AutismKB 2.0

Annotation Detail for CGNL1


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Basic Information Top
Gene Symbol:CGNL1 ( FLJ14957,JACOP,KIAA1749,MGC138254 )
Gene Full Name: cingulin-like 1
Band: 15q21.3
Quick LinksEntrez ID:84952; OMIM: 607856; Uniprot ID:CGNL1_HUMAN; ENSEMBL ID: ENSG00000128849; HGNC ID: 25931
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of CGNL1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of CGNL1 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CGNL1 mRNAdecreases expression 20106945
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of CGNL1 mRNAincreases expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of CGNL1 mRNAdecreases expression 20106945
D002117 Calcitriol Calcitriol results in decreased expression of CGNL1 mRNAdecreases expression 16002434
C006253 pirinixic acid pirinixic acid results in increased expression of CGNL1 mRNAincreases expression 18301758
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CGNL1 mRNAdecreases expression 20106945
D014635 Valproic Acid Valproic Acid results in increased expression of CGNL1 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.2811752688 15322242 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.288875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1319490988
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.8716835633
MESH:D000550 Amblyopia Valproic Acid 5.5517688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.7417497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8617157402 18940202 17507914 18396377 20603192 17688650 15238991 19460635 18558336 19232924 16609825 18316065 18985861 18177632 18775368
MESH:D001714 Bipolar Disorder Valproic Acid 3.1720046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.4619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.4315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.438888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8520146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 1.8511237771
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8520435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0418705752 16227642 16192424 15673190 16050911 15700767 16124888 15721981 16011737 3786805 16097048 10355542
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.703084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.7021507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7018788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8620419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.8611237771
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6612371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7720734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis Cyclosporine 8.2619486331
MESH:D002779 Cholestasis pirinixic acid 8.2619176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1815340226 8697196 15668235 16354765 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5210048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.5217688650 8888407 16575769
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.4016393943 14725611 19164858 10915739 17562736 12958197 12594235 18071297 16177239 19739265 16227642 17522070 16081117 11287661 19370779 19416960 16485898 11834606 16109766 11421492 15968718 11529661 19085960 12540782 15619225 10663392 19923254 12153990 19420014 11461765 2444490 12705907 10774834 17906064 18713872 16781746 11743745 14986274 11739529 14550746 12392966
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.4016177239 6623471 9327722 7120509 10915739 6884620 16227642 15027814 7440962 10092053 15968718 11566570 4309450 19336974 15998439 7179309 19085960 2869522 17522070 3732212 21278145 3786805
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.4020420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.401733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004421 Dystonia Valproic Acid 4.271851702
MESH:D004487 Edema pirinixic acid 7.2312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2218230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.1715138306
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.4117275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.233922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0318234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.776426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.353659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0516530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.5512795759 17595544 15959796 16239168 12631006 61145 16045604 19224547
MESH:D005234 Fatty Liver Cyclosporine 20.5519224547
MESH:D005234 Fatty Liver pirinixic acid 20.5520131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 20.5519224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005315 Fetal Diseases Valproic Acid 5.2016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.3718558336 8888407
MESH:D005355 Fibrosis Carbon Tetrachloride 16.2918705752
MESH:D005355 Fibrosis Cyclosporine 16.2912639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.2920067830
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7710048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8319900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 9.1419772884 19176532 16221962 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.1416120746 15340226 12621046
MESH:D006849 Hydrocephalus Valproic Acid 5.1517688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3615340226 8697196 18606429 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8216899240
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006973 Hypertension Cyclosporine 5.1710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1718670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3515338365
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9512200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1615629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.168314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9012371664
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1817596541 16294345
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9116239168 17334410 16221502 17174718 11408273 17157831 16943688 21278145 11903743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5012389079 11481614 17698563 16015684 15338365 18705752 18412020 17823541 17805973 12609069 18054572 12666154 16638106 15057751 17922224 17944888 15925388 20821823 14620537 18317297 18210741 14716496 18006644 14724832 16248980 14748882 18472094 15650968 18395914 18395095 15931870 18277467 12649538 18481824 17481882 15893842 12546737 18472332 15730626 16116963 17869086 18166357 15673190 17565644 16136751 17640975 15370692 18420326 14512876 12958196 17557913 18205269 12445418 15818738 12632514 15876570 12898905 17714472 18279442 18187930 16097048 16027843 17631135 12741479 17761835 17900296 12445421 15123356 12632512 12586293 18376398 17976157 14716833 17525996 18429990 15996030 15052691 18263696 17721639 16011737 18339082 18156304 15959796 17766677 15362042 17708605 18418968 10355542 16192424 18251166 13678700 12667390 16033810
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5012878042
MESH:D008107 Liver Diseases Acetaminophen 4.0512969438 11587558 19784758 12587719 19460945 16610002 19014921 16611625
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0516246199 16964402 17285989 15830285 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.0617185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.0616899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.9715890375 9163691 18177683 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.9721137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.9719294768
MESH:D008113 Liver Neoplasms pirinixic acid 14.9720007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.9716984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.528603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.5215583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.5212151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5817228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4714755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4720869020 20135361 18569708 20064080 18816296 17053015 20464547 6695378 18520028
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4711884234 19555203
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D008881 Migraine Disorders Valproic Acid 3.3318803445 18765137
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.238888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2617596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1311141357
MESH:D009369 Neoplasms pirinixic acid 5.1317405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4718481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.258888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.4311118676 11896295 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.4320603192
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.0615572423
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2317292933
MESH:D011471 Prostatic Neoplasms Calcitriol 3.2316289102 12479363 15754350 16644109 18247401
MESH:D019310 Pseudolymphoma Valproic Acid 4.8611422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4019155313
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures Valproic Acid 2.8714763951 1511512 16876388 17978042 15475178 3137016 11044598 11738929
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7610029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7616192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8612833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D014178 Translocation, Genetic Valproic Acid 5.5517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.813119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2417053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.908888407
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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