AutismKB 2.0

Annotation Detail for KLHL22


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Basic Information Top
Gene Symbol:KLHL22 ( KELCHL )
Gene Full Name: kelch-like 22 (Drosophila)
Band: 22q11.21
Quick LinksEntrez ID:84861; OMIM: NA; Uniprot ID:KLH22_HUMAN; ENSEMBL ID: ENSG00000099910; HGNC ID: 25888
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of KLHL22 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of KLHL22 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of KLHL22 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of KLHL22 mRNAaffects expression 17562736
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.963712494
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.741440618 11289319
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.9416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.9416705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.947296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.943084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.837296757
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.546135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.547505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.4419486331 9022650
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.8318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.8318551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.3518759878 11906362 8156756 2524372 12868966 14531868 11298694 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.953621924 2952479
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.7618551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.7618551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.7618692083 1440618 18289764 9022650 18648102 7440962 8291058 6679447 9653073 16192314 6482804 11289319 9328219
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.7617522070 16227642 16485898 17906064 12392966 11834606 11421492 14725611 2444490 11739529 10663392 14986274 10774834 19085960 17562736 16781746 19923254 12705907 15619225 11743745 16393943 16177239 11529661 11461765 14550746 16081117 12594235 12958197 12153990 10915739 19420014 18071297 18713872 19739265 19164858 11287661 19370779 15968718 12540782 16109766 19416960
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.183581430
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.746705139
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.507505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.026705139
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.5015034207
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.749022650 8074119
MESH:D007674 Kidney Diseases Acetaminophen 2.4015629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 14.4716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 14.4716705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 14.476582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4215034207 9327722
MESH:D008107 Liver Diseases Acetaminophen 1.7019784758 11587558 19460945 16611625 19014921 12587719 12969438 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6317185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.277678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.662876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.66598648 3712494 6587162 1399818
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D009336 Necrosis 2,4-dinitrotoluene 12.5418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 12.547678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.593581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.156679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 17.4716049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 17.4716049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 17.474026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.743988306
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.047296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.196228378
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.673692021
MESH:D012640 Seizures 2,4-dinitrotoluene 6.7418551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.7418551238
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.191399818 6587162 3712494 6582329 7505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 9.0316049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 9.0316049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 9.038074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 14.1910091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 14.1910091137
MESH:D014581 Urticaria Acetaminophen 3.4410982225
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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