AutismKB 2.0

Annotation Detail for CYP4F2


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Basic Information Top
Gene Symbol:CYP4F2 ( CPF2 )
Gene Full Name: cytochrome P450, family 4, subfamily F, polypeptide 2
Band: 19p13.12
Quick LinksEntrez ID:8529; OMIM: 604426; Uniprot ID:CP4F2_HUMAN; ENSEMBL ID: ENSG00000186115; HGNC ID: 2645
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6377alpha-tocopherol degradation
Pathway IDPathway Name
hsa00590Arachidonic acid metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Biological oxidations
No data
No data
Pathway IDPathway Name
500201Eicosanoids
Related Diseases/Disorders Top
No data
No data
Desease Name
Cerebral Infarction
CARDIOVASCULAR
PHARMACOGENOMIC
hypertension
Brain Ischemia
Acenocoumarol maintenance dosage
Stroke
warfarin maintenance dose
Desease Name
Acenocoumarol maintenance dosage
Warfarin maintenance dose
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000074 Acenocoumarol CYP4F2 gene polymorphism affects the susceptibility to Acenocoumarolaffects response to substance 19578179
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of CYP4F2 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CYP4F2 mRNAdecreases expression 20106945
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CYP4F2 mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in decreased expression of CYP4F2 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CYP4F2 mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP4F2 mRNAaffects cotreatment|decreases expression 18544905
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of CYP4F2 mRNAdecreases expression 19638242
D004958 Estradiol Estradiol results in decreased expression of CYP4F2 mRNAdecreases expression 20106945
D011345 Fenofibrate Fenofibrate results in decreased expression of CYP4F2 proteindecreases expression 15964316
D007654 Ketoconazole Ketoconazole results in decreased activity of CYP4F2 proteindecreases activity 14709627
C011890 kojic acid [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP4F2 mRNAaffects cotreatment|decreases expression 18544905
C503100 N-(3-chloro-4-morpholin-4-yl) phenyl-N'-hydroxyimido formamide N-(3-chloro-4-morpholin-4-yl) phenyl-N'-hydroxyimido formamide results in decreased activity of CYP4F2 proteindecreases activity 15831442
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CYP4F2 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of CYP4F2 proteindecreases expression 15964316
D014812 Vitamin K CYP4F2 protein affects the metabolism of Vitamin Kaffects metabolic processing 19741565
D014859 Warfarin CYP4F2 gene affects the susceptibility to Warfarinaffects response to substance 19207028
D014859 Warfarin CYP4F2 gene polymorphism affects the susceptibility to Warfarinaffects response to substance 19270263
20217574
19300499
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3220464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 4.3211473722
MESH:D000236 Adenoma Benzo(a)pyrene 6.736695378
MESH:D000236 Adenoma Diethylnitrosamine 6.736695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.3717162532 19052882 18056438 17620307 16434500 19061943
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.3716434500
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1519183758
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2019483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8617474063 20146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8617474063
MESH:D001943 Breast Neoplasms Estradiol 1.8619861407 16675129 17261762 12948864 17289903 14630087 17018787 18497071
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5516111702
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.7612619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.7618785209 16288022 16807293 20524982 18665156 17428255 19519916 18506893 18978308 20935162 19822196 17138121 20084675 17978847 19394651 19171122 19335982 17173139 3581430 19539802 19418558 11831363 21159647 17162532 16698587 16569478 10737359 16328049 20512989 19052882 20007298 18691550 16540662 16935385 16830150 18494052 16779866 16681979 19701751 17055752 19208518 19107877 20514400 20101231 18210153 20214788 20727157 3084413 18056438 20432363 19383236 18393292 16502159 17761372 10672840 18971187 16878318 19919837 18788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.7616924424
MESH:D006528 Carcinoma, Hepatocellular Vitamin K 6.7616328049
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0620419170
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.3712371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.3717174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.3718566989
MESH:D002543 Cerebral Hemorrhage Warfarin 5.9111061249
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7319052882
MESH:D002779 Cholestasis Cyclosporine 7.8919486331
MESH:D002779 Cholestasis pirinixic acid 7.8919176532
MESH:D023903 Coronary Restenosis Warfarin 5.7412872399
OMIM:122700 COUMARIN RESISTANCE Warfarin 5.8820497562 20579077
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003922 Diabetes Mellitus, Type 1 Warfarin 4.0718772604
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2020387270
MESH:D003928 Diabetic Nephropathies Estradiol 9.6019279558
MESH:D003928 Diabetic Nephropathies Warfarin 9.6012644472
MESH:D003875 Drug Eruptions Warfarin 6.0514723717
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 4.4819107877
MESH:D056486 Drug-Induced Liver Injury Ketoconazole 4.4818289764
MESH:D050171 Dyslipidemias Fenofibrate 4.4616707586
MESH:D004487 Edema pirinixic acid 2.5312083418
MESH:D016889 Endometrial Neoplasms Estradiol 7.8918566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Fenofibrate 7.8916569247
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2116302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0216530937
MESH:D005234 Fatty Liver Cyclosporine 13.3719224547
MESH:D005234 Fatty Liver Diethylnitrosamine 13.3721071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 13.3719236843 20131406
MESH:D005355 Fibrosis Cyclosporine 3.2112639820 12168785
MESH:D006471 Gastrointestinal Hemorrhage Warfarin 6.8111794436
MESH:D005776 Gaucher Disease Warfarin 6.0212359135
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6820471113
MESH:D006333 Heart Failure pirinixic acid 2.5720558911
MESH:D006406 Hematoma Warfarin 6.8117493413
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006470 Hemorrhage Warfarin 5.5118429757
