AutismKB 2.0

Annotation Detail for PIR


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PIR ( - )
Gene Full Name: pirin (iron-binding nuclear protein)
Band: Xp22.2
Quick LinksEntrez ID:8544; OMIM: 603329; Uniprot ID:PIR_HUMAN; ENSEMBL ID: ENSG00000087842; HGNC ID: 30048
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PIR mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PIR mRNAaffects expression 21346803
C035208 2-amino-4,6-dinitrotoluene 2-amino-4,6-dinitrotoluene affects the expression of PIR mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of PIR mRNAdecreases expression 16788091
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of PIR mRNAaffects expression 21346803
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in increased expression of PIR mRNAincreases expression 15982314
C029728 4-phenylenediamine 4-phenylenediamine results in increased expression of PIR mRNAincreases expression 16314067
D000082 Acetaminophen Acetaminophen affects the expression of PIR mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of PIR proteinaffects expression 20106945
C103303 alitretinoin alitretinoin results in increased expression of PIR mRNAincreases expression 15982314
C006632 arsenic trioxide arsenic trioxide results in increased expression of PIR mRNAincreases expression 15761015
19417148
C015001 arsenite arsenite results in increased expression of PIR mRNAincreases expression 18929588
C015001 arsenite TRP53 protein affects the reaction [arsenite results in increased expression of PIR mRNA]affects reaction|increases expression 18929588
D003474 Curcumin Curcumin results in increased expression of PIR mRNAincreases expression 18299980
D004041 Dietary Fats Dietary Fats results in decreased expression of PIR mRNAdecreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of PIR mRNAincreases expression 19638242
D004137 Dinitrochlorobenzene Dinitrochlorobenzene results in increased expression of PIR mRNAincreases expression 16314067
D004317 Doxorubicin PIR protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D005472 Fluorouracil Fluorouracil results in decreased expression of PIR proteindecreases expression 15352031
D005472 Fluorouracil PIR protein affects the susceptibility to Fluorouracilaffects response to substance 15352031
D017313 Fenretinide Fenretinide results in increased expression of PIR mRNAincreases expression 16671099
D007529 Isoflavones Isoflavones results in increased expression of PIR mRNAincreases expression 17374662
D016685 Mitomycin PIR protein affects the susceptibility to Mitomycinaffects response to substance 16217747
C001478 N(6)-(delta(2)-isopentenyl)adenine N(6)-(delta(2)-isopentenyl)adenine results in increased expression of PIR mRNAincreases expression 16129123
C029938 nickel sulfate nickel sulfate results in increased expression of PIR mRNAincreases expression 16314067
C041786 palm oil palm oil results in decreased expression of PIR mRNAdecreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of PIR mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of PIR mRNAincreases expression 19482888
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PIR mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PIR mRNAaffects binding|decreases expression|increases activity 19710929
D015474 Isotretinoin Isotretinoin results in increased expression of PIR mRNAincreases expression 15982314
D012402 Rotenone Rotenone results in decreased expression of PIR mRNAdecreases expression 19013527
C515055 S-(dimethylarsino)-glutathione S-(dimethylarsino)-glutathione results in increased expression of PIR mRNAincreases expression 19417148
D014212 Tretinoin Tretinoin metabolite results in increased expression of PIR mRNAincreases expression 15982314
D014212 Tretinoin Tretinoin results in increased expression of PIR mRNAincreases expression 15982314
D014303 Trinitrotoluene Trinitrotoluene affects the expression of PIR mRNAaffects expression 21346803
D014747 Vinblastine PIR protein affects the susceptibility to Vinblastineaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 2-amino-4,6-dinitrotoluene 23.427525203
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 23.427525203
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 23.4218769834
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 23.426195326
