AutismKB 2.0

Annotation Detail for NDST2


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Basic Information Top
Gene Symbol:NDST2 ( HSST2,MGC129697,MGC129705,NST2 )
Gene Full Name: N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
Band: 10q22.2
Quick LinksEntrez ID:8509; OMIM: 603268; Uniprot ID:NDST2_HUMAN; ENSEMBL ID: ENSG00000166507; HGNC ID: 7681
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6564heparan sulfate biosynthesis
PWY-6558heparan sulfate biosynthesis (late stages)
Pathway IDPathway Name
hsa00534Glycosaminoglycan biosynthesis - heparan sulfate
hsa01100Metabolic pathways
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NDST2 mRNAaffects expression 21346803
D001241 Aspirin Aspirin results in increased expression of NDST2 mRNAincreases expression 11906190
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NDST2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NDST2 mRNAaffects cotreatment|increases expression 17942748
C029424 hydrazine hydrazine results in decreased expression of NDST2 mRNAdecreases expression 15282401
D013467 Sulindac Sulindac results in decreased expression of NDST2 mRNAdecreases expression 11906190
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NDST2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NDST2 mRNAincreases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 6.0214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3114514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D058186 Acute Kidney Injury Sulindac 4.647897758
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.8114692618
MESH:D000230 Adenocarcinoma Sulindac 4.8111910360
MESH:D000236 Adenoma Sulindac 3.9410223192
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.9015623613 11874996 17611924 11535846 19003578 12394442 16460482
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8415885639
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.9720485159 12372130
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001913 Bowen's Disease Sulindac 5.8711207687
MESH:D001932 Brain Neoplasms Aspirin 4.7215481559
MESH:D001943 Breast Neoplasms Aspirin 2.0815161893
MESH:D001943 Breast Neoplasms Sulindac 2.0816642371
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 1.7816705839
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218850075 18670907 16120746
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1011677210 17681005 17333356 15861022 17110522 16919318 16105132
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2116354765 12621046 15340226 8697196 15668235
MESH:D003110 Colonic Neoplasms Aspirin 4.5212411196
MESH:D003110 Colonic Neoplasms Sulindac 4.5212458338 12902858
MESH:D015179 Colorectal Neoplasms Aspirin 3.1817047198
MESH:D015179 Colorectal Neoplasms Sulindac 3.1818059344 11197048 10666051 11076880
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.4318551238
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003930 Diabetic Retinopathy Sulindac 5.5617621415 12861449
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.9518551238 21346803
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004487 Edema Aspirin 8.1517259670
MESH:D004487 Edema Tetrachlorodibenzodioxin 8.1512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4215322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5712538720
MESH:D004715 Endometriosis Sulindac 10.2215652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 10.229294722 10568697
MESH:D004938 Esophageal Neoplasms Sulindac 3.1912235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.1415345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D018221 Fibromatosis, Abdominal Sulindac 5.9414745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 5.5919069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3620067830
MESH:D005764 Gastroesophageal Reflux Sulindac 5.3911910360
MESH:D005909 Glioblastoma Aspirin 4.1412870263
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006261 Headache Aspirin 5.4815240983
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4710048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3116120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.578697196 18606429 15340226 16354765 16959395
MESH:D012001 Hyperacusis Aspirin 6.2815240983
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6817937319
MESH:D007249 Inflammation Sulindac 5.723291741
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.7212200463 12878042
MESH:D007414 Intestinal Neoplasms Sulindac 4.9410223192 12628509 12584176 12351151 12663524 10213222
MESH:D007417 Intestinal Polyps Sulindac 5.3411245490 12394442
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.2416705839
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.4012468960
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008107 Liver Diseases Sulindac 3.0914986274 16867024
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2812151625
MESH:D008175 Lung Neoplasms Sulindac 2.6715713900 19359593
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.6719555203 11884234
MESH:D008545 Melanoma Sulindac 2.8616642371
MESH:D008881 Migraine Disorders Aspirin 4.2815240983
MESH:D009203 Myocardial Infarction Aspirin 3.6612692751
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009325 Nausea Aspirin 5.7315240983
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.3218551238
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D019636 Neurodegenerative Diseases Sulindac 4.5416850258 17266991
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.7316049721 12819281
MESH:D010003 Osteoarthritis Aspirin 4.237009135
MESH:D010146 Pain Aspirin 8.356363464 6995502
MESH:D010146 Pain Sulindac 8.353291741
MESH:D010190 Pancreatic Neoplasms Sulindac 3.4416820089 11504793
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 6.0011156591
MESH:D020795 Photophobia Aspirin 6.2815240983
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511222880 11896295 11399792 11118676
MESH:D011537 Pruritus Ethinyl Estradiol 3.7716919318 15861022
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012220 Rhinitis Aspirin 4.6812372130
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7318551238
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 5.6812269725
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.4616709447
MESH:D020521 Stroke Aspirin 4.6316403987
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Aspirin 10.1617672075
MESH:D013927 Thrombosis Ethinyl Estradiol 10.1615669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3816049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7810091137
MESH:D014581 Urticaria Aspirin 4.7920485159 10982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 10.9714692618
MESH:D014594 Uterine Neoplasms Sulindac 10.9718645019
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8714671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
Pathway ID Pathway Name
KEGG:00534 Glycosaminoglycan biosynthesis - heparan sulfate
KEGG:01100 Metabolic pathways
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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