AutismKB 2.0

Annotation Detail for DGKZ


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Basic Information Top
Gene Symbol:DGKZ ( DAGK5,DAGK6,DGK-ZETA,hDGKzeta )
Gene Full Name: diacylglycerol kinase, zeta 104kDa
Band: 11p11.2
Quick LinksEntrez ID:8525; OMIM: 601441; Uniprot ID:DGKZ_HUMAN; ENSEMBL ID: ENSG00000149091; HGNC ID: 2857
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00561Glycerolipid metabolism
hsa00564Glycerophospholipid metabolism
hsa01100Metabolic pathways
hsa04070Phosphatidylinositol signaling system
Pathway IDPathway Name
Signaling by GPCR
Hemostasis
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of DGKZ mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of DGKZ mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DGKZ mRNAaffects expression 16483693
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in increased expression of DGKZ mRNAincreases expression 17553608
D004075 Diglycerides DGKZ protein inhibits the reaction [Phenylephrine results in increased abundance of Diglycerides]decreases reaction|increases abundance 16380548
D007657 Ketone Bodies Ketone Bodies results in increased expression of DGKZ mRNAincreases expression 16807920
D010656 Phenylephrine DGKZ protein inhibits the reaction [Phenylephrine results in increased abundance of Diglycerides]decreases reaction|increases abundance 16380548
D010656 Phenylephrine DGKZ protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]decreases reaction|increases expression 16380548
D018038 Sodium Selenite Sodium Selenite results in increased expression of DGKZ mRNAincreases expression 18175754
D013654 Taurine Taurine results in increased expression of DGKZ mRNAincreases expression 16579726
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of DGKZ mRNAdecreases expression 16054898
D014212 Tretinoin Tretinoin results in increased expression of DGKZ mRNAincreases expression 17218384
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0414514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000505 Alopecia Tretinoin 3.7315955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.2417460149
MESH:D001169 Arthritis, Experimental Tretinoin 3.1616412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2916292516
MESH:D001249 Asthma Tretinoin 2.3816456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001471 Barrett Esophagus Tretinoin 4.5616935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.4116197459 16206674
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001919 Bradycardia Phenylephrine 4.7415306635
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9716166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7816813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3816168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.643084413
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.641917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3216051514 16096774
MESH:D006332 Cardiomegaly Phenylephrine 7.1216170337 11179087 17287366 15728586 17124262 11754973
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.1218850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 7.4810977129
MESH:D002386 Cataract Tretinoin 7.4817460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.866135515
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7816129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002822 Choriocarcinoma Tretinoin 5.3816461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9315894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.948697196 12621046 15668235 15340226 16354765
MESH:D002972 Cleft Palate Tretinoin 5.949407595
MESH:D003092 Colitis Tretinoin 3.8817035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4815322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.4814991402 10589399 9224671 17551590 9211117 16925845 9664655 8800419 9125849 9142499
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1918551238
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9016285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D058065 Diabetic Cardiomyopathies Taurine 6.2516025228
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.4521346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.4512540782 16081117 14550746 11834606 11287661 11421492 10915739 12705907 11529661 16227642 17906064 11461765 19739265 19085960 19370779 17522070 15619225 16781746 12594235 10774834 12392966 14986274 17562736 14725611 19164858 18071297 18713872 15968718 19420014 16109766 16485898 12958197 11739529 16177239 11743745 19416960 12153990 2444490 19923254 10663392 16393943
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 12.4515131321
MESH:D056486 Drug-Induced Liver Injury Taurine 12.459328219
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.4520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.6816714409 18230668 15322242
MESH:D004489 Edema, Cardiac Tretinoin 12.6818230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1916569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1510568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.1811564622
MESH:D005124 Eye Abnormalities Tretinoin 9.189664655 16938888
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2120067830
MESH:D005355 Fibrosis Tretinoin 9.2117994277
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005909 Glioblastoma Tretinoin 3.0917312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3816084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7611294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.769664655 14991402
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0715340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2616354765 18606429 16959395 8697196 15340226
MESH:D006930 Hyperalgesia Acetaminophen 8.0016870215
MESH:D006930 Hyperalgesia Tretinoin 8.0016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7416778211
MESH:D006973 Hypertension Phenylephrine 5.4612717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.4618850075 18670907
MESH:D006984 Hypertrophy Phenylephrine 4.6918502941 12791704
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9212200463 12878042
MESH:D007333 Insulin Resistance Sodium Selenite 3.3614714311
MESH:D007410 Intestinal Diseases Tretinoin 3.9417994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.4016580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.4017551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 2.2712587719 15629191
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.0916705839
MESH:D007938 Leukemia Tretinoin 2.8317143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8416482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1019850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2419642359 16788101 9834237 19075265 17217047 17506722 17294898 12679006 17107899 19225113 19035177 15748426 17361223 16331271 17339181 16766008 16891316 16935935 16823087 17301526 16140955 19029980 17649720 17368321 17712046
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.419224671
MESH:D008106 Liver Cirrhosis, Experimental Taurine 3.7315893842 15931870
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.7312878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.7318397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.6616610002 19460945 12587719 12969438 11587558 19014921 16611625 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3716871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.537678174
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.012876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.0112151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2114737004
MESH:D008527 Medulloblastoma Tretinoin 2.8317453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008591 Meningomyelocele Tretinoin 4.6016940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1517596541
MESH:D009203 Myocardial Infarction therapeutic 17071729
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.0518551238 7678174
MESH:D009369 Neoplasms Tretinoin 2.4716946489 16594593
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.0614600291
MESH:D009421 Nervous System Malformations Tretinoin 10.069125849
MESH:D009436 Neural Tube Defects Tretinoin 3.149142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5616049721
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3816936753
MESH:D010146 Pain Acetaminophen 6.9816870215
MESH:D010146 Pain Tretinoin 6.9816870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5015976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3718760546
MESH:D011507 Proteinuria Tretinoin 3.7516636307
MESH:D011625 Pterygium Tretinoin 4.9916723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2516116481 16283617
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6218551238
MESH:D012852 Sinusitis Phenylephrine 4.907327846
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7616192470
MESH:D012878 Skin Neoplasms Tretinoin 5.7616467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1317045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.9216051514
MESH:D014376 Tuberculosis Tretinoin 3.3116040207
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3316049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5110091137
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8116129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.8316752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D014820 Vitiligo Tretinoin 4.2216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D009396 Wilms Tumor Tretinoin 4.0916287080
Pathway ID Pathway Name
KEGG:00561 Glycerolipid metabolism
KEGG:00564 Glycerophospholipid metabolism
REACT:604 Hemostasis
KEGG:01100 Metabolic pathways
KEGG:04070 Phosphatidylinositol signaling system
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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