AutismKB 2.0

Annotation Detail for HDGFRP2


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Basic Information Top
Gene Symbol:HDGFRP2 ( HDGF2,MGC2641 )
Gene Full Name: -
Band: 19p13.3
Quick LinksEntrez ID:84717; OMIM: NA; Uniprot ID:HDGR2_HUMAN; ENSEMBL ID: ENSG00000167674; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of HDGFRP2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of HDGFRP2 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HDGFRP2 mRNAaffects expression 16483693
C014347 decitabine decitabine results in increased expression of HDGFRP2 mRNAincreases expression 15251184
C014347 decitabine [Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of HDGFRP2 mRNAaffects cotreatment|increases expression 15251184
C010176 halofuginone halofuginone results in increased expression of HDGFRP2 mRNAincreases expression 17180598
D010656 Phenylephrine Phenylephrine results in decreased expression of HDGFRP2 mRNAdecreases expression 18158353
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of HDGFRP2 mRNAaffects cotreatment|increases expression 15251184
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HDGFRP2 proteindecreases expression 16548065
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2414514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.3817460149
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001919 Bradycardia Phenylephrine 4.9415306635
MESH:D001943 Breast Neoplasms decitabine 2.0719208741 18320071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.0616705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.0616705839
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6519215824
MESH:D006332 Cardiomegaly Phenylephrine 7.3411179087 15728586 11754973 17124262 17287366 16170337
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.3418850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.956135515
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2015340226 8697196 12621046 15668235 16354765
MESH:D003110 Colonic Neoplasms decitabine 2.3717616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.1218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.1218551238
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.5718551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.5721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3516714409 15322242 18230668
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.5619294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.299294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.6619215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4610048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2515340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.498697196 18606429 15340226 16959395 16354765
MESH:D006965 Hyperplasia halofuginone 5.6011874485
MESH:D006973 Hypertension Phenylephrine 5.6012717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.6018670907 18850075
MESH:D006984 Hypertrophy Phenylephrine 4.8412791704 18502941
MESH:D007248 Infertility, Male decitabine 3.3817581917
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9812200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.1516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.1516705839
MESH:D007938 Leukemia decitabine 3.1919235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.2819117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4119387464 17679729 18206229 18460780 18704418 19010910
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.9118055864
MESH:D008103 Liver Cirrhosis halofuginone 4.1717180598
MESH:D008106 Liver Cirrhosis, Experimental halofuginone 2.8016489207 18458672 12175628 11172339 14739098
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.8012878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.667678174
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.272876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2712151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008223 Lymphoma decitabine 3.6119470736
MESH:D008545 Melanoma decitabine 2.2716505122 17785578
MESH:D009101 Multiple Myeloma decitabine 3.5418172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.5219157545 16882708 19010910 18608210
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.7018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.7018551238 7678174
MESH:D009369 Neoplasms decitabine 2.8319116145 17925555 19470736
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.7812819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.7816049721
MESH:D010051 Ovarian Neoplasms decitabine 2.7219331143 19259094
MESH:D010190 Pancreatic Neoplasms decitabine 2.8419294695
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911399792 11118676 11222880 11896295
MESH:D055728 Primary Myelofibrosis decitabine 5.0917616702
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.7119155313
MESH:D012640 Seizures 2,4-dinitrotoluene 6.4718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.4718551238
MESH:D012852 Sinusitis Phenylephrine 5.107327846
MESH:D012871 Skin Diseases halofuginone 3.5711874485
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1516192470
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013964 Thyroid Neoplasms decitabine 3.5417967635
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.8816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.8816049721
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.8819087683 17616700
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.3510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.3510091137
MESH:D014604 Uveal Neoplasms decitabine 5.3617785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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