AutismKB 2.0

Annotation Detail for NIPSNAP1


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Basic Information Top
Gene Symbol:NIPSNAP1 ( - )
Gene Full Name: nipsnap homolog 1 (C. elegans)
Band: 22q12.2
Quick LinksEntrez ID:8508; OMIM: 603249; Uniprot ID:NIPS1_HUMAN; ENSEMBL ID: ENSG00000184117; HGNC ID: 7827
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NIPSNAP1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of NIPSNAP1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of NIPSNAP1 proteinaffects expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of NIPSNAP1 mRNAdecreases expression 20106945
C014347 decitabine decitabine affects the expression of NIPSNAP1 mRNAaffects expression 17145863
C014347 decitabine decitabine results in increased expression of NIPSNAP1 mRNAincreases expression 17908484
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of NIPSNAP1 mRNAdecreases expression 17557909
C066340 tolcapone tolcapone binds to NIPSNAP1 proteinaffects binding 19783845
D014303 Trinitrotoluene Trinitrotoluene affects the expression of NIPSNAP1 mRNAaffects expression 21346803
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 4.527525203
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D017109 Akathisia, Drug-Induced tolcapone 6.6711080934
MESH:D000544 Alzheimer Disease tolcapone 3.3220150427
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms decitabine 2.5518320071 19208741
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.713084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.7121507988 12907637 12619106
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6519215824
MESH:D002386 Cataract Acetaminophen 7.9410977129
MESH:D002386 Cataract Trinitrotoluene 7.9414694615 15817613
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6812371664
MESH:D002779 Cholestasis Cyclosporine 8.3719486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.3715861022 11677210 17110522 16919318 17333356 17681005 16105132
MESH:D003110 Colonic Neoplasms decitabine 2.3717616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Trinitrotoluene 4.6115095906
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.2718551238
MESH:D003490 Cyanosis Trinitrotoluene 12.2718551238
MESH:D003866 Depressive Disorder tolcapone 4.4711224284 7768276
MESH:D003865 Depressive Disorder, Major tolcapone 5.1210440460
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.5821346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.5819420014 16781746 16227642 12705907 11743745 11421492 14986274 10915739 18713872 14725611 19370779 17906064 16485898 10663392 15619225 15968718 16177239 17522070 12153990 11461765 16081117 18071297 16393943 19416960 11834606 11287661 19085960 11529661 12392966 19739265 11739529 12958197 19923254 10774834 14550746 12594235 19164858 16109766 2444490 12540782 17562736
MESH:D056486 Drug-Induced Liver Injury tolcapone 9.5816604736 19783845
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 9.5821346803 18551238
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004409 Dyskinesia, Drug-Induced tolcapone 5.7711455177
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4712538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.4919294695
MESH:D054908 Extensively Drug-Resistant Tuberculosis tolcapone 6.3219578428
MESH:D005234 Fatty Liver Cyclosporine 8.4019224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.4015345470
MESH:D005355 Fibrosis Cyclosporine 3.4512168785 12639820
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006258 Head and Neck Neoplasms decitabine 3.6419215824
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006529 Hepatomegaly Trinitrotoluene 4.5415817613
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male decitabine 12.2317581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 12.2317937319
MESH:D007248 Infertility, Male Trinitrotoluene 12.2312150543
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Acetaminophen 6.2212587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.228314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.9516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.9512371664
MESH:D007938 Leukemia decitabine 3.1818980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 4.2417236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4119010910 17679729 18460780 19387464 18206229 18704418
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.8418055864
MESH:D008107 Liver Diseases Acetaminophen 1.6719460945 16610002 19784758 12587719 19014921 16611625 12969438 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 2.429163691 18177683 2125692 15890375
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.888603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 1.8714755239
MESH:D008223 Lymphoma decitabine 3.5819470736
MESH:D008545 Melanoma decitabine 2.2716505122 17785578
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009101 Multiple Myeloma decitabine 3.5118172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.5119010910 16882708 18608210 19157545
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.8318551238
MESH:D009336 Necrosis Trinitrotoluene 11.8318551238
MESH:D009369 Neoplasms decitabine 2.8119116145 17925555 19470736
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.9912819281 16049721
MESH:D009784 Occupational Diseases Trinitrotoluene 9.9912819281 14694615 17852074
MESH:D010051 Ovarian Neoplasms decitabine 2.7119259094 19331143
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms decitabine 2.8419294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010300 Parkinson Disease tolcapone 3.679754991 9708959 20216409 9305320 17089403 9591521 9333106 1977408 10651109 8635184 11793426 16758261 19783845 19578428 8739811 11586115 18328768 11432539 11746615 7566641 20334432
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D055728 Primary Myelofibrosis decitabine 5.0317616702
MESH:D011537 Pruritus Ethinyl Estradiol 3.6515861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D012208 Rhabdomyosarcoma decitabine 4.6619155313
MESH:D012640 Seizures 2,4-dinitrotoluene 6.7318551238
MESH:D012640 Seizures Trinitrotoluene 6.7318551238
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D013163 Splenomegaly Trinitrotoluene 5.5115817613
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013964 Thyroid Neoplasms decitabine 3.5117967635
MESH:D018088 Tuberculosis, Multidrug-Resistant tolcapone 6.3219578428
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.4416049721
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.4417616700 19087683
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6510091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D014604 Uveal Neoplasms decitabine 5.2917785578
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7815869587 14671159
MESH:D014820 Vitiligo tolcapone 5.4710573327
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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