AutismKB 2.0

Annotation Detail for HAVCR2


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Basic Information Top
Gene Symbol:HAVCR2 ( FLJ14428,KIM-3,TIM3,TIMD3,Tim-3 )
Gene Full Name: hepatitis A virus cellular receptor 2
Band: 5q33.3
Quick LinksEntrez ID:84868; OMIM: 606652; Uniprot ID:TIMD3_HUMAN; ENSEMBL ID: ENSG00000135077; HGNC ID: 18437
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of HAVCR2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of HAVCR2 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of HAVCR2 mRNAincreases expression 20458559
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of HAVCR2 mRNAdecreases expression 20064835
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 4.6111798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.6120127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.866695378
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.6419183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 4.1016206674
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9917474063 20146248
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.7911589617
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.8116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.813084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.8115073043 14691202 11135700 16217749 15553829
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.6019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.5112490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1320419170
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.6912609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.5818551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.5615213294
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 4.0221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0216485898 10915739 14550746 11287661 11743745 19739265 19420014 16081117 2444490 14986274 19164858 16781746 17562736 16109766 19923254 18071297 11739529 14725611 15619225 17906064 12392966 19085960 16393943 16227642 12705907 16177239 11529661 19416960 10774834 11461765 19370779 11834606 18713872 12958197 10663392 12594235 12540782 11421492 12153990 17522070 15968718
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.7012903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.7016530937
MESH:D005234 Fatty Liver arsenic trioxide 3.7115073043
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.7716904648
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8320471113
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D007674 Kidney Diseases Acetaminophen 2.4015629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.3216705839
MESH:D007938 Leukemia arsenic trioxide 3.0015070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.2217077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.9416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.7214633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.1919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1916467208 16968895 19850784 20471514 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4619642359 11161223 17107899 15622746 15213294 16330433 16891316 15336539 11468182 12018890 17712046 12679006 17649720 17869043 12712474 16331271 16823087 17217047 16112521 19225113 19035177 15748426 19075265 16966277 9834237
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.8616882451
MESH:D008107 Liver Diseases Acetaminophen 1.7016611625 12969438 19460945 19014921 12587719 19784758 16610002 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6317185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 4.9614682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.9621137059 20195826
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.9620377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.6615213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.5011798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.506695378 18816296 17053015 18569708 20064080 20464547 20869020 18520028 20135361
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5016381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3819417148 19549372 14977855 11468182 15949261
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.4018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3416882451 16105982
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.4918551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.4716624393
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3311141357
MESH:D009436 Neural Tube Defects arsenic trioxide 3.3610525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.8212819281 16049721
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.5019769630 16624393 12452020
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6315580305
MESH:D010235 Paraganglioma arsenic trioxide 4.6319927285
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.0919131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0917292933
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.4716646077
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7918551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5219755658 10029692
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4417007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4420155912 2093021
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.3919014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.5915213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 9.0416049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 9.0412845720 20435036 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 9.0417053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.9510091137
MESH:D014581 Urticaria Acetaminophen 3.4410982225
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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