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 23.427525203
MESH:D000015 Abnormalities, Multiple Isotretinoin 4.7018769834
MESH:D017486 Acneiform Eruptions Isotretinoin 5.9716232082
MESH:D000152 Acne Vulgaris Isotretinoin 5.1618769834 16185265
MESH:D055371 Acute Lung Injury nickel sulfate 8.1919131640 16100012 11954676 12718980
MESH:D055371 Acute Lung Injury pirinixic acid 8.1918653653
MESH:D000230 Adenocarcinoma arsenic trioxide 9.5511798837 19825857
MESH:D000230 Adenocarcinoma Doxorubicin 9.5517418594
MESH:D000230 Adenocarcinoma Fenretinide 9.5510697514
MESH:D000230 Adenocarcinoma Fluorouracil 9.5517638652
MESH:D000236 Adenoma Diethylnitrosamine 2.6710737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 15.5516434500 19061943 17162532 17620307 18056438 19052882
MESH:D018248 Adenoma, Liver Cell Phenobarbital 15.5517620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.5516434500
MESH:D000419 Albuminuria Doxorubicin 4.2521441931
MESH:D019973 Alcohol-Related Disorders Curcumin 4.7717887948
MESH:D000505 Alopecia Isoflavones 8.7717569567
MESH:D000505 Alopecia Tretinoin 8.7715955085
MESH:D000544 Alzheimer Disease Curcumin 2.5515590663
MESH:D000740 Anemia Fluorouracil 3.4516511603 15504547 17963324
MESH:D000799 Angioedema Acetaminophen 3.5310982225
MESH:D001161 Arteriosclerosis Dietary Fats 3.5915238619
MESH:D001169 Arthritis, Experimental Tretinoin 2.8916412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.4716807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.4716292516
MESH:D001249 Asthma Tretinoin 2.2516456186
MESH:D050197 Atherosclerosis Curcumin 3.1418704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4518445737
MESH:D001327 Autoimmune Diseases Curcumin 4.1919761891
MESH:D001471 Barrett Esophagus Tretinoin 4.1116935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 13.7516206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.7519483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.7516206674 16197459
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.3814601052
MESH:D002545 Brain Ischemia Curcumin 4.0216770732
MESH:D001932 Brain Neoplasms Curcumin 13.2417596214
MESH:D001932 Brain Neoplasms Doxorubicin 13.2417150277
MESH:D001932 Brain Neoplasms Fenretinide 13.2416187019
MESH:D001943 Breast Neoplasms alitretinoin 4.4616344269
MESH:D001943 Breast Neoplasms Curcumin 4.4618462866 16243823 18593918 19250217
MESH:D001943 Breast Neoplasms Dietary Fats 4.4620435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.4617474063
MESH:D001943 Breast Neoplasms Doxorubicin 4.4616264153 16595493 16096432 15567936 18695136 18382427 18628466 15634643 19526202 16826403 18234424 15668708 15939500 17369602 15136595 16935488 17426702 16115903 16322301 17983394 15993339 15994142 11325840 15692762
MESH:D001943 Breast Neoplasms Fenretinide 4.4616601279
MESH:D001943 Breast Neoplasms Fluorouracil 4.4618357371 18608205 16110121 15136595 19217205 16595493 16557594
MESH:D001943 Breast Neoplasms Tretinoin 4.4616873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2816813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.0411589617
MESH:D002276 Carcinoid Tumor Doxorubicin 11.3016051944
MESH:D002276 Carcinoid Tumor Fluorouracil 11.3016051944
MESH:D002277 Carcinoma Curcumin 7.7618593918
MESH:D002277 Carcinoma Fluorouracil 7.7617121937
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8416168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 24.8716705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 24.8716705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 24.873084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 24.8721507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 24.8711135700 16217749 15553829 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 24.8716502159 16830150 10737359 17173139 20101231 16779866 20514400 20007298 16569478 19822196 17055752 19335982 19383236 3581430 19539802 18978308 20727157 11831363 19052882 16807293 19919837 18056438 10672840 18506893 3084413 16698587 20512989 17428255 18788625 18494052 19418558 16288022 16935385 20432363 20214788 19171122 19701751 20524982 19107877 16681979 19208518 21159647 18393292 19394651 18665156 20084675 18210153 16540662 16878318 17138121 18971187 17761372 16328049 19519916 17162532 20935162 17978847 18691550 18785209
