AutismKB 2.0

Annotation Detail for IFITM1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:IFITM1 ( 9-27,CD225,IFI17,LEU13 )
Gene Full Name: interferon induced transmembrane protein 1 (9-27)
Band: 11p15.5
Quick LinksEntrez ID:8519; OMIM: 604456; Uniprot ID:IFM1_HUMAN; ENSEMBL ID: ENSG00000185885; HGNC ID: 5412
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04662B cell receptor signaling pathway
Pathway IDPathway Name
Signaling in Immune system
No data
No data
Pathway IDPathway Name
500477Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of IFITM1 mRNAaffects expression 17562736
C058317 arsenic disulfide arsenic disulfide results in decreased expression of IFITM1 mRNAdecreases expression 12890387
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of IFITM1 mRNAincreases expression 19152381
D001564 Benzo(a)pyrene chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of IFITM1 mRNA]decreases reaction|increases expression 19152381
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of IFITM1 mRNAincreases expression 20382639
19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of IFITM1 mRNAdecreases expression 15336504
C459604 candoxin candoxin results in decreased expression of IFITM1 mRNAdecreases expression 16309724
C007020 chlorophyllin chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of IFITM1 mRNA]decreases reaction|increases expression 19152381
D002945 Cisplatin Folic Acid affects the reaction [Cisplatin affects the expression of IFITM1 mRNA]affects expression|affects reaction 16898872
D002945 Cisplatin IFITM1 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
18202764
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of IFITM1 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of IFITM1 mRNAincreases expression 19619570
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of IFITM1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IFITM1 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of IFITM1 mRNAdecreases expression 17557909
D005047 Etoposide IFITM1 protein affects the susceptibility to Etoposideaffects response to substance 16217747
D005472 Fluorouracil Fluorouracil results in increased expression of IFITM1 mRNAincreases expression 16510598
16101138
17039268
D005492 Folic Acid Folic Acid affects the reaction [Cisplatin affects the expression of IFITM1 mRNA]affects expression|affects reaction 16898872
C071834 glycidamide glycidamide results in decreased expression of IFITM1 mRNAdecreases expression 17822822
C051890 irinotecan irinotecan analog results in increased expression of IFITM1 mRNAincreases expression 18927307
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of IFITM1 mRNAincreases expression 15860229
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of IFITM1 mRNAincreases expression 12773770
12634122
D008942 Mitoxantrone IFITM1 protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of IFITM1 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of IFITM1 mRNAdecreases expression 19482888
D012643 Selenium Selenium results in increased expression of IFITM1 mRNAincreases expression 19244175
C025462 sulindac sulfide sulindac sulfide results in decreased expression of IFITM1 mRNAdecreases expression 16184548
D013629 Tamoxifen Tamoxifen results in increased expression of IFITM1 mRNAincreases expression 19155303
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of IFITM1 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of IFITM1 mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of IFITM1 mRNAincreases expression 16704738
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IFITM1 mRNAaffects cotreatment|increases expression 17942748
D013876 Thiophenes Thiophenes analog promotes the reaction [Tretinoin results in increased expression of IFITM1 mRNA]increases expression|increases reaction 16140955
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in increased expression of IFITM1 mRNAincreases expression 17951470
D014212 Tretinoin Thiophenes analog promotes the reaction [Tretinoin results in increased expression of IFITM1 mRNA]increases expression|increases reaction 16140955
D014212 Tretinoin Tretinoin results in increased expression of IFITM1 mRNAincreases expression 16140955
16647867
D014810 Vitamin E Vitamin E results in increased expression of IFITM1 mRNAincreases expression 19244175
D015215 Zidovudine [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFITM1 mRNAaffects cotreatment|increases expression 20370541
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3014745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.486195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.4814514962 11752688 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6917505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.589612607
MESH:D058186 Acute Kidney Injury Cisplatin 8.3312690470 15814532 17670903
MESH:D058186 Acute Kidney Injury Folic Acid 8.3316316344 17003819 16595132
