AutismKB 2.0

Annotation Detail for ARHGAP19


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Basic Information Top
Gene Symbol:ARHGAP19 ( DKFZp313K217,MGC138804,MGC138805,MGC14258 )
Gene Full Name: Rho GTPase activating protein 19
Band: 10q24.1
Quick LinksEntrez ID:84986; OMIM: 611587; Uniprot ID:RHG19_HUMAN; ENSEMBL ID: ENSG00000213390; HGNC ID: 23724
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Signaling by Rho GTPases
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of ARHGAP19 mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ARHGAP19 mRNA]decreases reaction|increases expression 17942915
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ARHGAP19 mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.7315322242 14514962 11752688
MESH:D000236 Adenoma Diethylnitrosamine 3.106695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 13.2318056438 17620307 16434500 19052882 17162532 19061943
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 13.2316835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.4511748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.5912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.8615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0515746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9317474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9320435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 1.8819052882 20007298 20512989 19822196 18971187 16540662 16569478 20935162 19208518 16830150 20727157 16698587 16502159 3581430 16328049 19335982 19383236 21159647 16681979 18978308 18788625 16779866 20514400 17428255 18210153 17978847 18691550 19701751 17162532 19539802 17055752 19394651 10737359 18393292 20101231 18506893 18056438 16807293 16935385 17138121 18494052 17173139 19418558 11831363 20214788 20084675 3084413 18785209 10672840 19519916 18665156 16288022 16878318 20524982 19107877 17761372 19919837 19171122 20432363
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.6018670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.1817174075 7505956 21159647 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 10.9219052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 10.9216835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2616354765 8697196 12621046 15668235 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.5317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 20055451 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.5220387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.5217107852
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 4.0919107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.0920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.1211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.9211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.9716714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.539294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 6.1916302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3811564622
MESH:D005234 Fatty Liver Diethylnitrosamine 3.7321071580 20387270
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.2211858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.7120067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.6610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5510048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.8911000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.6512621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 5.128697196 16959395 15340226 18606429 16354765
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0418850075 18670907
MESH:D007249 Inflammation Diethylnitrosamine 5.6318785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.6312200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.8916580747
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 3.0518522880 18407596 20032147 18665156 19638242
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1817034775
MESH:D008113 Liver Neoplasms Diethylnitrosamine 4.8920405173 19256749 21278145 19255062 20452335 19996281 19690152 20583210 12112319 16942905 20137499 2862719 19426721 21047994 10737359 19427195 19638242 19073162 19812893 21167192 19499222 21071580 12771043 19833225 20492335 19642983 19850985 9163691 18754104 19254457 19551842 20501860 20101389 18648771 2422723 15885732 18644402 19294768 19090486 18978307 15175105 20118626 20434301 18977376
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.8916984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.7119519916 19009564 19126423 2563599 18282651 17854601 18093689 16267830 3124819 21159647 9362446 18775883 16842330 17174075 18308698 19539802 18544905 19004024 17942915 18079962 18253720 18164116
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.7112151625
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.3620970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3611884234 19555203
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.4312213967
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.729029167 3581430
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.8914600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.7820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 6.1920387270
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5516540662
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 5.3212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.2318163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 4.022563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 4.0811222880 11399792 11118676 11896295
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.5118990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2316192470
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.9712697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.367505956
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.6612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 5.3215886252
Pathway ID Pathway Name
REACT:11044 Signaling by Rho GTPases
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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