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 24.8718059187 16023760 17876044 16234567
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 24.8716270382 17159502
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 24.8716332177 18930000 17088986 16799960 17045692 17971768
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 24.8720007298 1701930 17173139 6705139 20935162
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 24.871917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.8718414057
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.5619014326
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 10.0716201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 10.0718695887
MESH:D002292 Carcinoma, Renal Cell Vinblastine 10.071485588
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8512490120
MESH:D002294 Carcinoma, Squamous Cell Curcumin 16.8418462866
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 16.846189445
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 16.8416274795
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 16.8416757204 17066447 16280240 18986760
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 16.8411237771
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 16.8416051514 16096774
MESH:D009202 Cardiomyopathies Doxorubicin 3.3316364871 17924179 17519947 15811867 17329180 16278810 15476868 16952015 17308081 17974986 16455267 16269455 16731534 17351982 17131338 18627295 16651473 15792986 16242529 17007740 17382496 16612575 17928571 16109756 15505089
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8416243910 17334414
MESH:D002318 Cardiovascular Diseases Isoflavones 3.9417689850
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 16.2014694615
MESH:D002386 Cataract Acetaminophen 16.2010977129
MESH:D002386 Cataract Tretinoin 16.2017460283
MESH:D002386 Cataract Trinitrotoluene 16.2015817613 14694615
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 5.996135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 5.997505956 17174075 21159647 2727394
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.954080065
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 11.9416154183
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 11.9416129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.4319052882
MESH:D002779 Cholestasis pirinixic acid 2.6019176532
MESH:D002822 Choriocarcinoma Tretinoin 4.8416461808
MESH:D002972 Cleft Palate Tretinoin 2.549407595
MESH:D003092 Colitis Curcumin 8.6316804969 18200517 16782535
MESH:D003092 Colitis Tretinoin 8.6317035595
MESH:D003093 Colitis, Ulcerative Dinitrochlorobenzene 3.7517373747 19159591
MESH:D003103 Coloboma Curcumin 4.2718809619
MESH:D003110 Colonic Neoplasms arsenite 5.5715037631
MESH:D003110 Colonic Neoplasms Curcumin 5.5716340194 19359593
MESH:D003110 Colonic Neoplasms Fluorouracil 5.5717725105 17172411 18772588 17169374 16510598 17018589 15001691 17016597 16340194 17287894
MESH:D015179 Colorectal Neoplasms arsenic trioxide 7.9620501625
MESH:D015179 Colorectal Neoplasms Doxorubicin 7.9618802399 18259882
MESH:D015179 Colorectal Neoplasms Fenretinide 7.9617273769
MESH:D015179 Colorectal Neoplasms Fluorouracil 7.9618949393 16524972 17401013 18383874 18288408 18802399 16303861 16331619 17016601 16282729 17094418 20501625 15289873 17695437 17454858 17255274 14970324 15148649 17594712 16391804 18509181 18448328
MESH:D015179 Colorectal Neoplasms Isoflavones 7.9617116718
MESH:D015179 Colorectal Neoplasms Vinblastine 7.9618802399
MESH:D000013 Congenital Abnormalities 2-amino-4,6-dinitrotoluene 14.3915095906
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 14.3915095906
MESH:D000013 Congenital Abnormalities Trinitrotoluene 14.3915095906
MESH:D016510 Corneal Neovascularization Curcumin 4.5918497527
MESH:D023903 Coronary Restenosis arsenic trioxide 3.8912609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.7810525206
MESH:D019465 Craniofacial Abnormalities Isotretinoin 3.789879862 18769834
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.789211117 9125849 9142499 14991402 9224671 9664655 16925845 10589399 8800419 17551590
MESH:D003490 Cyanosis 2,4-dinitrotoluene 17.0418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 17.0418551238
MESH:D003490 Cyanosis Trinitrotoluene 17.0418551238