MESH:D055371 Acute Lung Injury Lipopolysaccharides 3.8111850527 18653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 12.8520127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 12.8511798837 17638652
MESH:D000230 Adenocarcinoma Estradiol 12.8511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 12.8514692618
MESH:D000230 Adenocarcinoma Fluorouracil 12.8517638652
MESH:D000236 Adenoma Benzo(a)pyrene 6.516695378
MESH:D000236 Adenoma Folic Acid 6.5116963246
MESH:D018248 Adenoma, Liver Cell Phenobarbital 9.2617620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.2616835633
MESH:D000505 Alopecia Tretinoin 3.4215955085
MESH:D000544 Alzheimer Disease Folic Acid 4.6017116317
MESH:D000544 Alzheimer Disease sulindac sulfide 4.6018759972
MESH:D000740 Anemia Fluorouracil 7.9717963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.9711748828
MESH:D000799 Angioedema Acetaminophen 3.5910982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8319183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7115885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.7116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2116292516
MESH:D001249 Asthma Tretinoin 2.2716456186
MESH:D001321 Autistic Disorder Acetaminophen 2.1618445737
MESH:D001321 Autistic Disorder Folic Acid 2.1621388746
MESH:D001471 Barrett Esophagus Tretinoin 4.1716935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.2112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.2116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6115746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 11.3914601052
MESH:D019046 Bone Marrow Neoplasms Etoposide 11.3914601052
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 5.5820146248 17474063
MESH:D001943 Breast Neoplasms Cisplatin 5.5818382427 19526202
MESH:D001943 Breast Neoplasms Estradiol 5.5817289903 18497071 12948864 19861407 17261762 16675129 17018787 14630087
MESH:D001943 Breast Neoplasms Etoposide 5.5816322251
MESH:D001943 Breast Neoplasms Fluorouracil 5.5819217205 16557594 15136595 16110121 16595493 18357371 18608205
MESH:D001943 Breast Neoplasms Folic Acid 5.5816777985
MESH:D001943 Breast Neoplasms Tamoxifen 5.5818821012 18855134 21138602 18351453 19289846 19115204 16818667 19011961 19059307 19189210 19244106 18629630 17242785 19084267 18425577 19221464 20859285 20065188 19487384 15668708 20390343 17893378 18997820 19189212 17049068 16202921 19410462 20544844 20005174 19142967 18984771 20135344 17261762 11161223 19288272 18815881 16273361 15565566 19103187 19155303 19066611 16873071 21152245 17440819 19200415
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.5820435547
MESH:D001943 Breast Neoplasms Tretinoin 5.5816873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3416813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2216111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.6916050911
MESH:D002276 Carcinoid Tumor Fluorouracil 4.4216051944
MESH:D002277 Carcinoma Fluorouracil 7.5517121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.5516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2619066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9116168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.443084413
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 13.4417982673
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.4416924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 13.4418930000 16332177 17088986 17045692 17971768 16799960
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 13.446705139 17173139 1701930 20007298 20935162
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.4416924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.441917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 5.6612023789 16685392
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 5.6612391285
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.9018695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.2020419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 10.2017066447 18337622 6189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.2016757204 18986760 17066447 16280240
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.2016051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4017572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2316120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Folic Acid 3.7816755160
MESH:D002386 Cataract Acetaminophen 6.7510977129
MESH:D002386 Cataract Tretinoin 6.7517460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.3720889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.3718566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 10.372727394
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.014080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3416129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.7017110522 16105132 11677210 16919318 17333356 17681005 15861022
MESH:D002822 Choriocarcinoma Tretinoin 4.9116461808
MESH:D002971 Cleft Lip Folic Acid 3.8521254359
