AutismKB 2.0

Annotation Detail for CPZ


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Basic Information Top
Gene Symbol:CPZ ( MGC99682 )
Gene Full Name: carboxypeptidase Z
Band: 4p16.1
Quick LinksEntrez ID:8532; OMIM: 603105; Uniprot ID:CBPZ_HUMAN; ENSEMBL ID: ENSG00000109625,ENSG00000155269; HGNC ID: 2333
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CPZ mRNAaffects expression 21346803
C000188 alachlor alachlor results in increased expression of CPZ mRNAincreases expression 12419858
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CPZ mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CPZ mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CPZ mRNAaffects cotreatment|increases expression 18164116
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of CPZ mRNAaffects cotreatment|decreases expression 17404688
D005419 Flavonoids Flavonoids results in decreased expression of CPZ mRNAdecreases expression 18035473
D008628 Mercury Mercury results in increased expression of CPZ mRNAincreases expression 16823088
D015735 Mifepristone Mifepristone results in increased expression of CPZ mRNAincreases expression 17584828
D010795 Phthalic Acids Phthalic Acids results in increased expression of CPZ mRNAincreases expression 15728792
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of CPZ mRNAaffects cotreatment|decreases expression 17404688
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000230 Adenocarcinoma Estradiol 2.1311473722
MESH:D000236 Adenoma beta-Naphthoflavone 7.1419389873
MESH:D000236 Adenoma Diethylnitrosamine 7.146695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.0919061943 17162532 16434500 18056438 19052882 17620307
MESH:D000382 Agricultural Workers' Diseases alachlor 4.8511874814 14769641
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.4520106747
MESH:D001321 Autistic Disorder Mercury 2.7717497416
MESH:D001327 Autoimmune Diseases Mercury 5.0516634805
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.5617868700
MESH:D001930 Brain Injuries Progesterone 4.4315380490 15845082 15665606
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9117474063
MESH:D001943 Breast Neoplasms Estradiol 1.9117289903 19861407 12948864 17018787 14630087 18497071 17261762 16675129
MESH:D001943 Breast Neoplasms Progesterone 1.9117614352 15562024 16175315
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6616111702
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6816705839
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.6819519916 17162532 18506893 19383236 3581430 19107877 17978847 17428255 16807293 20007298 17055752 20524982 18210153 20432363 19208518 18494052 19335982 20935162 19052882 18691550 19539802 16681979 16878318 18056438 17173139 18971187 10672840 21159647 18393292 10737359 19919837 18665156 20084675 11831363 17761372 16779866 19171122 19418558 19701751 19822196 19394651 20101231 18785209 18978308 16288022 16328049 3084413 16502159 20514400 20512989 17138121 16830150 18788625 16698587 20214788 16569478 20727157 16935385 16540662
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.6816924424
MESH:D002311 Cardiomyopathy, Dilated Mercury 3.4910334427
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.746135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.747505956 17174075 2727394 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.7418566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8119052882
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1918551238
MESH:D017449 Dermatitis, Allergic Contact alachlor 8.288428444
MESH:D017449 Dermatitis, Allergic Contact Mercury 8.2816823706
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2220387270
MESH:D003928 Diabetic Nephropathies Estradiol 3.5419279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.6717187935
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.0121346803 18551238
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 4.0119107877
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.9417692515
MESH:D016889 Endometrial Neoplasms Estradiol 3.0711473722 19148513 18566989
MESH:D004715 Endometriosis Mifepristone 9.8716134523
MESH:D004715 Endometriosis Progesterone 9.8716134523
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3316302075
MESH:D005234 Fatty Liver Diethylnitrosamine 3.3220387270 21071580
MESH:D006558 Herpes Genitalis Estradiol 5.2515709030
MESH:D019584 Hot Flashes Estradiol 3.9717088409
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5815869954
MESH:D007248 Infertility, Male alachlor 4.2317049205 12948887 16466525
MESH:D007249 Inflammation Diethylnitrosamine 8.8118785209
MESH:D007249 Inflammation Flavonoids 8.8117296493
MESH:D007249 Inflammation Progesterone 8.8115869954
MESH:D007333 Insulin Resistance Estradiol 3.0516393666 16627594
MESH:D007674 Kidney Diseases Estradiol 6.6415618244
MESH:D007674 Kidney Diseases Mercury 6.6417934191
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.7616705839
MESH:D007680 Kidney Neoplasms Estradiol 7.7615610895
MESH:D007938 Leukemia alachlor 4.0814769641
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8918407596 20032147 18522880 18665156 19638242
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814659978 14716833
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1317034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.807678174
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 7.8019389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.8019255062 21071580 20434301 16942905 20583210 20118626 19254457 19833225 19996281 18978307 18648771 19427195 19294768 2422723 20101389 19256749 19850985 15885732 21167192 19090486 18977376 9163691 15175105 19073162 21047994 19551842 18754104 2862719 19499222 20501860 20405173 19642983 19812893 12771043 18644402 20492335 19638242 19426721 12112319 20137499 21278145 20452335 10737359 19690152
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.412876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.4118164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.4117174075 19009564 21159647 18079962 19126423 18544905 18164116 17942915 18253720 18093689 19004024 19539802 19519916 18775883 2563599 3124819 9362446 16267830 17854601 16842330 18282651 18308698
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7620512841 21163286 6695378 20970405
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.3516891317 11408345 11807958 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.3517203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.7019453300
MESH:D009101 Multiple Myeloma alachlor 4.3814769641
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3916810080
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.0518551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.619029167 3581430
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9317289903
MESH:D009421 Nervous System Malformations Estradiol 3.8111399458 16427766
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3320387270
MESH:D009669 Nose Neoplasms alachlor 5.0111127290 15580706 16698726 14563481 16178123
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5616049721
MESH:D010051 Ovarian Neoplasms Estradiol 8.2219401270
MESH:D010051 Ovarian Neoplasms Mifepristone 8.2216525653
MESH:D010051 Ovarian Neoplasms Progesterone 8.2217393432 16525653
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4616540662
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.682563599
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0220887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0616740699
MESH:D012135 Respiratory Sounds alachlor 5.1211874814
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9018045962
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6218551238
MESH:D013119 Spinal Cord Injuries Progesterone 4.4716503802 15862959
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms alachlor 7.998812207
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.997505956
MESH:D013978 Tibial Fractures Estradiol 4.9019048282
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3316049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5110091137
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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