MESH:D007644 Darier Disease Fluorouracil 4.4816733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.8115213294
MESH:D017449 Dermatitis, Allergic Contact 4-phenylenediamine 10.2919470301 11298694 16823706 18759875 11906362 16533241
MESH:D017449 Dermatitis, Allergic Contact Dinitrochlorobenzene 10.2915491423
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 10.2916823706 11298694 16780908
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2818249437
MESH:D003877 Dermatitis, Contact 4-phenylenediamine 5.0511531941
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.3318403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3320387270
MESH:D003928 Diabetic Nephropathies Curcumin 3.7518204486
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 20.5118551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 20.5118551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2-amino-4,6-dinitrotoluene 20.5121346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 20.5121346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 20.5110663392 16227642 12594235 12958197 14725611 15619225 12153990 16081117 12540782 19085960 11743745 12392966 14550746 11834606 19164858 15968718 12705907 19739265 19416960 17906064 16393943 16177239 18713872 11421492 11739529 14986274 16485898 16109766 11529661 11287661 17562736 19420014 11461765 10915739 19370779 17522070 19923254 2444490 18071297 10774834 16781746
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 20.5119107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 20.5117416283
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 20.5118551238 21346803
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7819426721
MESH:D004362 Drug Toxicity Doxorubicin 3.4418602426
MESH:D004381 Duodenal Ulcer Curcumin 3.7617351913
MESH:D050171 Dyslipidemias Dietary Fats 3.2318367378
MESH:D004421 Dystonia Phenobarbital 3.721851702
MESH:D004487 Edema pirinixic acid 2.2212083418
MESH:D004489 Edema, Cardiac Tretinoin 4.1518230668
MESH:D016889 Endometrial Neoplasms Doxorubicin 6.9117359293
MESH:D016889 Endometrial Neoplasms Tretinoin 6.9116569247
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.8418037988
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.803659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.563922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.7320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.286401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.957750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.713659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8016302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.3112903497
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.3116481741 17638652 16785472 16337965 15173087
MESH:D005124 Eye Abnormalities Tretinoin 3.359664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 27.1215073043
MESH:D005234 Fatty Liver arsenite 27.1218296743
MESH:D005234 Fatty Liver Curcumin 27.1219297423
MESH:D005234 Fatty Liver Dietary Fats 27.1218296743 19004024 17967931 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 27.1221071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 27.1219236843 20131406
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.2819069698
MESH:D005355 Fibrosis arsenite 18.7318296743
MESH:D005355 Fibrosis Curcumin 18.7318705752
MESH:D005355 Fibrosis Dietary Fats 18.7318296743
MESH:D005355 Fibrosis Tretinoin 18.7317994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.9716904648
MESH:D005756 Gastritis Acetaminophen 3.3616983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.3918462866
MESH:D005909 Glioblastoma Curcumin 15.3517596214
MESH:D005909 Glioblastoma Doxorubicin 15.3517150277
MESH:D005909 Glioblastoma Fenretinide 15.3516187019
MESH:D005909 Glioblastoma Tretinoin 15.3517312396
MESH:D005910 Glioma Fluorouracil 2.7416145905
MESH:D006258 Head and Neck Neoplasms Curcumin 16.7618829502 18462866
MESH:D006258 Head and Neck Neoplasms Doxorubicin 16.7615692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 16.7615162350 15102660 18337622
MESH:D006258 Head and Neck Neoplasms Tretinoin 16.7616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8416084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.739664655 14991402
MESH:D006331 Heart Diseases Doxorubicin 3.2716244372 16144979 18674790 16495754 16244371 12587719 16879835 16330681 14766674 17888722 17875725 16707910 18006777
