AutismKB 2.0

Annotation Detail for PAQR8


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Basic Information Top
Gene Symbol:PAQR8 ( C6orf33,FLJ32521,FLJ46206,LMPB1,MPRB )
Gene Full Name: progestin and adipoQ receptor family member VIII
Band: 6p12.2
Quick LinksEntrez ID:85315; OMIM: 607780; Uniprot ID:MPRB_HUMAN; ENSEMBL ID: ENSG00000170915; HGNC ID: 15708
Relate to Another Database: SFARIGene; denovo-db
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Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PAQR8 mRNAdecreases expression 20064835
D016572 Cyclosporine Cyclosporine results in decreased expression of PAQR8 mRNAdecreases expression 20106945
D005472 Fluorouracil Fluorouracil results in decreased expression of PAQR8 mRNAdecreases expression 17039268
C056507 gemcitabine gemcitabine results in increased expression of PAQR8 mRNAincreases expression 17039268
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.6620127859 20464547
MESH:D000230 Adenocarcinoma Fluorouracil 4.6617638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.866695378
MESH:D000740 Anemia Fluorouracil 4.1116511603 15504547 17963324
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.6419183758
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0517474063 20146248
MESH:D001943 Breast Neoplasms Fluorouracil 2.0516110121 15136595 18357371 19217205 16557594 16595493 18608205
MESH:D001943 Breast Neoplasms gemcitabine 2.0517039268 18382427
MESH:D002276 Carcinoid Tumor Fluorouracil 5.3916051944
MESH:D002277 Carcinoma Fluorouracil 3.8917121937
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 2.1217045692 17088986 16332177 16799960 17971768 18930000
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1718695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.9520419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.9518986760 17066447 16757204 16280240
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7912371664
MESH:D002779 Cholestasis Cyclosporine 3.2119486331
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2815001691 16510598 17287894 17018589 17172411 16340194 17016597 17725105 18772588 17169374
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0018802399 16524972 15289873 16303861 17094418 15148649 17255274 18509181 17016601 18383874 18448328 17594712 20501625 18288408 16391804 18949393 14970324 16282729 17401013 17695437 17454858 16331619
MESH:D007644 Darier Disease Fluorouracil 5.4216733453
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.7516530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.7515173087 16337965 17638652 16481741 16785472
MESH:D005234 Fatty Liver Cyclosporine 3.2819224547
MESH:D005355 Fibrosis Cyclosporine 3.7012168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.858708960
MESH:D005910 Glioma Fluorouracil 2.9916145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.6415162350 15102660 18337622
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8320471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.0515720958
MESH:D006973 Hypertension Cyclosporine 2.2110903974
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.1615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.5418776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 8.5612371664
MESH:D007680 Kidney Neoplasms Fluorouracil 8.5616985049
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 5.0220195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 5.0215113037 18383874 17045692 16603448
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.5518520028 18816296 17053015 18569708 20464547 20869020 20064080 20135361 6695378
MESH:D008175 Lung Neoplasms Fluorouracil 2.5515246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.4215086387
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.5116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.5716381670
MESH:D009062 Mouth Neoplasms Fluorouracil 9.5716757204 18986760
MESH:D009369 Neoplasms Benzo(a)pyrene 5.6311141357
MESH:D009369 Neoplasms Fluorouracil 5.6318600527 16928823 18239605
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.1617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6518481113 19348381
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6916436463
MESH:D010190 Pancreatic Neoplasms Fluorouracil 6.1216929163 19003803 15113037 16500647
MESH:D010190 Pancreatic Neoplasms gemcitabine 6.1211504793 16929163 17440100 18992248 18383843
MESH:D011230 Precancerous Conditions Cyclosporine 3.5912371664
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1517292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.1519082440 18626508
MESH:D011565 Psoriasis Cyclosporine 2.3316882103
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3815538739 18722050 16160472 18286688
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5219755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4920155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4919015929 18396642 16951190 17522103 15786421 16424979 19084572 17172411 17498489 18567086
MESH:D014062 Tongue Neoplasms Fluorouracil 4.3816280240
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.3017053015
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.2716803524
MESH:D014605 Uveitis Cyclosporine 4.711336536
MESH:D014985 Xerophthalmia Cyclosporine 5.1617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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