AutismKB 2.0

Annotation Detail for PPIL4


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Basic Information Top
Gene Symbol:PPIL4 ( HDCME13P )
Gene Full Name: peptidylprolyl isomerase (cyclophilin)-like 4
Band: 6q25.1
Quick LinksEntrez ID:85313; OMIM: 607609; Uniprot ID:PPIL4_HUMAN; ENSEMBL ID: ENSG00000131013; HGNC ID: 15702
Relate to Another Database: SFARIGene; denovo-db
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Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PPIL4 mRNAaffects expression 21346803
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PPIL4 mRNAdecreases expression 20018196
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of PPIL4 mRNAaffects cotreatment|increases expression 17183730
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in decreased expression of PPIL4 mRNAdecreases expression 17616710
D011794 Quercetin Quercetin affects the expression of PPIL4 proteinaffects expression 15221776
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of PPIL4 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.958875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2519490988
MESH:D000550 Amblyopia Valproic Acid 5.7517688650
MESH:D000743 Anemia, Hemolytic Quercetin 4.5717084956
MESH:D001008 Anxiety Disorders Valproic Acid 3.8317497229
MESH:D001260 Ataxia Telangiectasia Quercetin 5.4415336622
MESH:D001321 Autistic Disorder Valproic Acid 1.9916609825 17507914 20603192 15238991 18396377 17688650 19232924 18558336 18177632 17157402 18940202 18985861 18775368 18316065 19460635
MESH:D001327 Autoimmune Diseases Quercetin 4.8219761891
MESH:D001714 Bipolar Disorder Valproic Acid 3.2117594078 20046352
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.598888407
MESH:D001943 Breast Neoplasms Quercetin 2.6318628248
MESH:D002105 Cadmium Poisoning Quercetin 6.0716962696
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.2716705839
MESH:D006528 Carcinoma, Hepatocellular Quercetin 3.2719519916 12508355
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.3717234771
MESH:D006332 Cardiomegaly Quercetin 3.4719794523
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9320889678
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8020734317
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.7320423518
MESH:D003110 Colonic Neoplasms Quercetin 2.4619440933 11134977 19056647 17191121 15741050 17148506 16640504
MESH:D015179 Colorectal Neoplasms Quercetin 2.1918852136 18095365
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 16575769 8888407
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.4318551238
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 4.0019496084
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 4.1818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.1819641884 1733752
MESH:D004421 Dystonia Valproic Acid 4.401851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.5717275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.443922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0720417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.877562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.717750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.533659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D005234 Fatty Liver Valproic Acid 3.6214986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.4116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.5118558336 8888407
MESH:D005355 Fibrosis Quercetin 4.3219474275
MESH:D005909 Glioblastoma Quercetin 3.5819804834
MESH:D005910 Glioma Quercetin 3.1517643826
MESH:D006849 Hydrocephalus Valproic Acid 5.3317688650
MESH:D006943 Hyperglycemia Quercetin 4.3418262572 11834736
MESH:D006973 Hypertension Quercetin 2.9518356687
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 5.0416612254
MESH:D007251 Influenza, Human Quercetin 5.0316624496
MESH:D007627 Keloid Quercetin 5.3717086741
MESH:D007674 Kidney Diseases Quercetin 3.2616962696
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.2416705839
MESH:D007938 Leukemia Quercetin 3.2917468513
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1916294345 17596541
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 2.2012741479
MESH:D008113 Liver Neoplasms Quercetin 2.7618980244
MESH:D008114 Liver Neoplasms, Experimental Quercetin 3.2419519916
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7817228818
MESH:D008175 Lung Neoplasms Quercetin 2.1916280456
MESH:D008881 Migraine Disorders Valproic Acid 3.4118803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.358888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3117596541
MESH:D009203 Myocardial Infarction Quercetin 3.1019595682
MESH:D015428 Myocardial Reperfusion Injury Quercetin 4.0319207477
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.3218551238
MESH:D009369 Neoplasms Quercetin 2.9215185748
MESH:D009436 Neural Tube Defects Valproic Acid 3.3216359493 8888407
MESH:D020078 Neurogenic Inflammation Quercetin 4.7117929310
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.7316049721 12819281
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.5719495926
MESH:D010051 Ovarian Neoplasms Quercetin 2.8119005980
MESH:D010190 Pancreatic Neoplasms Quercetin 2.9416965848
MESH:D011230 Precancerous Conditions Quercetin 4.2719056647
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.2920603192
MESH:D011471 Prostatic Neoplasms Quercetin 3.5517292933 14715546
MESH:D019310 Pseudolymphoma Valproic Acid 5.0611422049 12752131
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.5319155313
MESH:D012554 Schistosomiasis japonica Quercetin 6.0716862918
MESH:D012559 Schizophrenia Valproic Acid 2.1019110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 6.6318551238
MESH:D012640 Seizures Valproic Acid 6.6314763951 3137016 11738929 1511512 17978042 11044598 15475178 16876388
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0219490988
MESH:D013226 Status Epilepticus Valproic Acid 5.0612833885
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 5.4115864552
MESH:D014178 Translocation, Genetic Valproic Acid 5.7517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.983119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.5516049721
MESH:D001749 Urinary Bladder Neoplasms Quercetin 5.5516720314
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.068888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7810091137
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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