AutismKB 2.0

Annotation Detail for MASTL


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Basic Information Top
Gene Symbol:MASTL ( FLJ14813,RP11-85G18.2,THC2 )
Gene Full Name: microtubule associated serine/threonine kinase-like
Band: 10p12.1
Quick LinksEntrez ID:84930; OMIM: 608221; Uniprot ID:MASTL_HUMAN; ENSEMBL ID: ENSG00000120539; HGNC ID: 19042
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of MASTL proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of MASTL mRNAincreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MASTL mRNAdecreases expression 20382639
C006780 bisphenol A bisphenol A results in increased expression of MASTL mRNAincreases expression 16474171
D016572 Cyclosporine Cyclosporine results in decreased expression of MASTL mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of MASTL mRNAincreases expression 16474171
D019833 Genistein Genistein results in increased expression of MASTL mRNAincreases expression 16474171
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of MASTL mRNAincreases expression 20713471
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of MASTL mRNAincreases expression 16474171
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MASTL mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0811752688 15322242 14514962
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.3220127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 7.3211473722
MESH:D000230 Adenocarcinoma Genistein 7.3211473722
MESH:D000236 Adenoma Benzo(a)pyrene 7.186695378
MESH:D000236 Adenoma Methylcholanthrene 7.1810545420 6695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D050197 Atherosclerosis Methylcholanthrene 3.5511922910
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001862 Bone Resorption bisphenol A 4.0311985600
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.0320146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 3.0317123778
MESH:D001943 Breast Neoplasms Estradiol 3.0317261762 12948864 18497071 17289903 14630087 17018787 16675129 19861407
MESH:D001943 Breast Neoplasms Genistein 3.0316873071 17200150 16541309
MESH:D001943 Breast Neoplasms Methylcholanthrene 3.0317474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.0320435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7016111702
MESH:D002277 Carcinoma Methylcholanthrene 8.8010545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.8016835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.7721507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7716924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.7716924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.2317123778
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0920419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Genistein 3.4216332659
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 17.0120889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 17.0112371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 17.0118566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 17.0116192471
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Cyclosporine 3.0419486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1615340226 12621046 8697196 16354765 15668235
MESH:D003110 Colonic Neoplasms Genistein 2.3117182828
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 2.7315531428
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003704 Dementia Polychlorinated Biphenyls 4.8716140633
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.4516647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4517107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5619279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1718230668 15322242 16714409
MESH:D004714 Endometrial Hyperplasia Genistein 4.8316402032
MESH:D016889 Endometrial Neoplasms Estradiol 7.8711473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 7.8711473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4820426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4816530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Cyclosporine 3.0319224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.1810962813 14633661
MESH:D005355 Fibrosis Cyclosporine 9.2112168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2120067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D005909 Glioblastoma Genistein 3.3616598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7210048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1115340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.3015709030
MESH:D019584 Hot Flashes Estradiol 4.0217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3115340226 18606429 8697196 16354765 16959395
MESH:D006973 Hypertension Cyclosporine 5.1410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1418670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 7.8016393666
MESH:D007333 Insulin Resistance Estradiol 7.8016393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Cyclosporine 6.2418776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 6.2415618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.7612371664
MESH:D007680 Kidney Neoplasms Estradiol 7.7615610895
MESH:D007938 Leukemia Genistein 3.1017468513 18980019
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5714716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.5717823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5712878042
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.722125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.7221137059 20195826
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7216984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 15.058603461
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 15.05598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 15.051423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.0512151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 5.0014755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.0018816296 17053015 20464547 20869020 18569708 18520028 20135361 20064080 6695378
MESH:D008175 Lung Neoplasms Methylcholanthrene 5.007750092 21163286 16337739 11893704 9230183 10545420 1399818 16271038 20970405 20512841 15390079 17909032 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0011884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.4411807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.4414578162 12929590
MESH:D020149 Manganese Poisoning Estradiol 4.7519453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D009203 Myocardial Infarction Genistein 2.9217141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.9516810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.9517141266
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2411141357
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4419348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 25.1916427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 25.1911399458 16427766
MESH:D009421 Nervous System Malformations Genistein 25.1916427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 25.1914600291
MESH:D010024 Osteoporosis Genistein 3.3519401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.2716169203
MESH:D010049 Ovarian Diseases bisphenol A 5.2311985600
MESH:D010051 Ovarian Neoplasms Estradiol 5.0519401270
MESH:D010051 Ovarian Neoplasms Genistein 5.0519005980
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.4416702228
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 10.3110548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.3111222880 11118676 11399792 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 11.1320887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 11.1320887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8717292933
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8716740699
MESH:D011471 Prostatic Neoplasms Estradiol 1.8716740699
MESH:D011471 Prostatic Neoplasms Genistein 1.8715256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 1.8715721890
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D011629 Puberty, Precocious bisphenol A 5.0210548101
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7219755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7216192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D019966 Substance-Related Disorders bisphenol A 4.2216045194 16684133
MESH:D013921 Thrombocytopenia marker/mechanism
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013978 Tibial Fractures Estradiol 4.9519048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2317053015
MESH:D014591 Uterine Diseases bisphenol A 5.2714652134
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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