AutismKB 2.0

Annotation Detail for RGS5


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Basic Information Top
Gene Symbol:RGS5 ( MST092,MST106,MST129,MSTP032,MSTP092,MSTP106,MSTP129 )
Gene Full Name: regulator of G-protein signaling 5
Band: 1q23.3
Quick LinksEntrez ID:8490; OMIM: 603276; Uniprot ID:RGS5_HUMAN; ENSEMBL ID: ENSG00000143248; HGNC ID: 10001
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Related Diseases/Disorders Top
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Desease Name
Blood pressure regulation QTL
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C511295 2,2,4,4-tetrabromodiphenyl ether 2,2,4,4-tetrabromodiphenyl ether results in increased expression of RGS5 mRNAincreases expression 16488489
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of RGS5 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of RGS5 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of RGS5 mRNAincreases expression 20382639
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of RGS5 mRNAaffects expression 17484886
D003010 Clorgyline Clorgyline results in increased expression of RGS5 mRNAincreases expression 19691856
D004041 Dietary Fats Dietary Fats results in increased expression of RGS5 mRNAincreases expression 18042831
D004610 Ellagic Acid Ellagic Acid results in decreased expression of RGS5 mRNAdecreases expression 12002526
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of RGS5 mRNAaffects cotreatment|decreases expression 17404688
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of RGS5 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of RGS5 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of RGS5 mRNAaffects cotreatment|decreases expression 17942748
D005419 Flavonoids Flavonoids results in increased expression of RGS5 mRNAincreases expression 18035473
D005472 Fluorouracil Fluorouracil results in decreased expression of RGS5 mRNAdecreases expression 18157009
D005472 Fluorouracil IFNA1 protein promotes the reaction [Fluorouracil results in decreased expression of RGS5 mRNA]decreases expression|increases reaction 18157009
D017313 Fenretinide Fenretinide results in increased expression of RGS5 mRNAincreases expression 16671099
D007657 Ketone Bodies Ketone Bodies results in decreased expression of RGS5 mRNAdecreases expression 16807920
D008345 Manganese Manganese results in decreased expression of RGS5 mRNAdecreases expression 17175027
C025340 manganese chloride manganese chloride results in decreased expression of RGS5 mRNAdecreases expression 17175027
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of RGS5 mRNAincreases expression 17616710
C041786 palm oil palm oil results in increased expression of RGS5 mRNAincreases expression 18042831
C006253 pirinixic acid pirinixic acid results in decreased expression of RGS5 mRNAdecreases expression 17426115
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of RGS5 mRNAaffects cotreatment|decreases expression 17404688
D011794 Quercetin Quercetin results in increased expression of RGS5 mRNAincreases expression 16455785
C059514 resveratrol resveratrol results in decreased expression of RGS5 mRNAdecreases expression 12569576
D013629 Tamoxifen Tamoxifen affects the expression of RGS5 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin AHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of RGS5 mRNA]affects reaction|decreases expression 16891777
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of RGS5 mRNAaffects binding|decreases expression 16214954
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of RGS5 mRNAaffects cotreatment|decreases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of RGS5 mRNAdecreases expression 18796159
16891777
D014212 Tretinoin Tretinoin results in decreased expression of RGS5 mRNAdecreases expression 18230668
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3514745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6611752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7517505938
MESH:D058186 Acute Kidney Injury resveratrol 3.6816538975
MESH:D055371 Acute Lung Injury pirinixic acid 2.9418653653
MESH:D000230 Adenocarcinoma Estradiol 9.8011473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.8014692618
MESH:D000230 Adenocarcinoma Fenretinide 9.8010697514
MESH:D000230 Adenocarcinoma Fluorouracil 9.8017638652
MESH:D000236 Adenoma resveratrol 3.2115688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.2616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.2616835633
MESH:D000505 Alopecia Tretinoin 3.4615955085
MESH:D000544 Alzheimer Disease resveratrol 2.5316183991 16162502
MESH:D000740 Anemia Fluorouracil 8.1315504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.1311748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.0717084956
MESH:D000756 Anemia, Sideroblastic Manganese 10.4516910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 10.4516910769
MESH:D000799 Angioedema Acetaminophen 3.6510982225
MESH:D001161 Arteriosclerosis Dietary Fats 9.2815238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.2811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 11.6015885639
MESH:D001169 Arthritis, Experimental resveratrol 11.6017115116
