AutismKB 2.0

Annotation Detail for CDC42BPA


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Basic Information Top
Gene Symbol:CDC42BPA ( DKFZp686L1738,DKFZp686P1738,FLJ23347,KIAA0451,MRCK,MRCKA,PK428 )
Gene Full Name: CDC42 binding protein kinase alpha (DMPK-like)
Band: 1q42.13
Quick LinksEntrez ID:8476; OMIM: 603412; Uniprot ID:MRCKA_HUMAN; ENSEMBL ID: ENSG00000143776; HGNC ID: 1737
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200057CDC42 signaling events
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D006710 Homocysteine Homocysteine results in decreased expression of CDC42BPA mRNAdecreases expression 17326132
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CDC42BPA mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of CDC42BPA mRNAincreases expression 19128835
15761015
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CDC42BPA mRNAaffects cotreatment|decreases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CDC42BPA mRNAaffects cotreatment|decreases expression 18164116
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of CDC42BPA mRNAaffects expression 17555576
C051890 irinotecan irinotecan analog results in decreased expression of CDC42BPA mRNAdecreases expression 18927307
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CDC42BPA mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of CDC42BPA mRNAincreases expression 18301758
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of CDC42BPA mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of CDC42BPA mRNAdecreases expression 19244175
C029297 vinylidene chloride vinylidene chloride results in increased expression of CDC42BPA proteinincreases expression 14565772
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of CDC42BPA mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of CDC42BPA mRNAdecreases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of CDC42BPA mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.3919825857 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3914692618
MESH:D000236 Adenoma beta-Naphthoflavone 7.1419389873
MESH:D000236 Adenoma Diethylnitrosamine 7.146695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.7516434500 19052882 19061943 17620307 17162532 18056438
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.7516434500
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001321 Autistic Disorder Homocysteine 3.0316297937 20468076
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.4716206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.4719483382
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2217474063
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4811589617
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1116050911
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.1214691202 15553829 11135700 16217749 15073043
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.1218665156 19519916 16935385 17138121 20432363 17761372 18056438 17428255 20214788 16288022 16502159 19394651 21159647 16807293 16540662 16779866 16328049 19171122 20101231 20935162 19822196 3581430 18494052 20084675 18978308 17978847 16569478 17173139 19418558 18785209 19107877 19335982 19383236 19919837 20727157 18788625 16830150 19052882 16681979 16878318 10737359 19539802 20512989 18393292 20524982 18506893 17162532 17055752 20007298 3084413 18971187 18210153 19208518 10672840 16698587 20514400 18691550 19701751 11831363
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2512490120
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.952727394 17174075 21159647 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8119052882
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0911677210 17110522 16105132 15861022 16919318 17333356 17681005
MESH:D002779 Cholestasis pirinixic acid 8.0919176532
MESH:D003092 Colitis Selenium 3.9517936198
MESH:D003110 Colonic Neoplasms irinotecan 2.6117725105 17287894
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.7120501625
MESH:D015179 Colorectal Neoplasms irinotecan 2.7117454858 15273666 16303861 18259882 18509181 16391804 17159606
MESH:D003324 Coronary Artery Disease Homocysteine 3.8016379339
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.7510525206
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.7519769572
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2415213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2220387270
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.7519107877
MESH:D056486 Drug-Induced Liver Injury Selenium 6.7515131321
MESH:D056486 Drug-Induced Liver Injury vinylidene chloride 6.753697828
MESH:C538011 Eales disease Vitamin E 4.929068938
MESH:D004487 Edema pirinixic acid 2.6212083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3512538720
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3316302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3412903497
MESH:D017889 Exfoliation Syndrome Homocysteine 5.8916504073
MESH:D005234 Fatty Liver arsenic trioxide 19.9615073043
MESH:D005234 Fatty Liver Diethylnitrosamine 19.9620387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.9615345470
MESH:D005234 Fatty Liver pirinixic acid 19.9620131406 19236843
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4216904648
MESH:D005901 Glaucoma Homocysteine 5.4416504073
MESH:D006330 Heart Defects, Congenital Homocysteine 7.4119638421
MESH:D006330 Heart Defects, Congenital Vitamin E 7.4116080930
MESH:D006333 Heart Failure pirinixic acid 7.2220558911
MESH:D006333 Heart Failure Selenium 7.2217162251
