AutismKB 2.0

Annotation Detail for DISP1


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Basic Information Top
Gene Symbol:DISP1 ( DISPA,DKFZp434I0428,FLJ43740,MGC104180,MGC13130,MGC16796 )
Gene Full Name: dispatched homolog 1 (Drosophila)
Band: 1q41
Quick LinksEntrez ID:84976; OMIM: 607502; Uniprot ID:DISP1_HUMAN; ENSEMBL ID: ENSG00000154309; HGNC ID: 19711
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
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Pathway IDPathway Name
200144Signaling events mediated by the Hedgehog family
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of DISP1 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of DISP1 mRNAaffects expression 21346803
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of DISP1 geneincreases mutagenesis 16724327
15755804
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 4.697525203
MESH:D000236 Adenoma Ethylnitrosourea 3.946695378
MESH:D001927 Brain Diseases Ethylnitrosourea 5.3314991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.7416357521 16651633 15144691 18412241 16436596
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 1.7916705839
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.8614694615
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 8.006135515
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 8.0016003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.8517160924
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.5815095906
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.6718551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.4418551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 4.4421346803
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.8518357618
MESH:D005909 Glioblastoma Ethylnitrosourea 4.1016436596
MESH:D005910 Glioma Ethylnitrosourea 3.6316651633 16357521 18412241
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 9.0316705839
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 9.0317379185
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.287678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.792876784 2876786 6135515
MESH:D008175 Lung Neoplasms Ethylnitrosourea 2.6316019985 16271038 17703301 6695378
MESH:D008223 Lymphoma Ethylnitrosourea 4.2515790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.7015375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.7718041768 10838139 10767621
MESH:D008579 Meningioma Ethylnitrosourea 6.8517943659
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.6018551238 7678174
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 5.0516707424
MESH:D009442 Neurilemmoma Ethylnitrosourea 6.1616003739 17160924 16651423
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 10.6616049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 10.6614694615
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.8517160924
MESH:D012640 Seizures 2,6-dinitrotoluene 2.8218551238
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.9015790496
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.4216049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 5.0610091137
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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