AutismKB 2.0

Annotation Detail for PLCD4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PLCD4 ( MGC12837 )
Gene Full Name: phospholipase C, delta 4
Band: 2q35
Quick LinksEntrez ID:84812; OMIM: 605939; Uniprot ID:PLCD4_HUMAN; ENSEMBL ID: ENSG00000115556; HGNC ID: 9062
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6367D-myo-inositol-5-phosphate metabolism
LIPASYN-PWYphospholipases
PWY-6351D-myo-inositol (1,4,5)-trisphosphate biosynthesis
Pathway IDPathway Name
hsa00562Inositol phosphate metabolism
hsa04020Calcium signaling pathway
hsa01100Metabolic pathways
hsa04070Phosphatidylinositol signaling system
No data
No data
Pathway IDPathway Name
P04385Histamine H1 receptor mediated signaling pathway
P04391Oxytocin receptor mediated signaling pathway
P04394Thyrotropin-releasing hormone receptor signaling pathway
P043745HT2 type receptor mediated signaling pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of PLCD4 mRNAincreases expression 16788091
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of PLCD4 mRNAdecreases expression 18648102
D000872 Anthocyanins Anthocyanins results in increased expression of PLCD4 mRNAincreases expression 18803703
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PLCD4 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLCD4 mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in decreased expression of PLCD4 mRNAdecreases expression 18035473
D005503 Food Additives Food Additives results in increased expression of PLCD4 mRNAincreases expression 18803703
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of PLCD4 mRNAincreases expression 17616710
D010634 Phenobarbital Phenobarbital results in increased expression of PLCD4 mRNAincreases expression 12807726
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PLCD4 mRNAaffects binding|decreases expression|increases activity 19710929
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLCD4 mRNAaffects cotreatment|increases expression 17942748
C052342 topiramate topiramate results in decreased expression of PLCD4 mRNAdecreases expression 16979414
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.956195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.9515322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8414692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.833712494
MESH:D018248 Adenoma, Liver Cell Phenobarbital 18.4717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 18.4716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 18.4716835633
MESH:D000437 Alcoholism topiramate 5.1319331489 17925516 18552399
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.2411289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.2419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.2412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6920435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.073581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 3.071701930 20935162 20007298 17173139 6705139
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.737296757
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4416120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.857505956
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.434080065
MESH:D002659 Child Development Disorders, Pervasive topiramate 4.1415650499
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.989022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.9811677210 16105132 17110522 16919318 17333356 15861022 17681005
MESH:D002779 Cholestasis pirinixic acid 13.9819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1516354765 15668235 12621046 8697196 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9712868966 14531868 8156756 8970840 2524372 11906362 18759878 11298694
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.642952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.8717107852
MESH:D003924 Diabetes Mellitus, Type 2 topiramate 4.8716979414
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.8116192314 11289319 1440618 9653073 7440962 9328219 18289764 6679447 18692083 18648102 9022650 8291058 6482804
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004421 Dystonia Phenobarbital 4.151851702
MESH:D004487 Edema pirinixic acid 7.0012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.0011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1215322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3512538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1510568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.283659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.0911558140 3922381
MESH:D004827 Epilepsy Phenobarbital 7.4020417680
MESH:D004827 Epilepsy topiramate 7.4019148780
MESH:D004832 Epilepsy, Absence Phenobarbital 3.676401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.437750514
MESH:D004833 Epilepsy, Temporal Lobe topiramate 6.4916499746
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.213659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.753581430
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.7515547733 15150132 16704527 15623463 15264214 15547721 16510608 15878914 16805852
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.0115345470
MESH:D005234 Fatty Liver pirinixic acid 8.0120131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.246705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1220067830
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.197505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4011294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.676705139
MESH:D006529 Hepatomegaly Phenobarbital 15.4416109766
MESH:D006529 Hepatomegaly pirinixic acid 15.4416221962 19176532 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.4415340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.268697196 16959395 15340226 16354765 18606429
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1115034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007249 Inflammation Flavonoids 5.2217296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2212878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.7216306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.248074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.086582329
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9621047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1712878042
MESH:D008107 Liver Diseases Phenobarbital 2.2019363144
MESH:D008113 Liver Neoplasms Phenobarbital 7.638742319 19812893 21047994 19073162 15975961 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 7.6320007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6316984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.296587162 598648 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.292563599 1399818 17172636 6150874 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.2912151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008881 Migraine Disorders topiramate 4.6716942474 18803445 18759728 18765137
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.6717484760
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.523581430
MESH:D009369 Neoplasms pirinixic acid 2.0117405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.006679447
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.556482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.243988306
MESH:D010018 Osteomalacia Phenobarbital 4.5617016548
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5316965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.667296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.696228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.752563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811222880 11399792 11896295 11118676
MESH:D011537 Pruritus Ethinyl Estradiol 3.5116919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.7112752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.483692021
MESH:D012640 Seizures Phenobarbital 6.824039156 3137016 16876388 11442880
MESH:D012640 Seizures topiramate 6.8216499746
MESH:D003294 Seizures, Febrile Phenobarbital 5.026407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.3312958204 17575124
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.506587162 1399818 3712494 7505956 6582329
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.501399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.328074119
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:00562 Inositol phosphate metabolism
KEGG:01100 Metabolic pathways
KEGG:04070 Phosphatidylinositol signaling system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33390
    • No data
    Releated disease ID Related disease Name
    PA445062Neoplasms
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved