AutismKB 2.0

Annotation Detail for PLXDC2


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Basic Information Top
Gene Symbol:PLXDC2 ( FLJ14623,TEM7R )
Gene Full Name: plexin domain containing 2
Band: 10p12.31
Quick LinksEntrez ID:84898; OMIM: 606827; Uniprot ID:PXDC2_HUMAN; ENSEMBL ID: ENSG00000120594; HGNC ID: 21013
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of PLXDC2 mRNAdecreases expression 19933214
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PLXDC2 mRNAdecreases expression 20064835
C006780 bisphenol A bisphenol A results in increased expression of PLXDC2 mRNAincreases expression 19371625
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PLXDC2 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of PLXDC2 mRNAdecreases expression 20106945
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of PLXDC2 mRNAincreases expression 19371625
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLXDC2 mRNAaffects cotreatment|increases expression 17942748
D015025 Zearalenone Zearalenone results in increased expression of PLXDC2 mRNAincreases expression 19371625
D015735 Mifepristone Mifepristone results in increased expression of PLXDC2 mRNAincreases expression 17584828
C059514 resveratrol resveratrol results in increased expression of PLXDC2 mRNAincreases expression 19371625
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLXDC2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PLXDC2 mRNAdecreases expression 19933214
C025643 vinclozolin vinclozolin affects the expression of PLXDC2 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0015322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D058186 Acute Kidney Injury resveratrol 3.9616538975
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2620464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2614692618
MESH:D000236 Adenoma Benzo(a)pyrene 7.016695378
MESH:D000236 Adenoma resveratrol 7.0115688382
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5316835633
MESH:D000544 Alzheimer Disease resveratrol 2.5916162502 16183991
MESH:D000686 Amyloidosis Diethylstilbestrol 4.6115469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D001008 Anxiety Disorders vinclozolin 3.7319015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.5815885639
MESH:D001169 Arthritis, Experimental resveratrol 7.5817115116
MESH:D050197 Atherosclerosis resveratrol 3.3316873680 17967414
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001862 Bone Resorption bisphenol A 3.9711985600
MESH:D002545 Brain Ischemia resveratrol 4.4417600658
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3717474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 2.3717123778
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.3715324884 17129689
MESH:D001943 Breast Neoplasms resveratrol 2.3716393696 17651959 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3720435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.923786805 16227642 16050911 15673190 16011737 18705752 10355542 16192424 16124888 16097048 15721981 15700767
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.8018788625
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 4.8015948411 16924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 4.8016227395 19321006
MESH:D002278 Carcinoma in Situ bisphenol A 5.1417123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.7516675471
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8220419170
MESH:D002294 Carcinoma, Squamous Cell resveratrol 4.8216227395
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases resveratrol 3.5515458977
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6012371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Cyclosporine 8.0519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0516105132 17681005 16919318 17110522 15861022 11677210 17333356
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1415668235 12621046 15340226 8697196 16354765
MESH:D003092 Colitis resveratrol 4.2716474422
MESH:D003110 Colonic Neoplasms resveratrol 2.4716338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1614669216 17141729
MESH:D003327 Coronary Disease resveratrol 3.8216507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 15322242 10048152
MESH:D003456 Cryptorchidism Diethylstilbestrol 11.8016002989 12952375
MESH:D003456 Cryptorchidism vinclozolin 11.8014966744
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.8616873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies resveratrol 4.0616286809
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.8219336974 21278145 6623471 4309450 3732212 19085960 3786805 7440962 10092053 15027814 7120509 10915739 15968718 6884620 11566570 16227642 15998439 17522070 9327722 7179309 16177239 2869522
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004487 Edema resveratrol 7.238985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0815322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.5512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 9.5517872969
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.8516402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.5315700306 16804899
MESH:D004715 Endometriosis Mifepristone 9.5016134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.509294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.9917923197
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0316530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.7116239168 12631006 17595544 19224547 16045604 12795759 61145 15959796
MESH:D005234 Fatty Liver Cyclosporine 13.7119224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.7115345470
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7215751030 16534752 16513791 16611131 16002989
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005355 Fibrosis Carbon Tetrachloride 15.5518705752
MESH:D005355 Fibrosis Cyclosporine 15.5512639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.5520067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0916973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4716417039
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.1016452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6311294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7219900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0316120746 12621046 15340226
MESH:D006561 Herpes Simplex resveratrol 4.3316876885
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2216959395 8697196 18606429 16354765 15340226
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6916899240
MESH:D006937 Hypercholesterolemia resveratrol 4.1117188708
MESH:D006949 Hyperlipidemias resveratrol 4.1416873680
MESH:D006965 Hyperplasia Diethylstilbestrol 4.5714722030 12960047
MESH:D006973 Hypertension Cyclosporine 5.0710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0718850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2315338365
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.4117488730
MESH:D007021 Hypospadias Diethylstilbestrol 11.7116002989
MESH:D007021 Hypospadias Ethinyl Estradiol 11.7116945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.7817600658
MESH:D007246 Infertility Diethylstilbestrol 4.4815036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.9017937319
MESH:D007248 Infertility, Male vinclozolin 6.9016467254
MESH:D007249 Inflammation resveratrol 5.2516366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2512878042 12200463
MESH:D007251 Influenza, Human resveratrol 4.7216624496
MESH:D007333 Insulin Resistance bisphenol A 3.3616393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.408314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 7.7612371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 7.7615003126 14681315 16762066
MESH:D007859 Learning Disorders Diethylstilbestrol 4.2017184923
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.6416087638
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8916417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8616943688 21278145 11408273 16239168 11903743 16221502 17157831 17174718 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3110355542 18376398 16097048 18210741 12586293 12667390 17869086 17823541 18420326 15925388 12741479 16192424 16011737 12546737 17721639 13678700 17922224 16248980 12958196 18395914 15996030 12445418 20821823 12898905 11481614 14716496 18279442 18418968 15650968 17631135 18395095 18412020 18472332 15931870 15959796 18251166 15893842 17766677 14724832 17640975 12609069 17525996 17900296 18006644 15052691 18187930 16638106 12632512 12649538 15338365 14748882 17761835 18705752 12445421 15057751 17698563 16116963 15730626 17944888 15818738 18317297 15876570 18263696 17805973 18429990 14512876 16027843 17557913 17565644 12632514 15123356 12666154 15362042 15370692 18339082 18156304 16136751 12389079 17976157 17708605 18472094 18054572 18277467 15673190 17481882 17714472 18205269 16015684 18481824 14620537 18166357 14716833 16033810
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3112878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1016964402 15720792 17285989 16246199 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3015123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7914706259 16899240
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.6720195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.6719294768
MESH:D008113 Liver Neoplasms Diethylstilbestrol 14.6716712894 15890375
MESH:D008113 Liver Neoplasms resveratrol 14.6720405173 19812893 19321006 19073162
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.6716984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.9812014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9812151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.2120464547 20869020 18569708 20064080 18520028 20135361 18816296 17053015 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2119555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.3015166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.5515700306
MESH:D016393 Lymphoma, B-Cell resveratrol 4.4217088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.9614749477
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.6916002989
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.4015688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 3.1811606380 8985016
MESH:D008545 Melanoma resveratrol 2.3817992120
MESH:D008659 Metabolic Diseases resveratrol 4.4917112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D009101 Multiple Myeloma resveratrol 3.5416490592 17164350 16267019 17049120 17935668 14749477
MESH:D009134 Muscular Atrophy, Spinal resveratrol 5.0217962980
MESH:D009203 Myocardial Infarction resveratrol 3.0717015251 16525036 16456233 17188708 16317513 17125593
MESH:D017202 Myocardial Ischemia resveratrol 9.3117015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.3112213967
MESH:D009205 Myocarditis resveratrol 4.9117322642
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2911141357
MESH:D009369 Neoplasms Diethylstilbestrol 5.2915313581
MESH:D009374 Neoplasms, Experimental resveratrol 4.148985016
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 17.1911399458 16427766
MESH:D009421 Nervous System Malformations Diethylstilbestrol 17.1911399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 17.1914600291
MESH:D019636 Neurodegenerative Diseases resveratrol 3.9017652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.5217929310
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.3717513867
MESH:D010049 Ovarian Diseases bisphenol A 5.1411985600
MESH:D010051 Ovarian Neoplasms Mifepristone 3.1516525653
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.3414722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.8116977796 15687265
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 32.3110548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 32.3117184923
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 32.3116679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 32.3111896295 11399792 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 32.3118042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.0918220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.3220887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0917292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.0916740699
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.0915046698 17136230 15846301
MESH:D011471 Prostatic Neoplasms resveratrol 2.0917804756 16731767 17675339 17718901 17636462 15767336
MESH:D011472 Prostatitis vinclozolin 5.0918629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.4716919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D011629 Puberty, Precocious bisphenol A 4.9410548101
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.7616325855
MESH:D015427 Reperfusion Injury resveratrol 3.3215827377 16314181 17520802 16317513 17058453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.7210029692 19755658
MESH:D012878 Skin Neoplasms resveratrol 9.728985016 15837718
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.7216192470
MESH:D013088 Spermatocele Diethylstilbestrol 12.3116002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 12.3116709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.5816321402
MESH:D019966 Substance-Related Disorders bisphenol A 4.1416684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D014062 Tongue Neoplasms resveratrol 4.3116227395
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2817053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 5.2816712894 17306315 16452187
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 10.0116175088
MESH:D002583 Uterine Cervical Neoplasms resveratrol 10.0117473185
MESH:D014591 Uterine Diseases bisphenol A 14.4114652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 14.4114652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 16.8415809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 16.8414692618
MESH:D014594 Uterine Neoplasms resveratrol 16.8417044934
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.5716513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.4417488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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