AutismKB 2.0

Annotation Detail for TMEM141


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Basic Information Top
Gene Symbol:TMEM141 ( MGC14141,RP11-216L13.7 )
Gene Full Name: transmembrane protein 141
Band: 9q34.3
Quick LinksEntrez ID:85014; OMIM: NA; Uniprot ID:TM141_HUMAN; ENSEMBL ID: ENSG00000213213; HGNC ID: 28211
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of TMEM141 mRNAdecreases expression 20106945
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of TMEM141 mRNAdecreases expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of TMEM141 mRNAdecreases expression 20106945
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TMEM141 mRNAaffects binding|decreases expression|increases activity 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.5818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0620127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.866695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.1116434500
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.6419183758
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5719483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9917474063 20146248
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.3410355542 16124888 3786805 18705752 16227642 15700767 16192424 15721981 15673190 16097048 16050911 16011737
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8618788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1320419170
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7912371664
MESH:D002779 Cholestasis Cyclosporine 8.7419486331
MESH:D002779 Cholestasis pirinixic acid 8.7419176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5718249437
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.123732212 19085960 4309450 7179309 11566570 2869522 7120509 15027814 15968718 16177239 17522070 21278145 3786805 7440962 6623471 10092053 15998439 16227642 19336974 10915739 6884620 9327722
MESH:D004487 Edema pirinixic acid 2.9012083418
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0816530937
MESH:D005234 Fatty Liver Carbon Tetrachloride 15.6461145 17595544 16045604 16239168 12795759 15959796 19224547 12631006
MESH:D005234 Fatty Liver Cyclosporine 15.6419224547
MESH:D005234 Fatty Liver pirinixic acid 15.6420131406 19236843
MESH:D005355 Fibrosis Carbon Tetrachloride 10.6018705752
MESH:D005355 Fibrosis Cyclosporine 10.6012639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.858708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8320471113
MESH:D006333 Heart Failure pirinixic acid 2.7620558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.0515720958
MESH:D006505 Hepatitis Carbon Tetrachloride 4.1019110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 3.5519772884 18467677 19176532 16221962
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.1616899240
MESH:D006943 Hyperglycemia pirinixic acid 3.5820558911
MESH:D006973 Hypertension Cyclosporine 2.2110903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.6515338365
MESH:D007333 Insulin Resistance pirinixic acid 2.8716306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.1615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.548314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0812371664
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 3.0016221502 11903743 16239168 16943688 21278145 11408273 17174718 17334410 17157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.4118187930 17761835 17869086 18210741 18472094 15876570 14716496 18376398 15362042 17708605 15057751 18251166 15123356 15673190 17823541 15818738 12666154 15338365 17922224 17640975 17944888 17525996 18166357 18412020 15925388 12898905 16638106 18395914 15931870 12667390 18481824 18418968 17766677 18156304 16097048 12958196 17976157 12546737 16015684 17714472 18420326 17805973 18205269 12632514 15052691 13678700 12609069 16248980 17900296 12445421 14716833 15730626 18472332 17557913 18263696 17565644 18006644 16027843 12389079 17698563 16192424 12632512 18279442 17631135 17721639 15996030 16136751 16116963 18317297 10355542 14724832 18054572 18395095 14512876 15370692 12741479 12445418 12586293 15893842 14620537 15650968 17481882 11481614 18705752 20821823 12649538 14748882 16033810 18277467 15959796 16011737 18429990 18339082
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4115474484
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1516246199 15830285 17285989 16964402 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.7315123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.0816899240 14706259
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 8.1021137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 8.1019294768
MESH:D008113 Liver Neoplasms pirinixic acid 8.1016377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.8415583823 12014681
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5720064080 17053015 6695378 20464547 20135361 18520028 18816296 18569708 20869020
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.5116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5016381670
MESH:D009135 Muscular Diseases pirinixic acid 4.0716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2516411023
MESH:D009369 Neoplasms Benzo(a)pyrene 5.3911141357
MESH:D009369 Neoplasms pirinixic acid 5.3917405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.1617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6519348381 18481113
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D011230 Precancerous Conditions Cyclosporine 3.5912371664
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9117292933
MESH:D011565 Psoriasis Cyclosporine 2.3316882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.5519058328
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5210029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.3017053015
MESH:D014605 Uveitis Cyclosporine 4.711336536
MESH:D014985 Xerophthalmia Cyclosporine 5.1617120751
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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