AutismKB 2.0

Annotation Detail for PPM1D


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Basic Information Top
Gene Symbol:PPM1D ( PP2C-DELTA,WIP1 )
Gene Full Name: protein phosphatase, Mg2+/Mn2+ dependent, 1D
Band: 17q23.3
Quick LinksEntrez ID:8493; OMIM: 605100; Uniprot ID:PPM1D_HUMAN; ENSEMBL ID: ENSG00000170836; HGNC ID: 9277
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04115p53 signaling pathway
No data
Pathway IDPathway Name
200175p53 pathway
Pathway IDPathway Name
P04398p53 pathway feedback loops 2
P00059p53 pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of PPM1D mRNAincreases expression 16788091
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in decreased expression of PPM1D mRNAdecreases expression 16514628
D000082 Acetaminophen Acetaminophen affects the expression of PPM1D mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of PPM1D proteinaffects expression 20106945
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of PPM1D mRNAincreases expression 18687144
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PPM1D mRNAincreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PPM1D mRNAincreases expression 20382639
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of PPM1D mRNAincreases expression 12414654
D004642 Emodin Emodin results in increased expression of PPM1D mRNAincreases expression 16045814
D004958 Estradiol Estradiol results in increased expression of PPM1D mRNAincreases expression 16514628
D005472 Fluorouracil Fluorouracil results in increased expression of PPM1D mRNAincreases expression 17982676
D005472 Fluorouracil Fluorouracil results in increased expression of PPM1D proteinincreases expression 14665630
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in increased expression of PPM1D mRNA]affects reaction|increases expression 15016801
D005472 Fluorouracil TP53 protein promotes the reaction [Fluorouracil results in increased expression of PPM1D mRNA]increases expression|increases reaction 17982676
C070081 fulvestrant fulvestrant results in decreased expression of PPM1D mRNAdecreases expression 16514628
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of PPM1D mRNAincreases expression 12414654
C051890 irinotecan irinotecan analog results in increased expression of PPM1D mRNAincreases expression 18927307
D009569 Nitric Oxide Nitric Oxide results in increased expression of PPM1D mRNAincreases expression 15126337
D019800 Phenol Phenol results in increased expression of PPM1D mRNAincreases expression 17547211
D020849 Raloxifene Raloxifene results in decreased expression of PPM1D mRNAdecreases expression 16514628
D018038 Sodium Selenite Sodium Selenite results in increased expression of PPM1D mRNAincreases expression 18175754
D024483 Vitamin K 3 Vitamin K 3 results in increased expression of PPM1D mRNAincreases expression 12414654
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.9920464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 6.9911473722
MESH:D000230 Adenocarcinoma Fluorouracil 6.9917638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.616695378
MESH:D000419 Albuminuria Raloxifene 4.5317308373 17451421
MESH:D000544 Alzheimer Disease Nitric Oxide 4.6417556102
MESH:D000544 Alzheimer Disease Raloxifene 4.6415800139
MESH:D000740 Anemia Fluorouracil 3.6517963324 16511603 15504547
MESH:D000799 Angioedema Acetaminophen 3.7910982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0119183758
MESH:D001284 Atrophy fulvestrant 4.7811514358
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001859 Bone Neoplasms Phenol 5.1410556009
MESH:D001913 Bowen's Disease Phenol 5.7019293009
MESH:D001930 Brain Injuries Raloxifene 4.4116580743
MESH:D001943 Breast Neoplasms marker/mechanism
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9420146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 2.9412948864 19861407 17261762 16675129 17018787 18497071 17289903 14630087
MESH:D001943 Breast Neoplasms Fluorouracil 2.9419217205 16110121 15136595 16595493 18608205 18357371 16557594
MESH:D001943 Breast Neoplasms fulvestrant 2.9418984771
MESH:D001943 Breast Neoplasms Nitric Oxide 2.9415631943
MESH:D001943 Breast Neoplasms Raloxifene 2.9416912660 17595753 16837676 15572757 17242785 15775269 15758505 17952589 17261762 17049068 17440819 17893378
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4016111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.6116051944
MESH:D002277 Carcinoma Fluorouracil 3.5117121937
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.483084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.4821507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.4816924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.4816799960 18930000 17088986 17045692 17971768 16332177
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.9918695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.5820419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.5818986760 17066447 16757204 16280240
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.0117572228
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 7.4216936243
MESH:D002318 Cardiovascular Diseases Raloxifene 7.4215775269
MESH:D002386 Cataract Acetaminophen 2.5410977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.4920889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.4918566989
MESH:D002779 Cholestasis Nitric Oxide 4.4016919318
MESH:D019457 Chromosome Breakage Sodium Selenite 4.6915894690
MESH:D003072 Cognition Disorders Raloxifene 4.5515800139
MESH:D003110 Colonic Neoplasms Fluorouracil 3.9217169374 17725105 16510598 18772588 17287894 16340194 17016597 17018589 17172411 15001691
MESH:D003110 Colonic Neoplasms irinotecan 3.9217725105 17287894
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.7115289873 20501625 18509181 16524972 17401013 17094418 18383874 18448328 16331619 16391804 16282729 18802399 17695437 17255274 14970324 18949393 17454858 17016601 16303861 17594712 15148649 18288408
MESH:D015179 Colorectal Neoplasms irinotecan 2.7118259882 17454858 16391804 15273666 17159606 18509181 16303861
MESH:D007644 Darier Disease Fluorouracil 4.7316733453
MESH:D015140 Dementia, Vascular Nitric Oxide 5.9017556102
MESH:D003865 Depressive Disorder, Major Raloxifene 4.1017474826
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.7216285004
MESH:D003928 Diabetic Nephropathies Estradiol 8.8119279558
MESH:D003928 Diabetic Nephropathies Raloxifene 8.8115920148 17451421 17308373
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.7715968718 11739529 11461765 17562736 18071297 18713872 14725611 19923254 16781746 12594235 19739265 16485898 11529661 12392966 17522070 10774834 11421492 16109766 10663392 16177239 12705907 16227642 17906064 19370779 10915739 16393943 12958197 2444490 11287661 16081117 14550746 14986274 19416960 15619225 12540782 11743745 19085960 11834606 19164858 12153990 19420014
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 3.7715131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0419426721
MESH:D004487 Edema Raloxifene 3.2815860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 3.9315845917
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 7.6419148513
MESH:D016889 Endometrial Neoplasms Estradiol 7.6411473722 18566989 19148513
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.1320426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.1316530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.1315173087 17638652 16337965 16481741 16785472
MESH:D005234 Fatty Liver Raloxifene 3.5617473493
MESH:D005355 Fibrosis Emodin 4.7419474275
MESH:D005756 Gastritis Acetaminophen 3.6216983495
MESH:D005910 Glioma Fluorouracil 2.8416145905
MESH:D006261 Headache Nitric Oxide 5.1211554966 11284996
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.3415162350 18337622 15102660
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6220471113
MESH:D006331 Heart Diseases Raloxifene 3.4911110106
MESH:D006558 Herpes Genitalis Estradiol 4.9815709030
MESH:D019584 Hot Flashes Estradiol 3.7017088409
MESH:D006930 Hyperalgesia Acetaminophen 2.6516870215
MESH:D006940 Hyperemia Nitric Oxide 5.5511156591
MESH:D006973 Hypertension Raloxifene 2.8415787275 17577099
MESH:D006976 Hypertension, Pulmonary Nitric Oxide 4.3715838368
MESH:D007248 Infertility, Male fulvestrant 3.7011514358
MESH:D007333 Insulin Resistance Estradiol 7.2916627594 16393666
MESH:D007333 Insulin Resistance Sodium Selenite 7.2914714311
MESH:D007410 Intestinal Diseases Nitric Oxide 4.8711574821 10210152 11713966
MESH:D055623 Keratosis, Actinic Phenol 6.3919293009
MESH:D007674 Kidney Diseases Acetaminophen 5.7615629191 12587719
MESH:D007674 Kidney Diseases Estradiol 5.7615618244
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.2116518626
MESH:D007680 Kidney Neoplasms Estradiol 7.3015610895
MESH:D007680 Kidney Neoplasms Fluorouracil 7.3016985049
MESH:D007889 Leiomyoma Raloxifene 4.4316973256
MESH:D007896 Leishmaniasis Nitric Oxide 4.6017218153
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Emodin 4.9617077332
MESH:D008106 Liver Cirrhosis, Experimental Emodin 2.9215288473
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.9214659978 14716833
MESH:D008107 Liver Diseases Acetaminophen 1.6112969438 19784758 12587719 19460945 16610002 19014921 16611625 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1817185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.342125692 18177683 9163691 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.3420195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 7.3415113037 16603448 17045692 18383874
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.708603461
