AutismKB 2.0

Annotation Detail for CILP


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Basic Information Top
Gene Symbol:CILP ( CILP-1,HsT18872 )
Gene Full Name: cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
Band: 15q22.31
Quick LinksEntrez ID:8483; OMIM: 603489; Uniprot ID:CILP1_HUMAN; ENSEMBL ID: ENSG00000138615; HGNC ID: 1980
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
Lumbar disc disease, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D002945 Cisplatin CILP protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004041 Dietary Fats Dietary Fats results in increased expression of CILP mRNAincreases expression 18042831
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of CILP mRNAincreases expression 19371625
D019833 Genistein Genistein results in increased expression of CILP mRNAincreases expression 19371625
C041786 palm oil palm oil results in increased expression of CILP mRNAincreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CILP mRNAaffects binding|increases activity|increases expression 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury Cisplatin 4.2815814532 17670903 12690470
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D000230 Adenocarcinoma Cisplatin 4.9217638652 11798837
MESH:D000230 Adenocarcinoma Genistein 4.9211473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D000686 Amyloidosis Diethylstilbestrol 4.8615469931
MESH:D001161 Arteriosclerosis Dietary Fats 4.3115238619
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.4114601052
MESH:D001943 Breast Neoplasms Cisplatin 2.0618382427 19526202
MESH:D001943 Breast Neoplasms Dietary Fats 2.0620435547
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.0617129689 15324884
MESH:D001943 Breast Neoplasms Genistein 2.0616873071 16541309 17200150
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 4.9917982673
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 4.9915948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.9916924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.1216685392 12023789
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 2.8917066447 6189445 18337622
MESH:D002318 Cardiovascular Diseases Genistein 3.5116332659
MESH:D002779 Cholestasis pirinixic acid 3.0519176532
MESH:D003110 Colonic Neoplasms Genistein 2.3317182828
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.9416002989 12952375
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5416647724
MESH:D004362 Drug Toxicity Cisplatin 4.0812649298 15033597 19839026 12231392
MESH:D050171 Dyslipidemias Dietary Fats 3.6718367378
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 13.4816402032
MESH:D004714 Endometrial Hyperplasia Genistein 13.4816402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 8.3315700306 16804899
MESH:D016889 Endometrial Neoplasms Genistein 8.3311473722
MESH:D004938 Esophageal Neoplasms Cisplatin 2.8416481741 17638652 15464296 16785472 15173087
MESH:D005234 Fatty Liver Dietary Fats 8.8018296743 19551842 17967931 19004024
MESH:D005234 Fatty Liver pirinixic acid 8.8019236843 20131406
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.8316611131 16002989 16534752 16513791 15751030
MESH:D005355 Fibrosis Dietary Fats 3.9418296743
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.4116452187
MESH:D005909 Glioblastoma Genistein 3.4516598420
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.9115102660 15464296
MESH:D034381 Hearing Loss Cisplatin 4.5819898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.6915464296
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006529 Hepatomegaly pirinixic acid 3.4119772884 18467677 19176532 16221962
MESH:D006689 Hodgkin Disease Cisplatin 3.8816170182 16200630
MESH:D006937 Hypercholesterolemia Dietary Fats 3.9221332399
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.9721332399
MESH:D006965 Hyperplasia Diethylstilbestrol 4.8512960047 14722030
MESH:D007021 Hypospadias Diethylstilbestrol 5.0016002989
MESH:D007246 Infertility Diethylstilbestrol 4.7415036965
MESH:D007249 Inflammation Dietary Fats 2.5720412841
MESH:D007333 Insulin Resistance Dietary Fats 7.8911836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.8916306350
MESH:C535531 Intervertebral disc disease marker/mechanism
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.6615464296
MESH:D007674 Kidney Diseases Cisplatin 3.4015190930 12649298 12231392 18289764 19839026
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 3.7315003126 16762066 14681315
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 5.3111231351
MESH:D007859 Learning Disorders Diethylstilbestrol 4.4817184923
MESH:D007938 Leukemia Genistein 3.1618980019 17468513
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0318296743
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.5117823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5115474484
MESH:D008113 Liver Neoplasms Diethylstilbestrol 4.9215890375 16712894
MESH:D008113 Liver Neoplasms pirinixic acid 4.9220007298 15890375 16377806
MESH:D008175 Lung Neoplasms Cisplatin 2.346189445 17225452 11798837
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.6115166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.6915700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 6.0416002989
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.1212929590 14578162
MESH:D008545 Melanoma Cisplatin 2.5017761969 12393984 16809738 11135225 18505091 18332650 16432458 12883367 16248763 15577323 12374674 18176117 17023156
MESH:D018328 Melanoma, Amelanotic Cisplatin 5.2415990972
MESH:D008654 Mesothelioma Cisplatin 3.3517638057
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction Genistein 6.0417141266
MESH:D009203 Myocardial Infarction pirinixic acid 6.0419151258
MESH:D015428 Myocardial Reperfusion Injury Genistein 9.2017141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 9.2016411023
MESH:D009369 Neoplasms Cisplatin 9.1516773208
MESH:D009369 Neoplasms Diethylstilbestrol 9.1515313581
MESH:D009369 Neoplasms pirinixic acid 9.1517405874
MESH:D009395 Nephritis, Interstitial Cisplatin 5.0115464296
MESH:D009421 Nervous System Malformations Diethylstilbestrol 11.2411399458
MESH:D009421 Nervous System Malformations Genistein 11.2416427766
MESH:D009447 Neuroblastoma Cisplatin 3.598761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 5.168761367
MESH:D009765 Obesity Dietary Fats 4.6419632207 20132043 18457598 11836018 20518802 17217161 16723640 21332399 18674790
MESH:D009765 Obesity pirinixic acid 4.6420558911
MESH:D010024 Osteoporosis Genistein 3.4319401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.4416169203
MESH:D010051 Ovarian Neoplasms Cisplatin 5.4117225452 19769630 6897625 15464296
MESH:D010051 Ovarian Neoplasms Genistein 5.4119005980
MESH:D010190 Pancreatic Neoplasms Cisplatin 3.0819003803
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.6915464296
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.6914722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 5.0915687265 16977796
MESH:D010997 Pleural Neoplasms Cisplatin 5.8617638057
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 4.5717184923
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.4015046698 15846301 17136230
MESH:D011471 Prostatic Neoplasms Genistein 3.4015256057 15378649 16925846
MESH:D051437 Renal Insufficiency Cisplatin 4.8215464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.8114601052
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.8615464296
MESH:D013088 Spermatocele Diethylstilbestrol 5.2316709447 16002989
MESH:D013274 Stomach Neoplasms Cisplatin 2.3317522103 18396642 15958060
MESH:D013736 Testicular Neoplasms Cisplatin 4.9817225452 15464296
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 5.7812973940 15464296 17225452
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 5.7816712894 17306315 16452187
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 10.7416803524
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 10.7416175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.6914652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.4515809267 16690809
MESH:D014625 Vaginal Neoplasms Cisplatin 12.5115577323
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 12.5116002989 16513791
MESH:D014839 Vomiting Cisplatin 5.2411897121
MESH:D015430 Weight Gain Dietary Fats 4.0216723640
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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