Annotation Detail for LRCH3
Basic Information
Top
| Gene Symbol: | LRCH3 ( FLJ20994,FLJ43245,FLJ44976,MGC4126 ) |
|---|
| Gene Full Name: | leucine-rich repeats and calponin homology (CH) domain containing 3 |
|---|
| Band: | 3q29 |
|---|
| Quick Links | Entrez ID:84859; OMIM: NA; Uniprot ID:LRCH3_HUMAN; ENSEMBL ID: ENSG00000186001; HGNC ID: 28637 |
|---|
| Relate to Another Database: |
SFARIGene;
denovo-db |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D001564 |
Benzo(a)pyrene |
Benzo(a)pyrene results in decreased expression of LRCH3 mRNA | decreases expression | 20106945
|
| C051890 |
irinotecan |
irinotecan analog results in decreased expression of LRCH3 mRNA | decreases expression | 18927307
|
| C006253 |
pirinixic acid |
[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of LRCH3 mRNA | affects binding|increases activity|increases expression | 19710929
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D055371 |
Acute Lung Injury |
|
pirinixic acid |
3.64 | 18653653 |
| MESH:D000230 |
Adenocarcinoma |
|
Benzo(a)pyrene |
2.06 | 20127859 20464547 |
| MESH:D000236 |
Adenoma |
|
Benzo(a)pyrene |
2.88 | 6695378 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
pirinixic acid |
4.22 | 16434500 |
| MESH:D017544 |
Aortic Aneurysm, Abdominal |
|
Benzo(a)pyrene |
4.73 | 19183758 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
pirinixic acid |
3.63 | 19483382 |
| MESH:D001943 |
Breast Neoplasms |
|
Benzo(a)pyrene |
1.99 | 17474063 20146248 |
| MESH:D002294 |
Carcinoma, Squamous Cell |
|
Benzo(a)pyrene |
2.14 | 20419170 |
| MESH:D002779 |
Cholestasis |
|
pirinixic acid |
3.15 | 19176532 |
| MESH:D003110 |
Colonic Neoplasms |
|
irinotecan |
2.65 | 17287894 17725105 |
| MESH:D015179 |
Colorectal Neoplasms |
|
irinotecan |
2.36 | 18259882 15273666 18509181 17159606 17454858 16391804 16303861 |
| MESH:D003876 |
Dermatitis, Atopic |
|
pirinixic acid |
2.59 | 18249437 |
| MESH:D004487 |
Edema |
|
pirinixic acid |
2.96 | 12083418 |
| MESH:D004938 |
Esophageal Neoplasms |
|
Benzo(a)pyrene |
2.09 | 16530937 |
| MESH:D005234 |
Fatty Liver |
|
pirinixic acid |
3.25 | 19236843 20131406 |
| MESH:D006330 |
Heart Defects, Congenital |
|
Benzo(a)pyrene |
2.85 | 20471113 |
| MESH:D006333 |
Heart Failure |
|
pirinixic acid |
2.78 | 20558911 |
| MESH:D006529 |
Hepatomegaly |
|
pirinixic acid |
3.64 | 16221962 18467677 19772884 19176532 |
| MESH:D006943 |
Hyperglycemia |
|
pirinixic acid |
3.63 | 20558911 |
| MESH:D007333 |
Insulin Resistance |
|
pirinixic acid |
2.90 | 16306350 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
pirinixic acid |
1.35 | 15474484 |
| MESH:D008113 |
Liver Neoplasms |
|
Benzo(a)pyrene |
4.81 | 20195826 21137059 |
| MESH:D008113 |
Liver Neoplasms |
|
pirinixic acid |
4.81 | 20007298 15890375 16377806 |
| MESH:D008175 |
Lung Neoplasms |
|
Benzo(a)pyrene |
1.57 | 6695378 20464547 20135361 18569708 20064080 18816296 18520028 17053015 20869020 |
| MESH:D009062 |
Mouth Neoplasms |
|
Benzo(a)pyrene |
3.53 | 16381670 |
| MESH:D052016 |
Mucositis |
|
irinotecan |
5.75 | 17159606 |
| MESH:D009135 |
Muscular Diseases |
|
pirinixic acid |
4.16 | 16239165 |
| MESH:D009203 |
Myocardial Infarction |
|
pirinixic acid |
2.29 | 19151258 |
| MESH:D015428 |
Myocardial Reperfusion Injury |
|
pirinixic acid |
3.29 | 16411023 |
| MESH:D009362 |
Neoplasm Metastasis |
|
irinotecan |
3.31 | 18259882 |
| MESH:D009369 |
Neoplasms |
|
Benzo(a)pyrene |
5.44 | 11141357 |
| MESH:D009369 |
Neoplasms |
|
pirinixic acid |
5.44 | 17405874 |
| MESH:D009447 |
Neuroblastoma |
|
irinotecan |
3.67 | 8761367 |
| MESH:D017599 |
Neuroectodermal Tumors |
|
irinotecan |
5.47 | 8761367 |
| MESH:D009765 |
Obesity |
|
pirinixic acid |
1.89 | 20558911 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Benzo(a)pyrene |
2.90 | 17292933 |
| MESH:D015427 |
Reperfusion Injury |
|
pirinixic acid |
2.56 | 19058328 |
| MESH:D012878 |
Skin Neoplasms |
|
Benzo(a)pyrene |
2.54 | 10029692 19755658 |
| MESH:D013274 |
Stomach Neoplasms |
|
Benzo(a)pyrene |
2.63 | 20155912 2093021 |
| MESH:D013274 |
Stomach Neoplasms |
|
irinotecan |
2.63 | 15723263 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
Benzo(a)pyrene |
2.31 | 17053015 |
Related Pathway Information