MESH:D055370 Lung Injury Asbestos, Crocidolite 9.3517365036
MESH:D055370 Lung Injury Nitric Oxide 9.3511395602
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4214755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4220064080 18520028 20869020 17053015 18569708 20464547 18816296 20135361 6695378
MESH:D008175 Lung Neoplasms Fluorouracil 3.4215246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.7315086387
MESH:D008223 Lymphoma Nitric Oxide 4.2316166326
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.0014737004
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.5217203775 11807958 16891317 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.4319453300
MESH:D008545 Melanoma Vitamin K 3 3.1719082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5019513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.1618303189 16166281 16966607
MESH:D008881 Migraine Disorders Nitric Oxide 4.2311701602
MESH:D020326 Migraine without Aura Nitric Oxide 5.0514659530 11304026
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.5015863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.3616381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.3616757204 18986760
MESH:D052016 Mucositis irinotecan 4.9517159606
MESH:D009101 Multiple Myeloma Raloxifene 3.3916497877
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.2316810080
MESH:D009232 Myxoma Raloxifene 5.5016343187
MESH:D009362 Neoplasm Metastasis irinotecan 3.1418259882
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9611141357
MESH:D009369 Neoplasms Fluorouracil 4.9618600527 16928823 18239605
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6717289903
MESH:D009421 Nervous System Malformations Estradiol 3.5911399458 16427766
MESH:D009447 Neuroblastoma irinotecan 3.458761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8118514411
MESH:D017599 Neuroectodermal Tumors irinotecan 4.678761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3916436463
MESH:D010024 Osteoporosis Raloxifene 3.3517882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.1615758505 15579764 17823083 17893378
MESH:D010051 Ovarian Neoplasms Estradiol 2.2019401270
MESH:D010146 Pain Acetaminophen 6.8716870215
MESH:D010146 Pain Phenol 6.8717610455
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.6416500647 19003803 15113037 16929163
MESH:D010212 Papilloma Hydrogen Peroxide 4.0212065085
MESH:D010392 Pemphigus Phenol 6.3916522979 17163923
MESH:D010864 Pilonidal Sinus Phenol 6.3919655223 15622588
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.8310923243
MESH:D011015 Pneumonia, Aspiration Nitric Oxide 5.2718573544
MESH:D011041 Poisoning Phenol 4.658825745
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8220887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8717292933
MESH:D011471 Prostatic Neoplasms Estradiol 1.8716740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8718626508 19082440
MESH:D011471 Prostatic Neoplasms Raloxifene 1.8716536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms Sodium Selenite 1.8718760546
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0017975199 15814490 17365031 17322281
MESH:D011693 Purpura Raloxifene 5.5015770314
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9516160472 18286688 15538739 18722050
MESH:D012555 Schistosomiasis mansoni Nitric Oxide 5.379673227
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.3610029692 19755658
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 9.3612065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.368532709
MESH:D013088 Spermatocele Phenol 5.5818646496
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.402093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 3.4017498489 18396642 15786421 17522103 18567086 16424979 16951190 19084572 17172411 19015929
MESH:D013274 Stomach Neoplasms irinotecan 3.4015723263
MESH:D013276 Stomach Ulcer Nitric Oxide 4.1315138204
MESH:D020521 Stroke Raloxifene 3.7716837676
MESH:D013978 Tibial Fractures Estradiol 13.5319048282
MESH:D013978 Tibial Fractures Raloxifene 13.5319048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.9316280240
MESH:D014277 Trigeminal Neuralgia Phenol 6.3916527771 10223447
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.0817053015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.0817572228
MESH:D014581 Urticaria Acetaminophen 2.9110982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.8216803524
MESH:D054556 Venous Thromboembolism Raloxifene 5.1516837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.5016343187
MESH:D014860 Warts Phenol 6.0419122958
Pathway ID Pathway Name
KEGG:04115 p53 signaling pathway
Pharmacogenomics Knowledge Base Top
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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