MESH:D001169 Arthritis, Experimental Tretinoin 11.6016412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2216292516
MESH:D001249 Asthma Tretinoin 2.2916456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.7815336622
MESH:D050197 Atherosclerosis resveratrol 3.1616873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001327 Autoimmune Diseases Quercetin 4.2219761891
MESH:D001471 Barrett Esophagus Tretinoin 4.2216935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.2719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.2712125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 14.2716206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6415746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1417868700
MESH:D001930 Brain Injuries Progesterone 4.0715665606 15845082 15380490
MESH:D002545 Brain Ischemia resveratrol 4.0917600658
MESH:D001932 Brain Neoplasms Fenretinide 4.1816187019
MESH:D001943 Breast Neoplasms Dietary Fats 6.8220435547
MESH:D001943 Breast Neoplasms Estradiol 6.8212948864 17261762 17289903 17018787 14630087 18497071 19861407 16675129
MESH:D001943 Breast Neoplasms Fenretinide 6.8216601279
MESH:D001943 Breast Neoplasms Fluorouracil 6.8215136595 16557594 19217205 18357371 16110121 18608205 16595493
MESH:D001943 Breast Neoplasms Progesterone 6.8217614352 15562024 16175315
MESH:D001943 Breast Neoplasms Quercetin 6.8218628248
MESH:D001943 Breast Neoplasms resveratrol 6.8217534123 17651959 16393696
MESH:D001943 Breast Neoplasms Tamoxifen 6.8217242785 18351453 17049068 16202921 16818667 20005174 21138602 19142967 16273361 19059307 19487384 11161223 17261762 19289846 19244106 19011961 17893378 20135344 18815881 18855134 19288272 19084267 19066611 18984771 19410462 19115204 17440819 15668708 16873071 19103187 18997820 19155303 19221464 18629630 20544844 18425577 20390343 20859285 15565566 19189210 21152245 20065188 18821012 19189212 19200415
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.8220435547
MESH:D001943 Breast Neoplasms Tretinoin 6.8216443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4016813970
MESH:D002105 Cadmium Poisoning Quercetin 5.3516962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2716111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5910355542 16227642 3786805 15721981 18705752 16011737 16050911 16097048 16192424 15700767 15673190 16124888
MESH:D002276 Carcinoid Tumor Fluorouracil 4.4816051944
MESH:D002277 Carcinoma Fluorouracil 7.6917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.6916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3219066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9716168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 22.3416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 22.343084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 22.3418788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 22.3416924424
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 22.3416270382 17159502
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 22.3417045692 17088986 17971768 16332177 16799960 18930000
MESH:D006528 Carcinoma, Hepatocellular Quercetin 22.3412508355 19519916
MESH:D006528 Carcinoma, Hepatocellular resveratrol 22.3416227395 19321006
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 22.3416924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 22.341917145
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.4016675471
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.7717234771
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.9318695887
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 10.4016274795
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.4016757204 17066447 16280240 18986760
MESH:D002294 Carcinoma, Squamous Cell resveratrol 10.4016227395
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.4016051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4517572228
MESH:D006332 Cardiomegaly Quercetin 6.4519794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.4518670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases resveratrol 3.3415458977
MESH:D002386 Cataract Acetaminophen 6.8610977129
MESH:D002386 Cataract Tretinoin 6.8617460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.2120889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.2118566989
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 12.3316154183
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 12.3316129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0016835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.2811677210 17333356 15861022 17681005 16919318 16105132 17110522
MESH:D002779 Cholestasis pirinixic acid 7.2819176532
MESH:D002822 Choriocarcinoma Tretinoin 4.9716461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.5012621046 15668235 15340226 16354765 8697196
MESH:D002972 Cleft Palate Tretinoin 5.509407595
MESH:D003092 Colitis resveratrol 9.0016474422
MESH:D003092 Colitis Tretinoin 9.0017035595
MESH:D003110 Colonic Neoplasms Fluorouracil 5.7017172411 15001691 17287894 16510598 17018589 17725105 17016597 18772588 16340194 17169374
MESH:D003110 Colonic Neoplasms Quercetin 5.7011134977 19440933 16640504 15741050 17148506 17191121 19056647
