AutismKB 2.0

Annotation Detail for PPFIBP2


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Basic Information Top
Gene Symbol:PPFIBP2 ( Cclp1,DKFZp781K06126,MGC42541 )
Gene Full Name: PTPRF interacting protein, binding protein 2 (liprin beta 2)
Band: 11p15.4
Quick LinksEntrez ID:8495; OMIM: 603142; Uniprot ID:LIPB2_HUMAN; ENSEMBL ID: ENSG00000166387; HGNC ID: 9250
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PPFIBP2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PPFIBP2 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of PPFIBP2 mRNAaffects expression 21346803
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PPFIBP2 mRNAdecreases expression 20064835
D016572 Cyclosporine Cyclosporine results in decreased expression of PPFIBP2 mRNAdecreases expression 20106945
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of PPFIBP2 mRNAaffects cotreatment|decreases expression 17404688
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PPFIBP2 mRNAincreases expression 16954407
D010126 Ozone Ozone results in decreased expression of PPFIBP2 mRNAdecreases expression 12763052
C006253 pirinixic acid pirinixic acid results in increased expression of PPFIBP2 mRNAincreases expression 17426115
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of PPFIBP2 mRNAaffects cotreatment|decreases expression 17404688
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PPFIBP2 mRNAincreases expression 18796159
D014212 Tretinoin Tretinoin results in decreased expression of PPFIBP2 mRNAdecreases expression 16604517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 9.007525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.0011752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.1520127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 7.1511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.1514692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.716695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.4216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4216835633
MESH:D000505 Alopecia Tretinoin 3.7015955085
MESH:D000544 Alzheimer Disease Ozone 2.4615513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.4215885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.4216412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.7515570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.7516292516
MESH:D001249 Asthma Ozone 5.0517854713 16373670
MESH:D001249 Asthma Tretinoin 5.0516456186
MESH:D001471 Barrett Esophagus Tretinoin 4.5316935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.9319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.9312125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.9316206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.5117868700
MESH:D001930 Brain Injuries Progesterone 4.4015845082 15380490 15665606
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3520146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 2.3512948864 14630087 17289903 18497071 17018787 19861407 16675129 17261762
MESH:D001943 Breast Neoplasms Progesterone 2.3516175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3520435547
MESH:D001943 Breast Neoplasms Tretinoin 2.3516873071 16166294 16443354
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7618417511 14754758 18315731 17626835 15516495 16777450 19059883
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7416813970
MESH:D002100 Cachexia Ozone 4.8916183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6216111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3316168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7016705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7016705839
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.7016924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.701917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.6620419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.6616096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218850075 16120746 18670907
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.8114694615
MESH:D002386 Cataract Tretinoin 7.8117460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.586135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.5812371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.5818566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7416129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Cyclosporine 13.8219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.8216105132 11677210 17681005 15861022 16919318 17110522 17333356
MESH:D002779 Cholestasis pirinixic acid 13.8219176532
MESH:D002822 Choriocarcinoma Tretinoin 5.3316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.9015668235 15340226 12621046 8697196 16354765
MESH:D002972 Cleft Palate Tretinoin 5.909407595
MESH:D003092 Colitis Tretinoin 3.8417035595
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.5215095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.5214669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4810048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.489125849 17551590 9211117 16925845 9224671 9142499 8800419 10589399 14991402 9664655
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.3618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.3618551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5119279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.6317187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.2418551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.2421346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 9.2421346803
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.2420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004487 Edema pirinixic acid 6.9012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.9011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.5318230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 12.5318230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.4612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 9.4617692515
MESH:D016889 Endometrial Neoplasms Estradiol 7.6519148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Tretinoin 7.6516569247
MESH:D004715 Endometriosis Progesterone 9.2816134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.2810568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0316530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.1111564622
MESH:D005124 Eye Abnormalities Tretinoin 9.1116938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 13.6519224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.6515345470
MESH:D005234 Fatty Liver pirinixic acid 13.6519236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005355 Fibrosis Cyclosporine 15.5612639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.5620067830
MESH:D005355 Fibrosis Tretinoin 15.5617994277