MESH:D006529 Hepatomegaly pirinixic acid 3.0719772884 18467677 19176532 16221962
MESH:D006558 Herpes Genitalis Estradiol 5.1315709030
MESH:D019584 Hot Flashes Estradiol 3.8517088409
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006973 Hypertension Cyclosporine 2.1210903974
MESH:D006976 Hypertension, Pulmonary Warfarin 4.8412359135
MESH:D007249 Inflammation Diethylnitrosamine 2.4018785209
MESH:D007333 Insulin Resistance Estradiol 7.3116393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.3116306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007674 Kidney Diseases Cyclosporine 6.048314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 6.0415618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.4212371664
MESH:D007680 Kidney Neoplasms Estradiol 7.4215610895
MESH:D016773 Leishmaniasis, Cutaneous Ketoconazole 4.748889330 2166429 19744259 1311351
MESH:D007898 Leishmaniasis, Visceral Ketoconazole 4.5811332679
MESH:D008064 Lipidoses Ketoconazole 4.6017567588
MESH:D054068 Livedo Reticularis Warfarin 6.8118280355
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8520032147 18407596 18522880 19638242 18665156
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.6214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 3.6215474484
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.6215474484
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1117034775
MESH:D008113 Liver Neoplasms Aflatoxin B1 18.269163691 18177683 2125692 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 18.2621137059 20195826
MESH:D008113 Liver Neoplasms Clofibric Acid 18.2617602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 18.2619294768 19073162 18754104 19255062 19090486 19642983 18644402 19551842 20452335 21167192 15885732 21071580 20501860 2422723 18978307 20434301 15175105 20405173 20118626 19427195 19812893 2862719 19499222 10737359 20101389 20492335 18648771 19850985 19638242 20583210 19254457 19833225 18977376 16942905 12112319 21047994 9163691 19996281 19256749 21278145 19426721 12771043 19690152 20137499
MESH:D008113 Liver Neoplasms Fenofibrate 18.2618978307
MESH:D008113 Liver Neoplasms pirinixic acid 18.2615890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 14.508603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.5018308698 18079962 19126423 19009564 17854601 21159647 16842330 18544905 9362446 17174075 18093689 19004024 17942915 16267830 18282651 18775883 19519916 19539802 3124819 18253720 2563599 18164116
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 14.5018253720 18775883
MESH:D008114 Liver Neoplasms, Experimental kojic acid 14.5018544905
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4614755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4620464547 20869020 18520028 6695378 20135361 20064080 17053015 18816296 18569708
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.4620970405 6695378 20512841 21163286
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.5916891317 17203775 11408345 11807958
MESH:D020149 Manganese Poisoning Estradiol 4.5819453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2316381670
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1619151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.3916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.3916411023
MESH:D009336 Necrosis Warfarin 5.6314723717
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.599029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9011141357
MESH:D009369 Neoplasms pirinixic acid 4.9017405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8117289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3319348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 3.7211399458 16427766
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.3920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2120387270
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D010051 Ovarian Neoplasms Estradiol 2.2319401270
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4416540662
MESH:D011230 Precancerous Conditions Cyclosporine 9.1012371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.102563599
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9420887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6917292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.6916740699
MESH:D011471 Prostatic Neoplasms Ketoconazole 2.6917404083
MESH:D020151 Protein C Deficiency Warfarin 6.4318376272
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D011655 Pulmonary Embolism Warfarin 6.4319300499
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D012851 Sinus Thrombosis, Intracranial Warfarin 5.9412269725
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.3910029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3420155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3418456281
MESH:D020521 Stroke Warfarin 5.0219300499
MESH:D013923 Thromboembolism Acenocoumarol 14.4718698879
MESH:D013923 Thromboembolism Warfarin 14.4716960144 18698879
MESH:D019851 Thrombophilia Warfarin 5.6517493413
MESH:D013927 Thrombosis Warfarin 5.1711307788 17245631 17672075 11518727 19300499 15720958
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.027505956
MESH:D013978 Tibial Fractures Estradiol 4.7819048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2017053015
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D014657 Vasculitis Warfarin 5.9420337814
MESH:D054556 Venous Thromboembolism Warfarin 6.4618776969
MESH:D020246 Venous Thrombosis Warfarin 5.5615733061 14723717
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
Pathway ID Pathway Name
KEGG:00590 Arachidonic acid metabolism
REACT:13433 Biological oxidations
KEGG:01100 Metabolic pathways
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27121
    • Releated gene ID Related gene Name
    PA27121CYP4F2
    Releated disease ID Related disease Name
    PA443459Atrial Fibrillation
    PA444552Hypertension
    PA443425Arteriosclerosis
    PA444368Heart Diseases
    PA444417Hemorrhage
    PA446997Intracranial Hemorrhages
    PA445019Myocardial Infarction
    PA153619833Peripheral Vascular Diseases
    PA445465Pulmonary Embolism
    PA447054Stroke
    PA445848Thromboembolism
    PA447298venous thromboembolism
    PA446969Venous Thrombosis
    Releated drug ID Related drug Name
    PA452632acenocoumarol
    PA451906warfarin
    PA452363prostaglandins
    PA451906warfarin
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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