AutismKB 2.0

Annotation Detail for SORBS2


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Basic Information Top
Gene Symbol:SORBS2 ( ARGBP2,FLJ93447,KIAA0777,PRO0618 )
Gene Full Name: sorbin and SH3 domain containing 2
Band: 4q35.1
Quick LinksEntrez ID:8470; OMIM: NA; Uniprot ID:SRBS2_HUMAN; ENSEMBL ID: ENSG00000154556; HGNC ID: 24098
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of SORBS2 mRNAdecreases expression 19933214
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SORBS2 proteinaffects expression 20106945
D001194 Asbestos Asbestos affects the expression of SORBS2 mRNAaffects expression 17297452
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SORBS2 mRNAdecreases expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SORBS2 mRNAdecreases expression 20713471
C006780 bisphenol A bisphenol A affects the expression of SORBS2 mRNAaffects expression 20170705
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SORBS2 mRNAaffects expression 17484886
D002330 Carmustine Carmustine results in decreased expression of SORBS2 mRNAdecreases expression 15980968
D003345 Corticosterone Corticosterone results in increased expression of SORBS2 mRNAincreases expression 15755911
D016572 Cyclosporine Cyclosporine results in decreased expression of SORBS2 mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in decreased expression of SORBS2 mRNAdecreases expression 20106945
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of SORBS2 mRNAaffects cotreatment|increases expression 17404688
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SORBS2 mRNAaffects expression 20170705
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SORBS2 mRNAaffects expression 20170705
D005047 Etoposide SORBS2 protein affects the susceptibility to Etoposideaffects response to substance 16217747
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of SORBS2 mRNAaffects cotreatment|increases expression 17404688
D011374 Progesterone Progesterone results in increased expression of SORBS2 mRNAincreases expression 17404688
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SORBS2 mRNAdecreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9315322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.0820127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 7.0811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.0814692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.686695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1519183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6915885639
MESH:D050197 Atherosclerosis Asbestos 4.2518795166
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D019046 Bone Marrow Neoplasms Etoposide 5.2614601052
MESH:D001862 Bone Resorption bisphenol A 3.9211985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.4317868700
MESH:D001930 Brain Injuries Progesterone 4.3315665606 15380490 15845082
MESH:D001932 Brain Neoplasms Carmustine 4.4416187019
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9817474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 2.9817123778
MESH:D001943 Breast Neoplasms Estradiol 2.9812948864 17018787 16675129 17261762 14630087 18497071 19861407 17289903
MESH:D001943 Breast Neoplasms Etoposide 2.9816322251
MESH:D001943 Breast Neoplasms Progesterone 2.9817614352 16175315 15562024
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9820435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5516111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8515721981 16097048 15673190 16192424 3786805 18705752 10355542 16227642 16050911 15700767 16011737 16124888
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.6412619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.6418788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.6416924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.0717123778
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0620419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3918850075 16120746 18670907
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.7012371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.7018566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis Cyclosporine 7.9119486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.9117333356 16919318 17681005 11677210 16105132 17110522 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1215340226 8697196 12621046 15668235 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4619279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.5617187935
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.777179309 11566570 2869522 4309450 21278145 15998439 10915739 16177239 7440962 10092053 16227642 6623471 9327722 6884620 17522070 15027814 15968718 7120509 3786805 3732212 19336974 19085960
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0015322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.2512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 9.2517692515
MESH:D016889 Endometrial Neoplasms Estradiol 3.0111473722 19148513 18566989
MESH:D004715 Endometriosis Progesterone 9.1016134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.1010568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0216530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.3816045604 19224547 12631006 17595544 12795759 61145 16239168 15959796
MESH:D005234 Fatty Liver Cyclosporine 13.3819224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.3815345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005355 Fibrosis Carbon Tetrachloride 15.1518705752
MESH:D005355 Fibrosis Cyclosporine 15.1512168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.1520067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D005909 Glioblastoma Carmustine 3.9616187019
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.5420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5411294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6619110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9615340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.1315709030
MESH:D006561 Herpes Simplex Etoposide 4.6410809021
MESH:D006689 Hodgkin Disease Etoposide 3.9215147373 16200630 17606976 18180244 16135485