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D005909 Glioblastoma Tretinoin 3.0717312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3316084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.4120471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.4111294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 11.4114991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly pirinixic acid 8.7316221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.7315340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.2115709030
MESH:D019584 Hot Flashes Estradiol 3.9317088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2215340226 18606429 8697196 16354765 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.3016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7116778211
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006973 Hypertension Cyclosporine 5.0710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0718670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5415869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007249 Inflammation Progesterone 5.1515869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1512200463 12878042
MESH:D007333 Insulin Resistance Estradiol 7.4316393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.4316306350
MESH:D007410 Intestinal Diseases Tretinoin 3.9017994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.3016580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.3015992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Cyclosporine 6.1418776723 8314463 10903974
MESH:D007674 Kidney Diseases Estradiol 6.1415618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 18.5316705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 18.5316705839
MESH:D007680 Kidney Neoplasms Cyclosporine 18.5312371664
MESH:D007680 Kidney Neoplasms Estradiol 18.5315610895
MESH:D007938 Leukemia Tretinoin 2.8217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8116482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0919850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2217506722 17712046 9834237 17301526 17368321 19642359 15748426 17294898 17217047 19035177 12679006 19029980 16140955 16823087 16766008 19225113 16331271 16935935 17339181 17649720 17361223 17107899 19075265 16891316 16788101
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.389224671
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.0214659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 5.0216248980 18397230
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.987678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.9820195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 10.9816377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.9816984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.956135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9512151625
MESH:D008171 Lung Diseases Ozone 3.458266340 19066396
MESH:D055370 Lung Injury Ozone 3.9920417186
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4520464547 17053015 6695378 18520028 18569708 20064080 20135361 20869020 18816296
MESH:D008175 Lung Neoplasms Ozone 3.458597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4511884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.2911807958 11408345 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.2917203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.6619453300
MESH:D008527 Medulloblastoma Tretinoin 2.8217453147
MESH:D008545 Melanoma Tretinoin 1.9516752155
MESH:D008591 Meningomyelocele Tretinoin 4.5616940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D008679 Metaplasia Ozone 5.2810496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1417596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.5316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.5316411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.8718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.877678174 18551238
MESH:D009369 Neoplasms Benzo(a)pyrene 8.4911141357
MESH:D009369 Neoplasms pirinixic acid 8.4917405874
MESH:D009369 Neoplasms Tretinoin 8.4916946489 16594593
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 17.1016427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 17.1014600291
MESH:D009421 Nervous System Malformations Tretinoin 17.109125849
MESH:D009436 Neural Tube Defects Tretinoin 3.129142499
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 15.7712819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 15.7716049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 15.7714694615
MESH:D010051 Ovarian Neoplasms Estradiol 8.0719401270
MESH:D010051 Ovarian Neoplasms Progesterone 8.0717393432 16525653
MESH:D010051 Ovarian Neoplasms Tretinoin 8.0716936753
MESH:D010146 Pain Tretinoin 2.9916870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5015976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D010538 Peritonitis Ozone 4.2716369182
MESH:D011014 Pneumonia Ozone 4.5518007984 18929643 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411222880 11118676 11399792 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0817292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.0816740699
MESH:D011507 Proteinuria Tretinoin 3.7216636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.4715861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D011625 Pterygium Tretinoin 4.9516723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2216283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8918045962
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1118551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.1118551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.6710029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.6716192470
MESH:D012878 Skin Neoplasms Tretinoin 9.6716467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.4315862959 16503802
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.372093021 20155912
MESH:D013274 Stomach Neoplasms Tretinoin 2.3717261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1117045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.8619048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.8916051514
MESH:D014376 Tuberculosis Tretinoin 3.2916040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.5016049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.5016049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.5017053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.5110091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.5110091137
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7816129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.7816752155
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6515869587 14671159
MESH:D014820 Vitiligo Tretinoin 4.1816761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D009396 Wilms Tumor Tretinoin 4.0716287080
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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