AutismKB 2.0

Annotation Detail for CAMK1


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Basic Information Top
Gene Symbol:CAMK1 ( CAMKI,MGC120317,MGC120318 )
Gene Full Name: calcium/calmodulin-dependent protein kinase I
Band: 3p25.3
Quick LinksEntrez ID:8536; OMIM: 604998; Uniprot ID:KCC1A_HUMAN; ENSEMBL ID: ENSG00000134072; HGNC ID: 1459
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CAMK1 mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of CAMK1 mRNAdecreases expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of CAMK1 proteinincreases expression 16845489
D002794 Choline Choline results in increased expression of CAMK1 mRNAincreases expression 17264169
D002794 Choline Choline results in increased expression of CAMK1 proteinincreases expression 17264169
C057862 cyanoginosin LR cyanoginosin LR results in increased expression of CAMK1 mRNAincreases expression 17654400
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CAMK1 mRNAaffects cotreatment|increases expression 17942748
C087869 histamine trifluoromethyl-toluidide histamine trifluoromethyl-toluidide results in increased phosphorylation of CAMK1 proteinincreases phosphorylation 18508907
C072105 KN 93 KN 93 results in decreased activity of CAMK1 proteindecreases activity 12193581
C029938 nickel sulfate nickel sulfate results in increased expression of CAMK1 mRNAincreases expression 16780908
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CAMK1 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of CAMK1 mRNAdecreases expression 18445702
D011794 Quercetin Quercetin results in decreased expression of CAMK1 mRNAdecreases expression 15309432
C458525 STO 609 STO 609 results in increased phosphorylation of and results in increased activity of CAMK1 proteinincreases activity|increases phosphorylation 18755850
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CAMK1 mRNAaffects cotreatment|increases expression 17942748
D019772 Topotecan CAMK1 protein affects the susceptibility to Topotecanaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9614514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D055371 Acute Lung Injury nickel sulfate 9.4416100012 12718980 11954676 19131640
MESH:D055371 Acute Lung Injury pirinixic acid 9.4418653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.3016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.3016835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.3217084956
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001260 Ataxia Telangiectasia Quercetin 5.0915336622
MESH:D001321 Autistic Disorder Choline 3.3416818868
MESH:D001327 Autoimmune Diseases Quercetin 4.5119761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms Quercetin 2.1218628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1220435547
MESH:D002105 Cadmium Poisoning Quercetin 5.6816962696
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8816050911 15700767 16011737 10355542 18705752 16227642 16192424 15673190 3786805 15721981 16097048 16124888
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.2118788625
MESH:D006528 Carcinoma, Hepatocellular Quercetin 3.2112508355 19519916
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.0617234771
MESH:D006332 Cardiomegaly Quercetin 6.9419794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.9418670907 18850075 16120746
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.9417110522 16105132 17333356 15861022 11677210 16919318 17681005
MESH:D002779 Cholestasis pirinixic acid 7.9419176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1316354765 8697196 12621046 15668235 15340226
MESH:D003110 Colonic Neoplasms Quercetin 2.4316640504 17191121 19440933 11134977 15741050 19056647 17148506
MESH:D015179 Colorectal Neoplasms Quercetin 2.1818852136 18095365
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 15322242 10048152
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.7716780908 11298694 16823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D002658 Developmental Disabilities Choline 4.7316818868
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.8019496084
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.472869522 19336974 17522070 3732212 4309450 19085960 6884620 16177239 7179309 7440962 21278145 15968718 16227642 9327722 10915739 7120509 15027814 15998439 10092053 3786805 11566570 6623471
MESH:D056486 Drug-Induced Liver Injury cyanoginosin LR 6.4717654400
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004487 Edema pirinixic acid 6.8112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0415322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2812538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.5315959796 61145 16239168 12795759 17595544 19224547 16045604 12631006
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.5315345470
MESH:D005234 Fatty Liver pirinixic acid 13.5320131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis Carbon Tetrachloride 15.4418705752
MESH:D005355 Fibrosis Quercetin 15.4419474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.4420067830
MESH:D005909 Glioblastoma Quercetin 3.4419804834
MESH:D005910 Glioma Quercetin 3.0817643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3710048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6919900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 8.6119772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.6112621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.188697196 16959395 15340226 18606429 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6516899240
MESH:D006943 Hyperglycemia pirinixic acid 9.5020558911
MESH:D006943 Hyperglycemia Quercetin 9.5018262572 11834736
MESH:D006973 Hypertension Quercetin 5.3218356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3218850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1915338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5417937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8912878042 12200463
MESH:D007251 Influenza, Human Quercetin 4.6416624496
MESH:D007333 Insulin Resistance pirinixic acid 2.6816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007627 Keloid Quercetin 5.0617086741
MESH:D007674 Kidney Diseases Quercetin 3.1416962696
MESH:D007938 Leukemia Quercetin 3.1917468513
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8516943688 17157831 11408273 21278145 11903743 16221502 17174718 16239168 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.0117766677 15925388 12667390 18054572 15362042 12632514 17557913 12445418 18339082 18251166 13678700 17805973 12546737 16015684 15876570 18376398 18187930 15730626 17721639 15338365 18279442 16248980 18156304 17708605 18418968 17714472 17640975 14716496 15123356 15673190 18412020 17761835 15818738 15370692 17525996 14512876 16027843 17823541 18395914 12666154 18205269 17698563 12445421 18210741 12898905 12389079 18429990 14620537 10355542 18006644 17944888 16011737 18420326 15996030 12632512 18472094 17869086 15959796 17922224 18263696 16192424 18317297 17976157 14724832 15650968 16136751 16033810 14716833 17631135 18472332 18395095 16097048 12649538 17481882 18166357 18705752 20821823 18277467 15052691 16638106 12609069 15057751 14748882 18481824 12741479 12586293 17565644 17900296 15893842 11481614 16116963 12958196 15931870
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0115474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 5.0112741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0112878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1016246199 17285989 15720792 16964402 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7714706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.9319294768
MESH:D008113 Liver Neoplasms pirinixic acid 10.9320007298 15890375 16377806
MESH:D008113 Liver Neoplasms Quercetin 10.9318980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.9316984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.1412014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Quercetin 10.1419519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.1412151625
MESH:D008175 Lung Neoplasms Quercetin 2.4316280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4319555203 11884234
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009203 Myocardial Infarction pirinixic acid 5.8319151258
MESH:D009203 Myocardial Infarction Quercetin 5.8319595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.6516411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 8.6519207477
MESH:D009369 Neoplasms pirinixic acid 5.1817405874
MESH:D009369 Neoplasms Quercetin 5.1815185748
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D009447 Neuroblastoma Topotecan 3.8915176712
MESH:D020078 Neurogenic Inflammation Quercetin 4.4517929310
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.3119495926
MESH:D010051 Ovarian Neoplasms Quercetin 2.7519005980
MESH:D010190 Pancreatic Neoplasms Quercetin 2.8716965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Quercetin 4.0519056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111222880 11118676 11399792 11896295
MESH:D011471 Prostatic Neoplasms Quercetin 3.5914715546 17292933
MESH:D011537 Pruritus Ethinyl Estradiol 3.4315861022 16919318
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012554 Schistosomiasis japonica Quercetin 5.6816862918
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D001749 Urinary Bladder Neoplasms Quercetin 2.8316720314
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26048
    • Releated gene ID Related gene Name
    PA134CYP11B2
    No data
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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