MESH:D002972 Cleft Palate Folic Acid 9.308946559 21254359
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 9.3012621046 15340226 15668235 8697196 16354765
MESH:D002972 Cleft Palate Tretinoin 9.309407595
MESH:D003092 Colitis Selenium 8.6917936198
MESH:D003092 Colitis Tretinoin 8.6917035595
MESH:D003110 Colonic Neoplasms Fluorouracil 3.8017016597 16510598 17018589 15001691 16340194 17725105 17287894 17172411 18772588 17169374
MESH:D003110 Colonic Neoplasms irinotecan 3.8017725105 17287894
MESH:D015179 Colorectal Neoplasms Cisplatin 4.6715273666
MESH:D015179 Colorectal Neoplasms Fluorouracil 4.6717255274 17454858 15289873 18802399 18288408 18383874 14970324 17401013 16391804 15148649 17016601 17695437 18949393 20501625 17594712 16303861 18448328 18509181 17094418 16331619 16282729 16524972
MESH:D015179 Colorectal Neoplasms Folic Acid 4.6717245555 17087956 16985020 17116713 16963246
MESH:D015179 Colorectal Neoplasms irinotecan 4.6716391804 16303861 18259882 17454858 17159606 18509181 15273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8517141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6015322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.609211117 16925845 14991402 10589399 9224671 17551590 8800419 9142499 9664655 9125849
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.6019769572
MESH:D007644 Darier Disease Fluorouracil 4.5416733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1219031437
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 4.3616886840
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3617107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.1619279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.1619279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.7019370779 16177239 10774834 11461765 14550746 16781746 19164858 16109766 19420014 17906064 12540782 15968718 15619225 16227642 2444490 12958197 12153990 11287661 11529661 11421492 12594235 12705907 16393943 19739265 11739529 10915739 12392966 17522070 19923254 18071297 16485898 19085960 11743745 14725611 17562736 16081117 10663392 11834606 18713872 14986274 19416960
MESH:D056486 Drug-Induced Liver Injury Selenium 5.7015131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.7020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8519426721
MESH:D004362 Drug Toxicity Cisplatin 12.7815033597 12649298 12231392 19839026
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 12.7811462148
MESH:D004362 Drug Toxicity Zidovudine 12.7815040536
MESH:D004421 Dystonia Phenobarbital 3.781851702
MESH:C538011 Eales disease Vitamin E 4.459068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.1712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.1115322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.1118230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.1712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.1719031437
MESH:D016889 Endometrial Neoplasms Estradiol 16.5119148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Folic Acid 16.5117301261
MESH:D016889 Endometrial Neoplasms Tamoxifen 16.5119155303 17893378 20544844 16202921
MESH:D016889 Endometrial Neoplasms Tretinoin 16.5116569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8110568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.1515328337 17637181 15821434
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.873659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.623922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.7720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.346401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.017750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.773659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.8720426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 9.8716530937
MESH:D004938 Esophageal Neoplasms Cisplatin 9.8716481741 15464296 17638652 15173087 16785472
MESH:D004938 Esophageal Neoplasms Fluorouracil 9.8717638652 16337965 16785472 15173087 16481741
MESH:D017889 Exfoliation Syndrome Folic Acid 5.2416504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.2411564622
MESH:D005124 Eye Abnormalities Tretinoin 8.2416938888 9664655
MESH:D005234 Fatty Liver Ethinyl Estradiol 11.9215345470
MESH:D005234 Fatty Liver Tamoxifen 11.9214986274 19224547
MESH:D005234 Fatty Liver Zidovudine 11.9218299183
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2111858732
MESH:D005334 Fever Lipopolysaccharides 3.809205823 11852909
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9419069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.8220067830
MESH:D005355 Fibrosis Tretinoin 7.8217994277
MESH:D005756 Gastritis Acetaminophen 10.4416983495
MESH:D005756 Gastritis Folic Acid 10.4417171786
MESH:D005901 Glaucoma Folic Acid 4.8516504073
MESH:D005909 Glioblastoma Tretinoin 2.8517312396
MESH:D005910 Glioma Fluorouracil 2.7716145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3410696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 12.0615464296 15102660