MESH:D006529 Hepatomegaly pirinixic acid 3.1718467677 16221962 19176532 19772884
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7416863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.1914716179
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D020138 Hyperhomocysteinemia Homocysteine 4.8318234410 17292331 17369066
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007249 Inflammation Diethylnitrosamine 2.4418785209
MESH:D007251 Influenza, Human Selenium 11.7016624496
MESH:D007251 Influenza, Human Vitamin E 11.7016624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7216306350
MESH:D007674 Kidney Diseases vinylidene chloride 7.097839370
MESH:D007674 Kidney Diseases Vitamin E 7.0912488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0216518626
MESH:D007938 Leukemia arsenic trioxide 2.8915070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9317077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1616467208 16968895 20471514 19850784 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3019075265 12018890 17107899 15748426 19225113 15622746 16891316 17869043 16823087 16331271 15213294 16966277 11161223 15336539 19642359 17217047 11468182 12679006 17649720 12712474 16112521 17712046 19035177 16330433 9834237
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5116882451
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8918522880 20032147 19638242 18665156 18407596
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4115474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4116169303
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1317034775
MESH:D008113 Liver Neoplasms arsenic trioxide 11.1314682389
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 11.1319389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.1319499222 21071580 18644402 19294768 18754104 18648771 19638242 20434301 19690152 18977376 21278145 21167192 19426721 16942905 10737359 20501860 19833225 18978307 19256749 19427195 20452335 19996281 12771043 19551842 20137499 20101389 20405173 2422723 20492335 20583210 9163691 15885732 21047994 19850985 19812893 19254457 12112319 19255062 19073162 19090486 2862719 15175105 20118626 19642983
MESH:D008113 Liver Neoplasms pirinixic acid 11.1320007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.4420377131
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.4418164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.4418079962 16267830 18544905 19539802 18775883 19009564 17942915 19519916 3124819 19004024 18093689 16842330 18282651 17174075 18308698 9362446 18164116 18253720 21159647 19126423 2563599 17854601
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4615213294
MESH:D008171 Lung Diseases Vitamin E 3.2716863852
MESH:D055370 Lung Injury vinylidene chloride 5.583697828
MESH:D008175 Lung Neoplasms arsenic trioxide 3.5511798837 19825857
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.5520512841 21163286 6695378 20970405
MESH:D008175 Lung Neoplasms Vitamin E 3.5511062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8515318939
MESH:D008591 Meningomyelocele Homocysteine 5.7116602021
MESH:D008654 Mesothelioma Selenium 2.8415107826
MESH:D052016 Mucositis irinotecan 5.2017159606
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2014977855 15949261 19417148 19549372 11468182
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2216882451 16105982
MESH:D009203 Myocardial Infarction Homocysteine 6.1717412321
MESH:D009203 Myocardial Infarction pirinixic acid 6.1719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1216624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 6.133581430 9029167
MESH:D009362 Neoplasm Metastasis irinotecan 6.1318259882
MESH:D009369 Neoplasms pirinixic acid 2.0117405874
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2010525206
MESH:D009447 Neuroblastoma irinotecan 3.548761367
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4620387270
MESH:D017599 Neuroectodermal Tumors irinotecan 4.928761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3320387270
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4412452020 19769630 16624393
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.4215580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4216540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010235 Paraganglioma arsenic trioxide 4.3119927285
MESH:D010300 Parkinson Disease Homocysteine 3.6216275827
MESH:D010954 Plasmacytoma Selenium 5.1115087411
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.682563599
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2719131511
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2715084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.5116919318 15861022
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1216646077
MESH:D012559 Schizophrenia Homocysteine 3.1216641680
MESH:D012871 Skin Diseases Vitamin E 2.4718709164
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.5117007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.5118456281
MESH:D013274 Stomach Neoplasms irinotecan 3.5115723263
MESH:D020521 Stroke Vitamin E 3.6316517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.5519014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.557505956
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1515213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5320435036 12973940 12845720 11780464
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6815869587 14671159
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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