AutismKB 2.0

Annotation Detail for HIST1H2BK


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Basic Information Top
Gene Symbol:HIST1H2BK ( H2B/S,H2BFAiii,H2BFT,MGC131989 )
Gene Full Name: histone cluster 1, H2bk
Band: 6p22.1
Quick LinksEntrez ID:85236; OMIM: NA; Uniprot ID:H2B1K_HUMAN; ENSEMBL ID: ENSG00000197903; HGNC ID: 13954
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05322Systemic lupus erythematosus
Pathway IDPathway Name
Chromosome Maintenance
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of HIST1H2BK mRNAincreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of HIST1H2BK mRNAincreases expression 20382639
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of HIST1H2BK mRNAincreases expression 15336504
D016572 Cyclosporine Cyclosporine results in increased expression of HIST1H2BK mRNAincreases expression 20106945
D005472 Fluorouracil Fluorouracil results in decreased expression of HIST1H2BK mRNAdecreases expression 16101138
D005472 Fluorouracil Fluorouracil results in increased expression of HIST1H2BK proteinincreases expression 15352031
D005472 Fluorouracil HIST1H2BK protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
15352031
D020366 Methylmethacrylate Methylmethacrylate results in increased expression of HIST1H2BK mRNAincreases expression 16916219
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.6220464547 20127859
MESH:D000230 Adenocarcinoma Fluorouracil 4.6217638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.826695378
MESH:D000740 Anemia Fluorouracil 4.0217963324 15504547 16511603
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4919183758
MESH:D001943 Breast Neoplasms marker/mechanism 17659439
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.1517474063 20146248
MESH:D001943 Breast Neoplasms Fluorouracil 2.1519217205 15136595 16595493 16557594 18357371 18608205 16110121
MESH:D002276 Carcinoid Tumor Fluorouracil 5.1916051944
MESH:D002277 Carcinoma Fluorouracil 3.8217121937
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 2.1116332177 17971768 17045692 17088986 16799960 18930000
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1418695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8920419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.8917066447 16757204 16280240 18986760
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2620889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.2612371664
MESH:D002779 Cholestasis Cyclosporine 3.1419486331
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2717172411 16340194 17287894 18772588 16510598 17169374 15001691 17018589 17725105 17016597
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0015289873 16331619 18949393 15148649 14970324 16524972 18448328 17695437 16303861 18383874 17094418 18509181 17594712 16282729 17255274 17401013 16391804 20501625 17016601 18802399 17454858 18288408
MESH:D007644 Darier Disease Fluorouracil 5.2516733453
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.6220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.6216530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.6216337965 17638652 15173087 16481741 16785472
MESH:D005234 Fatty Liver Cyclosporine 3.1819224547
MESH:D005355 Fibrosis Cyclosporine 3.5612639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D005910 Glioma Fluorouracil 2.9716145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5915102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8020471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006973 Hypertension Cyclosporine 2.1910903974
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.5018776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 8.3012371664
MESH:D007680 Kidney Neoplasms Fluorouracil 8.3016985049
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.9420195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 4.9417045692 18383874 15113037 16603448
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.5420064080 18569708 17053015 20464547 20869020 18816296 6695378 20135361 18520028
MESH:D008175 Lung Neoplasms Fluorouracil 2.5415246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.2515086387
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.3416381670
MESH:D009062 Mouth Neoplasms Fluorouracil 9.3416757204 18986760
MESH:D009369 Neoplasms Benzo(a)pyrene 5.5211141357
MESH:D009369 Neoplasms Fluorouracil 5.5218600527 16928823 18239605
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5718481113 19348381
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6416436463
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7515113037 16929163 16500647 19003803
MESH:D011230 Precancerous Conditions Cyclosporine 3.5112371664
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1617292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.1618626508 19082440
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3016160472 15538739 18286688 18722050
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.1410029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 6.148532709
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.482093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4817522103 15786421 16424979 16951190 18396642 18567086 17172411 17498489 19084572 19015929
MESH:D014062 Tongue Neoplasms Fluorouracil 4.2916280240
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2817053015
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.1816803524
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
Pathway ID Pathway Name
REACT:22172 Chromosome Maintenance
REACT:27271 Meiotic Recombination
REACT:27235 Meiotic Recombination (mouse)
KEGG:05322 Systemic lupus erythematosus
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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