MESH:D006258 Head and Neck Neoplasms Fluorouracil 12.0615162350 15102660 18337622
MESH:D006258 Head and Neck Neoplasms Tretinoin 12.0616096774
MESH:D034381 Hearing Loss Cisplatin 4.0919898482
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9116084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.2215464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 19.6820471113
MESH:D006330 Heart Defects, Congenital Folic Acid 19.6816524890 17286298
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 19.6810048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 19.6814991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin E 19.6816080930
MESH:D006331 Heart Diseases Mitoxantrone 3.9816019553
MESH:D006333 Heart Failure Selenium 2.9317162251
MESH:D006402 Hematologic Diseases Zidovudine 4.4812579204
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.1716366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1211000095
MESH:D006529 Hepatomegaly Phenobarbital 7.6416109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.6416120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6216490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.7815709030
MESH:D006561 Herpes Simplex Etoposide 4.3210809021
MESH:D015658 HIV Infections Zidovudine 3.3620032539 17358032 11698656 11141242 11363243
MESH:D006679 HIV Seropositivity Folic Acid 5.2417209195
MESH:D006689 Hodgkin Disease Cisplatin 7.1316200630 16170182
MESH:D006689 Hodgkin Disease Etoposide 7.1317606976 18180244 16135485 16200630 15147373
MESH:D019584 Hot Flashes Estradiol 9.2217088409
MESH:D019584 Hot Flashes Vitamin E 9.2214716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8016959395 8697196 16354765 15340226 18606429
MESH:D006930 Hyperalgesia Acetaminophen 6.9916870215
MESH:D006930 Hyperalgesia Tretinoin 6.9916870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3316778211
MESH:D020138 Hyperhomocysteinemia Folic Acid 4.2916865747 16395265 16433478 16755160 16397167
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8218670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2312013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3317937319
MESH:D007249 Inflammation Lipopolysaccharides 7.5912878042 17255318 17237260 17963957 9205823
MESH:D007249 Inflammation Tamoxifen 7.5919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.5912200463 12878042
MESH:D007251 Influenza, Human Selenium 10.1316624496
MESH:D007251 Influenza, Human Vitamin E 10.1316624496
MESH:D007333 Insulin Resistance Estradiol 2.8116627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 3.5317994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.4017255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.2016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.2015992940 17551590
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.8915464296
MESH:D007674 Kidney Diseases Acetaminophen 13.3015629191 12587719
MESH:D007674 Kidney Diseases Cisplatin 13.3012649298 19839026 15190930 12231392 18289764
MESH:D007674 Kidney Diseases Estradiol 13.3015618244
MESH:D007674 Kidney Diseases Vitamin E 13.3012488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.6716518626
MESH:D007680 Kidney Neoplasms Estradiol 16.1815610895
MESH:D007680 Kidney Neoplasms Fluorouracil 16.1816985049
MESH:D007680 Kidney Neoplasms Tamoxifen 16.1818625569
MESH:D007680 Kidney Neoplasms Zidovudine 16.1812579204
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.5511231351
MESH:D007938 Leukemia Tretinoin 2.6517143497
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.6818172266
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.1920370541
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic disulfide 4.7312421474
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4819285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0419850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Thiophenes 7.7016140954 16140955
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.7019225113 17294898 17217047 16788101 16766008 19642359 16331271 17339181 12679006 16891316 17506722 19035177 16140955 17361223 17368321 16823087 19029980 9834237 15748426 17712046 17301526 19075265 16935935 17107899 17649720
MESH:D007970 Leukopenia Lipopolysaccharides 4.4515821434
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.139224671
MESH:D008064 Lipidoses Tamoxifen 2.9817567588 15342952
MESH:D008103 Liver Cirrhosis Phenobarbital 2.7621047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.3214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 8.3212878042
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.3218564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.3212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.3216248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 8.3216169303
MESH:D008107 Liver Diseases Acetaminophen 6.2219460945 16611625 12969438 12587719 19014921 16610002 19784758 11587558
MESH:D008107 Liver Diseases Folic Acid 6.2216877991
MESH:D008107 Liver Diseases Phenobarbital 6.2219363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0216871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 13.2221137059 20195826
MESH:D008113 Liver Neoplasms Fluorouracil 13.2217045692 18383874 16603448 15113037
MESH:D008113 Liver Neoplasms Phenobarbital 13.2219812893 19482888 21047994 8742319 19073162 15975961
MESH:D008113 Liver Neoplasms Tamoxifen 13.2216684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.2216984957
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 5.291399818 18308698 17172636 6150874 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.2912151625
MESH:D008171 Lung Diseases Vitamin E 3.0116863852
MESH:D055370 Lung Injury Lipopolysaccharides 3.7721114838
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.2118569708 17053015 20464547 20064080 18816296 18520028 6695378 20869020 20135361
MESH:D008175 Lung Neoplasms Cisplatin 10.2111798837 17225452 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 10.2115246190
MESH:D008175 Lung Neoplasms Tamoxifen 10.2118625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.2119555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 10.2111062179
MESH:D008175 Lung Neoplasms Zidovudine 10.2118800350
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5415086387
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.2717718048
MESH:D008223 Lymphoma Etoposide 3.7512854902 12556972
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5119428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.0511408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Selenium 9.0515318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.0514580682 16827153 11731420 19196722 19196723
MESH:D020149 Manganese Poisoning Estradiol 11.8119453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.8119453300
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.4516832597
MESH:D008527 Medulloblastoma Tretinoin 2.6917453147
MESH:D008545 Melanoma Cisplatin 4.8912374674 17023156 12393984 16809738 18332650 15577323 18176117 17761969 11135225 16248763 12883367 16432458 18505091
MESH:D008545 Melanoma Tamoxifen 4.8919393235 12393984
MESH:D008545 Melanoma Tretinoin 4.8916752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 10.6915990972
MESH:D018328 Melanoma, Amelanotic Tamoxifen 10.6915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3319513568
MESH:D008591 Meningomyelocele Tretinoin 4.1816940565
MESH:D008654 Mesothelioma Cisplatin 6.0317638057
MESH:D008654 Mesothelioma Selenium 6.0315107826
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.5917358032
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.6417671175
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.9116381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.9116757204 18986760
MESH:D052016 Mucositis irinotecan 4.7617159606
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9417596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.0916810080
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2317484760
MESH:D009362 Neoplasm Metastasis irinotecan 5.6218259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.6219393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4419410462
MESH:D009369 Neoplasms Benzo(a)pyrene 14.4611141357
MESH:D009369 Neoplasms Cisplatin 14.4616773208
MESH:D009369 Neoplasms Fluorouracil 14.4618239605 18600527 16928823
MESH:D009369 Neoplasms Mitoxantrone 14.4616640825
MESH:D009369 Neoplasms Tretinoin 14.4616594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7519200415 19189210 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4917289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.2415464296
MESH:D009421 Nervous System Malformations Estradiol 14.9711399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.9714600291
MESH:D009421 Nervous System Malformations Tretinoin 14.979125849
MESH:D009436 Neural Tube Defects Folic Acid 7.0817438019
MESH:D009436 Neural Tube Defects Tretinoin 7.089142499
MESH:D009447 Neuroblastoma Cisplatin 6.808761367
MESH:D009447 Neuroblastoma irinotecan 6.808761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6718514411
MESH:D017599 Neuroectodermal Tumors Cisplatin 10.648761367
MESH:D017599 Neuroectodermal Tumors irinotecan 10.648761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2716436463
MESH:D009503 Neutropenia Folic Acid 4.2816322990
MESH:D010018 Osteomalacia Phenobarbital 4.1217016548
MESH:D010051 Ovarian Neoplasms Cisplatin 7.4719769630 6897625 15464296 17225452
MESH:D010051 Ovarian Neoplasms Estradiol 7.4719401270
MESH:D010051 Ovarian Neoplasms Tretinoin 7.4716936753
MESH:D010146 Pain Acetaminophen 5.9416870215
MESH:D010146 Pain Tretinoin 5.9416870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 15.3819003803
MESH:D010190 Pancreatic Neoplasms Etoposide 15.3819003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 15.3819003803 16929163 16500647 15113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 15.3816965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 15.3815976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4611578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0012520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.0715464296
MESH:D010954 Plasmacytoma Selenium 4.6415087411
MESH:D010997 Pleural Neoplasms Cisplatin 5.0917638057
MESH:D011014 Pneumonia Lipopolysaccharides 4.3111605937 12224865
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3218163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.422563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9511118676 11399792 11222880 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6620887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8817292933
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Etoposide 1.8817172428
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8818626508 19082440
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8815067354
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8815084515
MESH:D011507 Proteinuria Tretinoin 3.3816636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.0715861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.2512752131
MESH:D011625 Pterygium Tretinoin 4.5516723453
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8016160472 18722050 18286688 15538739
MESH:D051437 Renal Insufficiency Cisplatin 9.7815464296
MESH:D051437 Renal Insufficiency Folic Acid 9.7815728788
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.5710835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6018990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8716283617 16116481
MESH:D012512 Sarcoma, Ewing's Cisplatin 9.8414601052
MESH:D012512 Sarcoma, Ewing's Etoposide 9.8414601052
MESH:D012559 Schizophrenia Folic Acid 2.8616641680
MESH:D012640 Seizures Phenobarbital 2.5311442880 3137016 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.576407741
MESH:D012871 Skin Diseases Folic Acid 5.0018709164
MESH:D012871 Skin Diseases Vitamin E 5.0018709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.5919755658 10029692
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 12.598532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.5916192470
MESH:D012878 Skin Neoplasms Tretinoin 12.5916467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.0915464296
MESH:D013088 Spermatocele Ethinyl Estradiol 10.7316709447
MESH:D013088 Spermatocele Tamoxifen 10.7316709447
MESH:D013118 Spinal Cord Diseases Folic Acid 5.2416361298
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7919457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 9.9920155912 2093021
MESH:D013274 Stomach Neoplasms Cisplatin 9.9917522103 18396642 15958060
MESH:D013274 Stomach Neoplasms Fluorouracil 9.9917522103 16951190 16424979 17498489 18396642 19084572 17172411 15786421 18567086 19015929
MESH:D013274 Stomach Neoplasms Folic Acid 9.9917171786
MESH:D013274 Stomach Neoplasms irinotecan 9.9915723263
MESH:D013274 Stomach Neoplasms Tretinoin 9.9917261132
MESH:D013274 Stomach Neoplasms Zidovudine 9.9917696246
MESH:D020521 Stroke Folic Acid 8.2616517955
MESH:D020521 Stroke Vitamin E 8.2616517955
MESH:D013736 Testicular Neoplasms Cisplatin 4.4017225452 15464296
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.9515821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6512697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.581399818
MESH:D013964 Thyroid Neoplasms Tretinoin 6.5816026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.4419048282
MESH:D014062 Tongue Neoplasms Fluorouracil 9.1216280240
MESH:D014062 Tongue Neoplasms Tretinoin 9.1216051514
MESH:D014376 Tuberculosis Tretinoin 3.0816040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.7917053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 7.7915464296 12973940 17225452
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 7.7917572228 16712894 8653321
MESH:D014581 Urticaria Acetaminophen 2.7510982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 14.6916803524
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 14.6916803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 14.6916129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.9114692618
MESH:D014594 Uterine Neoplasms sulindac sulfide 8.9118645019
MESH:D014604 Uveal Neoplasms Tretinoin 4.3616752155
MESH:D014625 Vaginal Neoplasms Cisplatin 10.3915577323
MESH:D014625 Vaginal Neoplasms Zidovudine 10.3912579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3215869587 14671159
MESH:D014820 Vitiligo Tretinoin 3.8216761959
MESH:D014839 Vomiting Cisplatin 4.4711897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0015886252
MESH:D009396 Wilms Tumor Tretinoin 3.7616287080
Pathway ID Pathway Name
KEGG:04662 B cell receptor signaling pathway
REACT:6900 Signaling in Immune system
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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