MESH:D003110 Colonic Neoplasms resveratrol 5.7016338953
MESH:D015179 Colorectal Neoplasms Fenretinide 4.7117273769
MESH:D015179 Colorectal Neoplasms Fluorouracil 4.7118509181 17401013 16303861 16524972 18383874 15148649 17094418 16282729 18949393 20501625 17454858 18802399 17594712 16331619 17255274 18448328 17016601 17695437 14970324 18288408 15289873 16391804
MESH:D015179 Colorectal Neoplasms Quercetin 4.7118095365 18852136
MESH:D015179 Colorectal Neoplasms resveratrol 4.7116550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9014669216 17141729
MESH:D003327 Coronary Disease resveratrol 3.6316507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.3920055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.399125849 9664655 8800419 17551590 9142499 16925845 9224671 14991402 9211117 10589399
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.8318551238
MESH:D007644 Darier Disease Fluorouracil 4.6016733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1719031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3418249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 8.0419496084
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 8.0416873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6217107852
MESH:D003928 Diabetic Nephropathies Estradiol 14.0919279558
MESH:D003928 Diabetic Nephropathies resveratrol 14.0916286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 14.0919279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.3017187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.4621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.4611461765 14550746 12392966 11529661 17562736 10663392 12958197 10915739 19739265 12153990 16177239 2444490 12705907 15619225 16485898 12540782 19370779 12594235 11421492 19164858 15968718 11739529 16781746 17906064 14725611 19420014 16227642 18713872 19416960 11287661 11834606 18071297 10774834 19923254 16081117 11743745 19085960 14986274 16393943 16109766 17522070
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.466623471 10092053 16227642 21278145 7440962 4309450 3786805 2869522 7120509 9327722 15998439 16177239 7179309 10915739 19336974 15968718 6884620 19085960 3732212 17522070 11566570 15027814
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.4620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6211462148
MESH:D050171 Dyslipidemias Dietary Fats 3.3218367378
MESH:D004487 Edema pirinixic acid 10.4412083418
MESH:D004487 Edema resveratrol 10.448985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.4411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.3016714409 18230668 15322242
MESH:D004489 Edema, Cardiac Tretinoin 11.3018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 20.4112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 20.4117692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 20.4117872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 20.4119031437
MESH:D016889 Endometrial Neoplasms Estradiol 11.7118566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.7117893378 19155303 20544844 16202921
MESH:D016889 Endometrial Neoplasms Tretinoin 11.7116569247
MESH:D004715 Endometriosis Progesterone 8.3716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.379294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.6617923197
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.0420426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.0416481741 16785472 16337965 15173087 17638652
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 7.0415547733 15623463 15264214 15150132 16510608 15547721 15878914 16805852 16704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.3711564622
MESH:D005124 Eye Abnormalities Tretinoin 8.379664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 22.8061145 17595544 15959796 19224547 12795759 16239168 16045604 12631006
MESH:D005234 Fatty Liver Dietary Fats 22.8018296743 19551842 19004024 17967931
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.8015345470
MESH:D005234 Fatty Liver pirinixic acid 22.8019236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 22.8014986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9919069698
MESH:D005355 Fibrosis Carbon Tetrachloride 25.7318705752
MESH:D005355 Fibrosis Dietary Fats 25.7318296743
MESH:D005355 Fibrosis Quercetin 25.7319474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 25.7320067830
MESH:D005355 Fibrosis Tretinoin 25.7317994277
MESH:D005756 Gastritis Acetaminophen 3.4816983495
MESH:D005909 Glioblastoma Fenretinide 16.0216187019
MESH:D005909 Glioblastoma Manganese 16.0217043766
MESH:D005909 Glioblastoma Quercetin 16.0219804834
MESH:D005909 Glioblastoma Tretinoin 16.0217312396
MESH:D005910 Glioma Fluorouracil 5.9416145905
MESH:D005910 Glioma Quercetin 5.9417643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4010696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.3715102660 15162350 18337622
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.3716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9716084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.2010048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.209664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.4220558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1611000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4119900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 7.6318467677 19176532 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.6315340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.8415709030
MESH:D006561 Herpes Simplex resveratrol 3.9916876885
MESH:D019584 Hot Flashes Estradiol 3.5617088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.858697196 18606429 16959395 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 7.1316870215
MESH:D006930 Hyperalgesia Tretinoin 7.1316870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3416899240
MESH:D006937 Hypercholesterolemia Dietary Fats 8.6421332399
MESH:D006937 Hypercholesterolemia resveratrol 8.6417188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3816778211
MESH:D006943 Hyperglycemia pirinixic acid 8.6920558911
MESH:D006943 Hyperglycemia Quercetin 8.6911834736 18262572
MESH:D006949 Hyperlipidemias Dietary Fats 8.7021332399
MESH:D006949 Hyperlipidemias resveratrol 8.7016873680
MESH:D006973 Hypertension Quercetin 4.9818356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9818850075 18670907
OMIM:145500 HYPERTENSION, ESSENTIAL marker/mechanism
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9015338365
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.1317488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6216945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 10.8515869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 10.8517600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3617937319
MESH:D007249 Inflammation Dietary Fats 18.6920412841
MESH:D007249 Inflammation Flavonoids 18.6917296493
MESH:D007249 Inflammation Progesterone 18.6915869954
MESH:D007249 Inflammation resveratrol 18.6916366677
MESH:D007249 Inflammation Tamoxifen 18.6919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 18.6912878042 12200463
MESH:D007251 Influenza, Human Quercetin 10.5516624496
MESH:D007251 Influenza, Human resveratrol 10.5516624496
MESH:D007333 Insulin Resistance Dietary Fats 11.5818457598 11836018
MESH:D007333 Insulin Resistance Estradiol 11.5816393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.5816306350
MESH:D007410 Intestinal Diseases Tretinoin 3.5817994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.3616580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.3615992940 17551590
MESH:D007627 Keloid Quercetin 4.7717086741
MESH:D007674 Kidney Diseases Acetaminophen 9.4415629191 12587719
MESH:D007674 Kidney Diseases Estradiol 9.4415618244
MESH:D007674 Kidney Diseases Quercetin 9.4416962696
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 16.4916705839
MESH:D007680 Kidney Neoplasms Estradiol 16.4915610895
MESH:D007680 Kidney Neoplasms Fluorouracil 16.4916985049
MESH:D007680 Kidney Neoplasms Tamoxifen 16.4918625569
MESH:D007938 Leukemia Quercetin 6.1517468513
MESH:D007938 Leukemia Tretinoin 6.1517143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.5316482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0517596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 7.3616087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.369834237 17294898 19035177 15748426 17107899 16935935 19075265 16766008 17649720 19225113 16140955 16788101 17712046 16823087 17339181 12679006 17361223 16331271 16891316 17301526 19642359 17506722 17217047 19029980 17368321
MESH:D007972 Leukoplakia, Oral Fenretinide 5.8516707609
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.179224671
MESH:D008064 Lipidoses Tamoxifen 3.0215342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.2817174718 17157831 16221502 16943688 21278145 17334410 11408273 16239168 11903743
MESH:D008103 Liver Cirrhosis Dietary Fats 6.2818296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 10.5517944888 14748882 10355542 15996030 18054572 16027843 12666154 17708605 15876570 18277467 17565644 12649538 15052691 16136751 15650968 18395914 17900296 18210741 17823541 17869086 15925388 15818738 18705752 15673190 17631135 15730626 16192424 17922224 12632512 12586293 15931870 16638106 14512876 12546737 16097048 18429990 14724832 18251166 14716496 18472094 20821823 16248980 18481824 18412020 18317297 17761835 16033810 17557913 12667390 15362042 17525996 17714472 18205269 18339082 18187930 15123356 13678700 15338365 18420326 12632514 18418968 17481882 18395095 12741479 17640975 17805973 15370692 18376398 12609069 18472332 16116963 12898905 18156304 17976157 11481614 12445418 16015684 15893842 15057751 14620537 17766677 12445421 16011737 14716833 18263696 17698563 12389079 18166357 18006644 15959796 12958196 18279442 17721639
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.5514716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 10.5515474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 10.5512741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 10.5518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.5512878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 10.5516248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 3.7319784758 19460945 16610002 19014921 16611625 12969438 11587558 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.7315720792 16964402 15830285 17285989 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.8517185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.8516899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 20.7919294768
MESH:D008113 Liver Neoplasms Fluorouracil 20.7915113037 16603448 18383874 17045692
MESH:D008113 Liver Neoplasms pirinixic acid 20.7916377806 15890375 20007298
MESH:D008113 Liver Neoplasms Quercetin 20.7918980244
MESH:D008113 Liver Neoplasms resveratrol 20.7919073162 20405173 19812893 19321006
MESH:D008113 Liver Neoplasms Tamoxifen 20.7916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.7916984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.1712014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Quercetin 9.1719519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.1712151625
MESH:D008175 Lung Neoplasms Fluorouracil 4.6715246190
MESH:D008175 Lung Neoplasms Quercetin 4.6716280456
MESH:D008175 Lung Neoplasms Tamoxifen 4.6718625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.6719555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.6015086387
MESH:D016393 Lymphoma, B-Cell resveratrol 4.1217088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.7114749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 9.3615688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 9.3619428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 17.5517203775 11807958 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 17.5510697514
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 17.5511408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 17.5511606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 17.5511731420 19196723 14580682 16827153 19196722
MESH:D020149 Manganese Poisoning Estradiol 21.2719453300
MESH:D020149 Manganese Poisoning Manganese 21.2716568477 19453300 16551646
MESH:D020149 Manganese Poisoning Tamoxifen 21.2719453300
MESH:D008527 Medulloblastoma Tretinoin 2.7117453147
MESH:D008545 Melanoma Fenretinide 7.0616270382
MESH:D008545 Melanoma resveratrol 7.0617992120
MESH:D008545 Melanoma Tamoxifen 7.0612393984 19393235
MESH:D008545 Melanoma Tretinoin 7.0616752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3819513568
MESH:D008591 Meningomyelocele Tretinoin 4.2416940565
MESH:D008659 Metabolic Diseases resveratrol 4.2017112576
MESH:D009062 Mouth Neoplasms Fenretinide 8.4616274795
MESH:D009062 Mouth Neoplasms Fluorouracil 8.4618986760 16757204
MESH:D009069 Movement Disorders Manganese 4.8316551646
MESH:D009101 Multiple Myeloma resveratrol 3.3314749477 17049120 17935668 16267019 17164350 16490592
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.6817962980
MESH:D009135 Muscular Diseases pirinixic acid 3.3216239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9717596541
MESH:D009203 Myocardial Infarction pirinixic acid 9.0519151258
MESH:D009203 Myocardial Infarction Quercetin 9.0519595682
MESH:D009203 Myocardial Infarction resveratrol 9.0517015251 16456233 17125593 16317513 17188708 16525036
MESH:D017202 Myocardial Ischemia resveratrol 8.5117015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.5112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.3516810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.3516411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 13.3519207477
MESH:D009205 Myocarditis resveratrol 4.5717322642
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.6718551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4519410462
MESH:D009369 Neoplasms Fenretinide 14.7515958647 17353921
MESH:D009369 Neoplasms Fluorouracil 14.7516928823 18600527 18239605
MESH:D009369 Neoplasms pirinixic acid 14.7517405874
MESH:D009369 Neoplasms Quercetin 14.7515185748
MESH:D009369 Neoplasms Tretinoin 14.7516946489 16594593
MESH:D009374 Neoplasms, Experimental resveratrol 3.818985016
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8119200415 19189210 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5417289903
MESH:D009410 Nerve Degeneration Manganese 4.1316551646
MESH:D009421 Nervous System Malformations Estradiol 15.2616427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.2614600291
MESH:D009421 Nervous System Malformations Tretinoin 15.269125849
MESH:D009436 Neural Tube Defects Tretinoin 2.939142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.8418514411
MESH:D019636 Neurodegenerative Diseases resveratrol 7.8417652729
MESH:D020078 Neurogenic Inflammation Quercetin 10.1017929310
MESH:D020078 Neurogenic Inflammation resveratrol 10.1017929310
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.4916303764
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3116436463
MESH:D009765 Obesity Dietary Fats 4.2717217161 19632207 11836018 21332399 20518802 20132043 16723640 18457598 18674790
MESH:D009765 Obesity pirinixic acid 4.2720558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.2616049721 12819281
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 9.6119495926
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 9.6117513867
MESH:D010051 Ovarian Neoplasms Estradiol 14.3519401270
MESH:D010051 Ovarian Neoplasms Fenretinide 14.3516133793
MESH:D010051 Ovarian Neoplasms Progesterone 14.3517393432 16525653
MESH:D010051 Ovarian Neoplasms Quercetin 14.3519005980
MESH:D010051 Ovarian Neoplasms Tretinoin 14.3516936753
MESH:D010146 Pain Acetaminophen 6.0816870215
MESH:D010146 Pain Tretinoin 6.0816870215
MESH:D010190 Pancreatic Neoplasms Fenretinide 11.8315580305
MESH:D010190 Pancreatic Neoplasms Fluorouracil 11.8319003803 16929163 15113037 16500647
MESH:D010190 Pancreatic Neoplasms Quercetin 11.8316965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 11.8315976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5111578682
MESH:D010300 Parkinson Disease Manganese 3.3011181820
MESH:D020734 Parkinsonian Disorders Manganese 4.3016140633
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0612520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3718163543
MESH:D011230 Precancerous Conditions Quercetin 3.8219056647
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 8.9516679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.9511222880 11118676 11399792 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7120887781
MESH:D011471 Prostatic Neoplasms Clorgyline 2.0819691856
MESH:D011471 Prostatic Neoplasms Estradiol 2.0816740699
MESH:D011471 Prostatic Neoplasms Fenretinide 2.0817024972
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0819082440 18626508
MESH:D011471 Prostatic Neoplasms Quercetin 2.0817292933 14715546
MESH:D011471 Prostatic Neoplasms resveratrol 2.0817636462 17675339 17718901 16731767 15767336 17804756
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0815067354
MESH:D011507 Proteinuria Tretinoin 3.4316636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.1215861022 16919318
MESH:D011625 Pterygium Tretinoin 4.6016723453
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8516160472 18286688 15538739 18722050
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.3916325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.2619058328
MESH:D015427 Reperfusion Injury resveratrol 6.2615827377 16314181 17058453 17520802 16317513
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6518990726
MESH:D012162 Retinal Degeneration Fenretinide 4.2616303925
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9216116481 16283617
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7918045962
MESH:D012554 Schistosomiasis japonica Quercetin 5.3516862918
MESH:D012640 Seizures 2,4-dinitrotoluene 2.4118551238
MESH:D012878 Skin Neoplasms Fenretinide 12.8816467112
MESH:D012878 Skin Neoplasms resveratrol 12.888985016 15837718
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.8816192470
MESH:D012878 Skin Neoplasms Tretinoin 12.8816467112
MESH:D013088 Spermatocele Ethinyl Estradiol 10.9216709447
MESH:D013088 Spermatocele Tamoxifen 10.9216709447
MESH:D013119 Spinal Cord Injuries Progesterone 10.2315862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 10.2319457130
MESH:D013274 Stomach Neoplasms Fluorouracil 3.3619084572 16424979 15786421 18396642 17172411 19015929 18567086 16951190 17498489 17522103
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 3.3617575124 12958204
MESH:D013274 Stomach Neoplasms Tretinoin 3.3617261132
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.3116321402
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7112697716
MESH:D013964 Thyroid Neoplasms Tretinoin 2.8817045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.4919048282
MESH:D014062 Tongue Neoplasms Fluorouracil 15.6116280240
MESH:D014062 Tongue Neoplasms resveratrol 15.6116227395
MESH:D014062 Tongue Neoplasms Tretinoin 15.6116051514
MESH:D014376 Tuberculosis Tretinoin 3.1116040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.3716049721
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 11.3716720286
MESH:D001749 Urinary Bladder Neoplasms Quercetin 11.3716720314
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.378653321 17572228 16712894
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.1210091137
MESH:D014581 Urticaria Acetaminophen 2.8010982225
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 21.2916154183
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 21.2916803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 21.2917473185
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 21.2916129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.8914692618
MESH:D014594 Uterine Neoplasms resveratrol 8.8917044934
MESH:D014604 Uveal Neoplasms Tretinoin 4.4216752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4012125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3714671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.1117488730
MESH:D014820 Vitiligo Tretinoin 3.8716761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0615886252
MESH:D015430 Weight Gain Dietary Fats 3.5816723640
MESH:D009396 Wilms Tumor Tretinoin 3.8116287080
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA34376
    • No data
    Releated disease ID Related disease Name
    PA444552Hypertension
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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