AutismKB 2.0

Annotation Detail for LRP11


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:LRP11 ( FLJ14735,MANSC3,MGC39092,bA350J20.3 )
Gene Full Name: low density lipoprotein receptor-related protein 11
Band: 6q25.1
Quick LinksEntrez ID:84918; OMIM: NA; Uniprot ID:LRP11_HUMAN; ENSEMBL ID: ENSG00000120256; HGNC ID: 16936
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of LRP11 mRNAaffects expression 18648102
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of LRP11 proteinaffects expression 20106945
C068073 Am 580 Am 580 results in decreased expression of LRP11 mRNAdecreases expression 16982809
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of LRP11 mRNAincreases expression 20106945
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of LRP11 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of LRP11 mRNAincreases expression 19482888
C089730 rosiglitazone rosiglitazone results in decreased expression of LRP11 mRNAdecreases expression 16982809
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of LRP11 mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.656195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.6515322242 11752688 14514962
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420127859 20464547
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.093712494
MESH:D000236 Adenoma Benzo(a)pyrene 7.096695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.4417620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.4416835633
MESH:D000544 Alzheimer Disease rosiglitazone 2.9019621015
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.461440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8720146248 17474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.817296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.8112907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.816705139 17173139 1701930 20007298 20935162
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.787296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1120419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5016120746 18670907 18850075
MESH:D002386 Cataract Am 580 4.4917460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.947505956
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.614080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.359022650 19486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2012621046 15340226 15668235 8697196 16354765
MESH:D003092 Colitis Am 580 5.3217035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1518759878 11298694 8156756 2524372 12868966 14531868 11906362 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.792952479 3621924
MESH:D003920 Diabetes Mellitus rosiglitazone 4.5517446233
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 4.6812642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.6817107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.928291058 9328219 6679447 18692083 9653073 18289764 9022650 1440618 7440962 16192314 18648102 11289319 6482804
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004421 Dystonia Phenobarbital 4.311851702
MESH:D004487 Edema rosiglitazone 7.9112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.9112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3515322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.299294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.473659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.313922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.796401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.617750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.413659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.563581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver rosiglitazone 4.2119196556
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.466705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.347505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.8820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8811294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.846705139
MESH:D006529 Hepatomegaly Phenobarbital 9.6616109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.6612621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.498697196 18606429 16959395 16354765 15340226
MESH:D006930 Hyperalgesia rosiglitazone 4.1412083418
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3015034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918850075 18670907
MESH:D007249 Inflammation rosiglitazone 5.6012083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.6012200463 12878042
MESH:D007333 Insulin Resistance rosiglitazone 3.9716306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.468074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.206582329
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0321047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.359327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 2.6317347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.6312878042
MESH:D008107 Liver Diseases Phenobarbital 2.2219363144
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.4418177683 9163691 2125692 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.4420195826 21137059
MESH:D008113 Liver Neoplasms Phenobarbital 11.4419812893 19482888 19073162 15975961 8742319 21047994
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.4416984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 15.48598648 1399818 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 15.488603461
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 15.4818308698 1399818 6150874 17172636 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.4812151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.5014755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5018816296 6695378 18569708 20135361 20464547 17053015 20064080 18520028 20869020
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5019555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 3.5516827153
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.6117261469
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8717484760
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.563581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2811141357
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.086679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.686482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.463988306
MESH:D010018 Osteomalacia Phenobarbital 4.7617016548
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5716965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.847296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.916228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.872563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911399792 11118676 11222880 11896295
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9317292933
MESH:D019310 Pseudolymphoma Phenobarbital 4.9412752131
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.583692021
MESH:D012640 Seizures Phenobarbital 2.8716876388 3137016 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.226407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.8519755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8516192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.856582329 7505956 6587162 1399818 3712494
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.851399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.278074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2717053015
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved