AutismKB 2.0

Annotation Detail for IRS4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:IRS4 ( IRS-4,PY160 )
Gene Full Name: insulin receptor substrate 4
Band: Xq22.3
Quick LinksEntrez ID:8471; OMIM: 603510; Uniprot ID:IRS4_HUMAN; ENSEMBL ID: ENSG00000133124; HGNC ID: 6128
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04920Adipocytokine signaling pathway
hsa04910Insulin signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04960Aldosterone-regulated sodium reabsorption
hsa04930Type II diabetes mellitus
No data
No data
Pathway IDPathway Name
P00033Insulin/IGF pathway-protein kinase B signaling cascade
P00032Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of IRS4 mRNAaffects expression 17562736
D001149 Arsenates [Atrazine co-treated with Arsenates] results in increased expression of IRS4 mRNAaffects cotreatment|increases expression 18585445
D001280 Atrazine [Atrazine co-treated with Arsenates] results in increased expression of IRS4 mRNAaffects cotreatment|increases expression 18585445
D004052 Diethylnitrosamine Diethylnitrosamine affects the expression of IRS4 mRNAaffects expression 20387270
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of IRS4 mRNAincreases expression 20387270
D010634 Phenobarbital Phenobarbital affects the expression of IRS4 mRNAaffects expression 19136022
C006253 pirinixic acid NCF1 protein inhibits the reaction [pirinixic acid results in decreased expression of IRS4 mRNA]decreases expression|decreases reaction 17950772
C006253 pirinixic acid pirinixic acid affects the expression of IRS4 mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid results in decreased expression of IRS4 mRNAdecreases expression 17950772
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.906195326
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D000236 Adenoma Diethylnitrosamine 3.0110737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 20.2518056438 19052882 16434500 19061943 17162532 17620307
MESH:D018248 Adenoma, Liver Cell Phenobarbital 20.2517620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 20.2516434500
MESH:D000382 Agricultural Workers' Diseases Atrazine 4.6811874814
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2017474063
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.773084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.7720935162 20727157 3581430 18210153 18785209 16288022 19822196 16569478 20101231 16878318 16830150 19052882 20524982 17138121 19519916 19171122 18971187 3084413 17428255 19539802 19919837 21159647 18056438 19701751 16681979 16935385 18978308 20214788 18691550 17173139 16807293 20514400 10737359 16502159 20084675 17978847 19335982 18788625 20432363 18506893 19394651 16328049 18494052 17761372 19418558 18393292 20512989 17055752 16540662 19208518 16698587 10672840 11831363 19383236 16779866 19107877 17162532 20007298 18665156
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.7717173139 6705139 1701930 20007298 20935162
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.062727394 17174075 21159647 7505956
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.674080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9719052882
MESH:D002779 Cholestasis pirinixic acid 3.0519176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2520387270
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0011834606 15619225 11461765 17562736 19416960 10774834 17906064 14550746 11421492 19164858 19085960 12540782 12705907 19420014 11287661 19923254 16081117 11529661 10915739 12153990 19739265 2444490 14725611 16393943 16781746 11743745 12958197 12594235 16227642 11739529 16109766 12392966 18071297 16485898 14986274 19370779 15968718 10663392 16177239 18713872 17522070
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 4.0019107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004421 Dystonia Phenobarbital 4.361851702
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.533659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.393922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.836401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.677750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.483659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.6416302075
MESH:D005234 Fatty Liver Diethylnitrosamine 8.7820387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 8.7819236843 20131406
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006529 Hepatomegaly Phenobarbital 9.9016109766
MESH:D006529 Hepatomegaly pirinixic acid 9.9019176532 16221962 18467677 19772884
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D007248 Infertility, Male Atrazine 3.9112948887
MESH:D007249 Inflammation Diethylnitrosamine 2.5218785209
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3612587719 15629191
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 7.1620032147 18407596 18522880 19638242 18665156
MESH:D008103 Liver Cirrhosis Phenobarbital 7.1621047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 6.8816611625 11587558 12969438 19460945 16610002 19014921 12587719 19784758
MESH:D008107 Liver Diseases Diethylnitrosamine 6.8817034775
MESH:D008107 Liver Diseases Phenobarbital 6.8819363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms Diethylnitrosamine 8.0020137499 20434301 19426721 20492335 18754104 19256749 19690152 21047994 19638242 20118626 18644402 9163691 19294768 18978307 19812893 19642983 21278145 19427195 12112319 19551842 12771043 19090486 20452335 2862719 18977376 20583210 19499222 16942905 15175105 19073162 19254457 19996281 20101389 15885732 18648771 10737359 19255062 20405173 21071580 19833225 21167192 2422723 20501860 19850985
MESH:D008113 Liver Neoplasms Phenobarbital 8.0019812893 19073162 8742319 21047994 15975961 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 8.0020007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.5919539802 17854601 18775883 18093689 18544905 21159647 16267830 17942915 18079962 18282651 19009564 9362446 18253720 19126423 3124819 2563599 19004024 16842330 17174075 18164116 19519916 18308698
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.5918308698 1399818 6150874 17172636 2563599
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.766695378 21163286 20970405 20512841
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D008654 Mesothelioma Atrazine 3.631916698
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.9417484760
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.679029167 3581430
MESH:D009369 Neoplasms pirinixic acid 2.0817405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 9.0918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 9.0920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.6420387270
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D010018 Osteomalacia Phenobarbital 4.8317016548
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.5716540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.5716965848
MESH:D010300 Parkinson Disease Atrazine 3.3717218051
MESH:D011230 Precancerous Conditions Diethylnitrosamine 10.062563599
MESH:D011230 Precancerous Conditions Phenobarbital 10.062563599
MESH:D019310 Pseudolymphoma Phenobarbital 5.0212752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012135 Respiratory Sounds Atrazine 4.9311874814
MESH:D012640 Seizures Phenobarbital 2.893137016 4039156 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.286407741
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.997505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.991399818
MESH:D014581 Urticaria Acetaminophen 3.3310982225
Pathway ID Pathway Name
KEGG:04920 Adipocytokine signaling pathway
KEGG:04960 Aldosterone-regulated sodium reabsorption
KEGG:04910 Insulin signaling pathway
KEGG:04722 Neurotrophin signaling pathway
KEGG:04930 Type II diabetes mellitus
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29923
    • No data
    Releated disease ID Related disease Name
    PA443756Colonic Neoplasms
    PA443560Breast Neoplasms
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved