AutismKB 2.0

Annotation Detail for ITGA8


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ITGA8 ( - )
Gene Full Name: integrin, alpha 8
Band: 10p13
Quick LinksEntrez ID:8516; OMIM: 604063; Uniprot ID:ITA8_HUMAN; ENSEMBL ID: ENSG00000077943; HGNC ID: 6144
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
hsa04810Regulation of actin cytoskeleton
hsa04514Cell adhesion molecules (CAMs)
hsa04512ECM-receptor interaction
hsa04510Focal adhesion
Pathway IDPathway Name
Integrin cell surface interactions
No data
Pathway IDPathway Name
P00034Integrin signalling pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
Parkinson's disease
NEUROLOGICAL
quantitative traits
Desease Name
Parkinson's disease
Quantitative traits
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of ITGA8 mRNAincreases expression 20406850
C029955 2-nitrotoluene 2-nitrotoluene results in decreased expression of ITGA8 mRNAdecreases expression 16460773
D000082 Acetaminophen Acetaminophen affects the expression of ITGA8 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ITGA8 mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in decreased expression of ITGA8 mRNAdecreases expression 19654921
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ITGA8 mRNAaffects cotreatment|increases expression 18164116
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ITGA8 mRNAincreases expression 20382639
C099813 bromochloroacetic acid bromochloroacetic acid results in decreased expression of ITGA8 mRNAdecreases expression 16460773
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of ITGA8 mRNAaffects expression 17484886
D003345 Corticosterone Corticosterone results in increased expression of ITGA8 mRNAincreases expression 15755911
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ITGA8 mRNAaffects cotreatment|increases expression 18164116
D010672 Phenytoin Phenytoin results in increased expression of ITGA8 mRNAincreases expression 14741686
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenytoin 4.643425630 9118846 10563481 6195326 8986270 9677735
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000236 Adenoma beta-Naphthoflavone 7.0819389873
MESH:D000236 Adenoma Diethylnitrosamine 7.0810737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.0519061943 19052882 17620307 16434500 17162532 18056438
MESH:D018246 Adrenocortical Adenoma Arsenic 5.3917306315
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D020261 Arsenic Poisoning Arsenic 2.8912569548 16835338 16251483 18414634
MESH:D050197 Atherosclerosis Arsenic 7.3412928151 19371607
MESH:D050197 Atherosclerosis Phenytoin 7.3415136057
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2217474063
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9216050911 16227642 16097048 15673190 18705752 15721981 16124888 15700767 16192424 10355542 3786805 16011737
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6515504454 17687452
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.0516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.053084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 9.0517306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 9.0518788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 9.0519107877 19701751 16681979 17761372 19519916 16569478 19418558 16878318 20512989 19052882 20935162 16935385 17428255 18210153 18056438 3084413 16807293 17055752 18971187 19171122 17162532 20214788 19383236 17138121 11831363 10672840 20007298 19539802 20101231 17978847 18691550 18393292 19335982 16288022 16779866 17173139 3581430 19919837 20432363 19208518 18785209 18506893 18665156 18788625 21159647 16328049 16830150 20514400 18978308 20727157 10737359 16502159 18494052 16540662 19394651 19822196 20084675 16698587 20524982
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7215504454 18922899 17687452
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.1818640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.5215738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.4118022660 16973168
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002430 Cecal Neoplasms 2-nitrotoluene 5.7914688030
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.626135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.6220889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.6217174075 7505956 21159647 2727394
MESH:D002493 Central Nervous System Diseases Phenytoin 5.444080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7819052882
OMIM:601042 CHOREOATHETOSIS/SPASTICITY, EPISODIC Phenytoin 6.0211748493
MESH:D002971 Cleft Lip Phenytoin 4.202227380
MESH:D002972 Cleft Palate Phenytoin 3.7810789828 6862529 6856622 3877104 2227380 1687470
MESH:D003103 Coloboma Phenytoin 5.269212184
MESH:D000013 Congenital Abnormalities Phenytoin 4.8010627286
MESH:D019465 Craniofacial Abnormalities Phenytoin 2.908986270 9212184 19952982
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1618551238
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2120387270
OMIM:607208 DRAVET SYNDROME Phenytoin 5.5311748493
MESH:D003875 Drug Eruptions Phenytoin 5.6415024534
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.2221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.2212392966 16227642 19923254 10915739 2444490 14986274 16485898 14725611 16109766 12705907 15619225 11287661 17562736 18071297 12594235 19739265 10774834 11834606 12153990 17522070 19164858 19416960 18713872 12540782 16393943 16177239 19370779 15968718 19420014 11421492 10663392 19085960 14550746 17906064 11739529 16781746 11743745 16081117 11529661 12958197 11461765
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.223732212 19085960 19336974 10915739 7120509 17522070 6884620 9327722 10092053 15968718 2869522 16227642 15998439 4309450 11566570 16177239 6623471 3786805 15027814 7440962 7179309 21278145
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.2219107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Phenytoin 4.8017654737
MESH:D004816 Epidermal Necrolysis, Toxic Phenytoin 5.3220235791
MESH:D004820 Epidermolysis Bullosa Phenytoin 6.411399206 6251365
MESH:D004828 Epilepsies, Partial Phenytoin 5.0911558140 17116037
MESH:D004827 Epilepsy Phenytoin 3.9920417680 11434505 821787
MESH:D017029 Epilepsy, Complex Partial Phenytoin 5.447750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenytoin 5.223659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2916302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1020426865
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.2061145 12795759 19224547 15959796 16045604 12631006 16239168 17595544
MESH:D005234 Fatty Liver Diethylnitrosamine 8.2021071580 20387270
MESH:D005313 Fetal Death Phenytoin 5.2310627286
MESH:D005355 Fibrosis Carbon Tetrachloride 3.5918705752
MESH:D005534 Foot Diseases Arsenic 5.736392382
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005885 Gingival Hyperplasia Phenytoin 5.829029455
MESH:D019214 Gingival Overgrowth Phenytoin 6.4114659971 16390469
MESH:D006394 Hemangiosarcoma 2-nitrotoluene 5.1913678655
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7219900420 19110552
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6916899240
MESH:D020138 Hyperhomocysteinemia Phenytoin 4.7710459572
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5617050553
MESH:D006973 Hypertension Arsenic 2.9016076760 11953799 9931084
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2315338365
MESH:D006987 Hypesthesia Arsenic 5.7316093927
MESH:D007249 Inflammation Diethylnitrosamine 2.4318785209
MESH:D007642 Keratosis Arsenic 5.1416930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 2.2612587719 15629191
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.0716705839
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.6217339181
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.8016943688 17174718 11408273 16239168 16221502 17157831 21278145 11903743 17334410
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.8020032147 18407596 18665156 19638242 18522880
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7516248980 17976157 14716496 15052691 12649538 12609069 18395914 11481614 17698563 17900296 18481824 15996030 15931870 18420326 17708605 17766677 12445418 18187930 18166357 12445421 14620537 15123356 15370692 14716833 17823541 16097048 12389079 20821823 16638106 15893842 17922224 16033810 18412020 18156304 16015684 17525996 12632514 12586293 15925388 17640975 17805973 15362042 17481882 12958196 17761835 14724832 18006644 18418968 17869086 17714472 18472332 10355542 12666154 18251166 15730626 18705752 15338365 12741479 18054572 16027843 16136751 18317297 14748882 12667390 15673190 18263696 18472094 18395095 14512876 18429990 18277467 12632512 18210741 17565644 17557913 16116963 15818738 15959796 12546737 16192424 12898905 15650968 18205269 16011737 18279442 13678700 17721639 15876570 17631135 18376398 18339082 17944888 15057751
MESH:D008107 Liver Diseases Acetaminophen 12.8412587719 19784758 16611625 19460945 11587558 19014921 16610002 12969438
MESH:D008107 Liver Diseases Arsenic 12.8411134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 12.8416246199 15720792 16964402 15830285 17285989
MESH:D008107 Liver Diseases Diethylnitrosamine 12.8417034775
MESH:D008107 Liver Diseases Phenytoin 12.8414986274
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3015123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.7616871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.7616899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.687678174
MESH:D008113 Liver Neoplasms Arsenic 14.6816368122
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 14.6819389873 21295105
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.6819294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.6819996281 19254457 20434301 18754104 20492335 21278145 2422723 19499222 16942905 15175105 19073162 19638242 20583210 18644402 20501860 19812893 19294768 18648771 19255062 19426721 15885732 19690152 19427195 20452335 18978307 18977376 9163691 12112319 21167192 20101389 19256749 12771043 10737359 20137499 19833225 21047994 20118626 2862719 19551842 19642983 21071580 20405173 19850985 19090486
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.716135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 14.7118164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 14.7112014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.7118282651 18079962 17942915 16267830 9362446 19539802 18093689 18544905 19004024 3124819 18253720 18775883 17854601 19009564 2563599 16842330 18164116 19519916 21159647 17174075 18308698 19126423
MESH:D008175 Lung Neoplasms Arsenic 2.6419168569 17306315 17976673
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.6420970405 21163286 6695378 20512841
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 3.6912807724
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008607 Mental Retardation Phenytoin 3.709212184
MESH:D019042 Muscle Neoplasms 2-nitrotoluene 6.8613678655
MESH:D017202 Myocardial Ischemia Arsenic 4.0715371236
MESH:D020191 Myoclonic Epilepsies, Progressive Phenytoin 5.6817484760
MESH:D009224 Myotonia Congenita Phenytoin 5.561896199
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.0118551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.609029167 3581430
MESH:D009436 Neural Tube Defects Arsenic 8.0516620997
MESH:D009436 Neural Tube Defects Phenytoin 8.059118846
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.4918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.4920387270
MESH:D020078 Neurogenic Inflammation Arsenic 4.4917056641
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2920387270
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5316049721
MESH:D010018 Osteomalacia Phenytoin 5.5617016548
MESH:D010051 Ovarian Neoplasms marker/mechanism 17303177
MESH:D010051 Ovarian Neoplasms Arsenic 2.7717306315
MESH:D010146 Pain Acetaminophen 7.2916870215
MESH:D010146 Pain Phenytoin 7.2915215642
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4516540662
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.3016093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.1415371236 6392382 16905509
MESH:D017689 Polydactyly Phenytoin 5.149212184
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.652563599
MESH:D011471 Prostatic Neoplasms Arsenic 3.5916140617
MESH:D011507 Proteinuria Arsenic 4.1221343184
MESH:D019310 Pseudolymphoma Phenytoin 5.728603615 1419762 12752131
MESH:D012640 Seizures 2,6-dinitrotoluene 6.5618551238
MESH:D012640 Seizures Phenytoin 6.5619919933 10029267 3691417 15946322 16876388 11044598 9844417 3137016
MESH:D012871 Skin Diseases Arsenic 2.7719834688 15952646 17938729 16353154 16702368 17453740 16759981 17050553 17548696 18709164 6392382
MESH:D012878 Skin Neoplasms Arsenic 3.0517976673 17050553 17029826 15504454 19538983 16251483
MESH:D013262 Stevens-Johnson Syndrome Phenytoin 5.2920235791
MESH:D013274 Stomach Neoplasms marker/mechanism 17786296
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.077505956
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.3416049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.3417976673 18640142 11144890 19429237 19322015 17306315 15987713
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4710091137
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014652 Vascular Diseases Arsenic 4.8917056641
Pathway ID Pathway Name
KEGG:05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
KEGG:04514 Cell adhesion molecules (CAMs)
KEGG:05414 Dilated cardiomyopathy
KEGG:04512 ECM-receptor interaction
KEGG:04510 Focal adhesion
KEGG:05410 Hypertrophic cardiomyopathy (HCM)
REACT:13552 Integrin cell surface interactions
KEGG:04810 Regulation of actin cytoskeleton
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved