AutismKB 2.0

Annotation Detail for SYDE1


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Basic Information Top
Gene Symbol:SYDE1 ( 7h3,FLJ13511 )
Gene Full Name: synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
Band: 19p13.12
Quick LinksEntrez ID:85360; OMIM: NA; Uniprot ID:SYDE1_HUMAN; ENSEMBL ID: ENSG00000105137; HGNC ID: 25824
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Signaling by Rho GTPases
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SYDE1 mRNAaffects expression 17562736
D001104 Arbutin Arbutin results in decreased expression of SYDE1 mRNAdecreases expression 17103032
D002117 Calcitriol Calcitriol results in increased expression of SYDE1 mRNAincreases expression 16002434
D004317 Doxorubicin SYDE1 protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
C025462 sulindac sulfide sulindac sulfide results in increased expression of SYDE1 mRNAincreases expression 12734198
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SYDE1 mRNAincreases expression 19465110
D014747 Vinblastine SYDE1 protein affects the susceptibility to Vinblastineaffects response to substance 16217747
D014810 Vitamin E Vitamin E results in increased expression of SYDE1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1814514962 15322242 11752688
MESH:D000230 Adenocarcinoma Doxorubicin 2.6117418594
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000419 Albuminuria Doxorubicin 4.8321441931
MESH:D000544 Alzheimer Disease sulindac sulfide 3.1318759972
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.0814601052
MESH:D001932 Brain Neoplasms Doxorubicin 4.0417150277
MESH:D001943 Breast Neoplasms Calcitriol 1.9311237771
MESH:D001943 Breast Neoplasms Doxorubicin 1.9315939500 11325840 18234424 17426702 16096432 15567936 19526202 16115903 18628466 15136595 18695136 15668708 16322301 15692762 18382427 17369602 15994142 16595493 17983394 16264153 15634643 16935488 15993339 16826403
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9320435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.2416050911
MESH:D002276 Carcinoid Tumor Doxorubicin 5.1916051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.083084413
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 3.0817876044 16023760 16234567 18059187
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.5112391285
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 7.2816201981 1485588
MESH:D002292 Carcinoma, Renal Cell Vinblastine 7.281485588
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 5.1011237771
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 5.106189445
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918670907 16120746 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.6817382496 16455267 15792986 17308081 16952015 16731534 16242529 15505089 17924179 16109756 18627295 16269455 16278810 17329180 15811867 17007740 17974986 16612575 17928571 17519947 17351982 15476868 16651473 17131338 16364871
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0116243910 17334414
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1916354765 12621046 8697196 15340226 15668235
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.9818802399 18259882
MESH:D015179 Colorectal Neoplasms Vinblastine 2.9818802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5410048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5419769572
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5319416960 11743745 10774834 17906064 16227642 10915739 11834606 11739529 19085960 12153990 16781746 10663392 14725611 18071297 17522070 19370779 15619225 18713872 12958197 14550746 19420014 12705907 19923254 17562736 11421492 12540782 19164858 11287661 19739265 16485898 12392966 11529661 14986274 16393943 16081117 16177239 12594235 2444490 11461765 16109766 15968718
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 6.5317416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004362 Drug Toxicity Doxorubicin 8.7018602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.7011462148
MESH:C538011 Eales disease Vitamin E 5.089068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2818230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.2115138306
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.6017359293
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.259294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.5318037988
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.9319069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2520067830
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005909 Glioblastoma Doxorubicin 3.4917150277
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.6815692506
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9510048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.9516080930
MESH:D006331 Heart Diseases Doxorubicin 3.6416144979 17888722 14766674 16244371 18674790 16495754 16244372 16707910 16879835 17875725 18006777 16330681 12587719
MESH:D006333 Heart Failure Doxorubicin 3.4817481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.1415692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2016120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7716863852 16490937
MESH:D006689 Hodgkin Disease Doxorubicin 8.5218501091 15147373 17606976
MESH:D006689 Hodgkin Disease Vinblastine 8.5218180244 18501091
MESH:D019584 Hot Flashes Vitamin E 4.3514716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4218606429 16959395 8697196 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9612200463 12878042
MESH:D007251 Influenza, Human Vitamin E 4.5916624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007674 Kidney Diseases Acetaminophen 10.8515629191 12587719
MESH:D007674 Kidney Diseases Doxorubicin 10.8515699352 15369732 16775033
MESH:D007674 Kidney Diseases Vitamin E 10.8512488133
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.4016707910
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.5316085563
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.6416439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6412878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.6416169303
MESH:D008107 Liver Diseases Acetaminophen 1.6711587558 16611625 12587719 19460945 16610002 12969438 19014921 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7916984957
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 6.3817085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.3812151625
MESH:D008171 Lung Diseases Vitamin E 3.3316863852
MESH:D008175 Lung Neoplasms Doxorubicin 3.576189445 17418594
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5711884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 3.5711062179
MESH:D008223 Lymphoma Doxorubicin 3.6316098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.9917654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.8715621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.1715458769
MESH:D008545 Melanoma Doxorubicin 3.9016827129
MESH:D008545 Melanoma Vinblastine 3.9016809738 17761969 18176117 16248763 12374674 15577323 18332650 16432458 18505091 15577320
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008654 Mesothelioma Doxorubicin 3.1417638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.7415792986
MESH:D052016 Mucositis Doxorubicin 5.1317415656
MESH:D009203 Myocardial Infarction Doxorubicin 3.0315857846 19429709
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0318259882
MESH:D009401 Nephrosis Doxorubicin 5.0816636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.2115640375 16889571
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009447 Neuroblastoma Doxorubicin 3.3715555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009503 Neutropenia Vinblastine 4.8317378895
MESH:D012516 Osteosarcoma Doxorubicin 4.3115930896
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.5317983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.5317638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311896295 11222880 11118676 11399792
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.1215572423
MESH:D011471 Prostatic Neoplasms Calcitriol 2.6216289102 15754350 18247401 16644109 12479363
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.6216888761 15897917 16868541 16729912 15749863 18437689
MESH:D011471 Prostatic Neoplasms Vitamin E 2.6215084515
MESH:D051437 Renal Insufficiency Doxorubicin 4.5317922066
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012509 Sarcoma Doxorubicin 4.2217710206 15625365 17203757 16767912 15675481 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.5216326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.1317846226
MESH:D012871 Skin Diseases Vitamin E 2.4918709164
MESH:D012878 Skin Neoplasms Doxorubicin 6.0215692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0216192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.8716767912 17203757 15625365
MESH:D020521 Stroke Vitamin E 3.7116517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.5517909728 16010429
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 2.8417653716
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014594 Uterine Neoplasms sulindac sulfide 4.9318645019
MESH:D014625 Vaginal Neoplasms Vinblastine 5.3515577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.5317678736 16364871 17334414 17638931
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
Pathway ID Pathway Name
REACT:11044 Signaling by Rho GTPases
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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