2616959395 15340226 16354765 8697196 18606429
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7321332399
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006948 Hyperkinesis Clozapine 5.1016046005
MESH:D006949 Hyperlipidemias Dietary Fats 3.7621332399
MESH:D006973 Hypertension Cyclosporine 5.1010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1018670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007249 Inflammation Dietary Fats 5.1420412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1412200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 7.5411836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.5416306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.418314463 18776723 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8512371664
MESH:D008064 Lipidoses Clozapine 4.0617567588
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9518296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1712878042
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.072125692 15890375 18177683 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.0721137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 11.0720007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.0716984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.088603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.0812151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4414755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4420135361 18520028 20869020 17053015 20064080 18569708 6695378 18816296 20464547
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4419555203 11884234
MESH:D001523 Mental Disorders Clozapine 9.0216856516
MESH:D001523 Mental Disorders Haloperidol 9.0216856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.5319142101
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009369 Neoplasms Benzo(a)pyrene 5.0311141357
MESH:D009369 Neoplasms pirinixic acid 5.0317405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4118481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D009765 Obesity Clozapine 7.6518515891 19142110
MESH:D009765 Obesity Dietary Fats 7.6519632207 20518802 21332399 16723640 17217161 18674790 11836018 18457598 20132043
MESH:D009765 Obesity pirinixic acid 7.6520558911
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811222880 11399792 11118676 11896295
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9517292933
MESH:D011537 Pruritus Ethinyl Estradiol 3.5116919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D011595 Psychomotor Agitation Haloperidol 5.1311575062
MESH:D011618 Psychotic Disorders Clozapine 9.4915331141
MESH:D011618 Psychotic Disorders Haloperidol 9.4911575062
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012559 Schizophrenia Clozapine 4.1617123785 20452607 20521326 16141801 11151749 18855531 19369910 11763009 18806925 20168265 20521320 17726453 17667964 20107430 20580759
MESH:D012559 Schizophrenia Haloperidol 4.1620107430 1830565 18513383 19369910
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.6719755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.8720210726
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2217053015
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6815869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D015430 Weight Gain Clozapine 10.2416402076 16141801 20564506 17502770 20521320 20107430
MESH:D015430 Weight Gain Dietary Fats 10.2416723640
MESH:D015431 Weight Loss Clozapine 5.2717933447
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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