MESH:D019584 Hot Flashes Estradiol 3.8517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1416354765 18606429 16959395 15340226 8697196
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6116899240
MESH:D006973 Hypertension Cyclosporine 5.0110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0118850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1615338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8816569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.4715869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5217937319
MESH:D007249 Inflammation Progesterone 5.0715869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0712878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 7.5516393666
MESH:D007333 Insulin Resistance Estradiol 7.5516393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007674 Kidney Diseases Cyclosporine 6.048314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 6.0415618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.4212371664
MESH:D007680 Kidney Neoplasms Estradiol 7.4215610895
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8316943688 17334410 11903743 11408273 17174718 16239168 21278145 17157831 16221502
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.4614716496 14620537 15959796 15123356 12667390 12958196 12666154 17557913 11481614 17714472 15052691 15996030 18420326 18006644 18277467 18395914 18263696 18054572 20821823 12389079 18395095 18412020 18166357 15338365 18156304 17805973 18481824 12445418 15876570 18251166 17640975 17698563 18418968 18429990 17900296 18376398 16033810 17631135 17525996 18187930 14716833 15362042 15893842 15931870 16027843 18279442 17976157 18205269 12445421 18472094 18705752 13678700 15057751 14512876 16011737 18339082 14748882 15370692 16097048 15818738 17944888 16192424 12609069 16248980 16015684 16136751 18317297 15673190 17565644 12741479 15650968 12649538 16116963 17761835 18472332 12546737 14724832 17481882 17823541 12632512 15730626 17766677 10355542 17869086 12632514 12898905 17708605 17721639 16638106 17922224 15925388 12586293 18210741
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.4614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4612878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0915830285 16964402 17285989 16246199 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2415123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7416899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 10.8518177683 9163691 15890375 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.8521137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.8519294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.8516984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.008603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.0012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.0012151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.9414755239
MESH:D008175 Lung Neoplasms Asbestos 4.9412111688
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9418569708 17053015 18520028 20869020 20464547 20064080 18816296 20135361 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9419555203 11884234
MESH:D008223 Lymphoma Etoposide 3.9612556972 12854902
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 10.3112807724
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.3116891317 17203775 11807958 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 10.3117203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.5819453300
MESH:D008545 Melanoma Carmustine 2.8712393984
MESH:D008654 Mesothelioma Asbestos 4.1016319530 18310086 16564556 18709470 16919927
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2316381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3216810080
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1911141357
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8117289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3318481113 19348381
MESH:D009421 Nervous System Malformations bisphenol A 16.7516427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 16.7516427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 16.7514600291
MESH:D010049 Ovarian Diseases bisphenol A 5.0711985600
MESH:D010051 Ovarian Neoplasms Estradiol 4.9219401270
MESH:D010051 Ovarian Neoplasms Progesterone 4.9216525653 17393432
MESH:D010190 Pancreatic Neoplasms Etoposide 3.2919003803
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2712371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.7910548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.7911118676 11399792 11896295 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.7420887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.7420887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0917292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.0916740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.0916740699
MESH:D011471 Prostatic Neoplasms Etoposide 2.0917172428
MESH:D011537 Pruritus Ethinyl Estradiol 3.3916919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D011629 Puberty, Precocious bisphenol A 4.8710548101
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8718045962
MESH:D012512 Sarcoma, Ewing's Etoposide 4.7714601052
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5510029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0416709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.3616503802 15862959
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D019966 Substance-Related Disorders bisphenol A 4.0716045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013978 Tibial Fractures Estradiol 4.7819048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2017053015
MESH:D014591 Uterine Diseases bisphenol A 5.1114652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3614692618
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5914671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA142670890
    • No data
    No data
    Releated drug ID Related drug Name
    PA449014cisplatin
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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