MESH:D006333 Heart Failure Doxorubicin 6.4117481944
MESH:D006333 Heart Failure pirinixic acid 6.4120558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.6315692506
MESH:D006529 Hepatomegaly Phenobarbital 12.8016109766
MESH:D006529 Hepatomegaly pirinixic acid 12.8016221962 19772884 18467677 19176532
MESH:D006529 Hepatomegaly Trinitrotoluene 12.8015817613
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.7417701891
MESH:D006689 Hodgkin Disease Doxorubicin 6.9515147373 18501091 17606976
MESH:D006689 Hodgkin Disease Vinblastine 6.9518180244 18501091
MESH:D019584 Hot Flashes Isoflavones 4.6714716179 17290160
MESH:D006930 Hyperalgesia Acetaminophen 6.8216870215
MESH:D006930 Hyperalgesia Tretinoin 6.8216870215
MESH:D006937 Hypercholesterolemia Curcumin 8.3118704882
MESH:D006937 Hypercholesterolemia Dietary Fats 8.3121332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2616778211
MESH:D006943 Hyperglycemia pirinixic acid 2.9220558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.3321332399
MESH:D007248 Infertility, Male Trinitrotoluene 3.4712150543
MESH:D007249 Inflammation Curcumin 7.4717151092 18403477 16956363
MESH:D007249 Inflammation Dietary Fats 7.4720412841
MESH:D007249 Inflammation Diethylnitrosamine 7.4718785209
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.0818596194 18200517
MESH:D007333 Insulin Resistance Dietary Fats 6.5711836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 6.5716306350
MESH:D007410 Intestinal Diseases Tretinoin 3.4617994277
MESH:D007414 Intestinal Neoplasms Curcumin 3.9510783313
MESH:D007569 Jaw Abnormalities Tretinoin 3.6215992940 17551590
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.3316144296
MESH:D007674 Kidney Diseases Acetaminophen 5.4615629191 12587719
MESH:D007674 Kidney Diseases Doxorubicin 5.4616775033 15369732 15699352
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.8816707910
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.0016705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.0016705839
MESH:D007680 Kidney Neoplasms Fluorouracil 11.0016985049
MESH:D007889 Leiomyoma Curcumin 4.2818555241
MESH:D007938 Leukemia arsenic trioxide 9.6115070760
MESH:D007938 Leukemia Curcumin 9.6118462866
MESH:D007938 Leukemia Tretinoin 9.6117143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.8416085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 8.8412560223 17077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 8.8416106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.0016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.5519077051
MESH:D007951 Leukemia, Myeloid Tretinoin 8.5516932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.6717050201 16467208 19850784 16968895 20471514
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.6719850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 6.9615622746 17649720 11161223 17107899 16331271 15213294 15748426 16823087 16966277 11468182 19225113 19642359 15336539 17712046 12679006 19035177 17217047 16112521 12018890 12712474 19075265 16891316 17869043 16330433 9834237
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 6.9616935935 17339181 17506722 17712046 17217047 9834237 17294898 19075265 12679006 17107899 17301526 19035177 15748426 19642359 19225113 16788101 16140955 17649720 16331271 17361223 17368321 16891316 16823087 16766008 19029980
MESH:D015458 Leukemia, T-Cell arsenic trioxide 10.7316882451
MESH:D015458 Leukemia, T-Cell Curcumin 10.7316106398
MESH:D007972 Leukoplakia, Oral Fenretinide 5.7316707609
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.099224671
MESH:D008103 Liver Cirrhosis arsenite 14.3718296743
MESH:D008103 Liver Cirrhosis Dietary Fats 14.3718296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 14.3718665156 19638242 20032147 18522880 18407596
MESH:D008103 Liver Cirrhosis Phenobarbital 14.3721047994
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 4.6518006644 18705752 17355460
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 4.6516595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.6515474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.6516248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 8.6711587558 12969438 19014921 19460945 16611625 19784758 16610002 12587719
MESH:D008107 Liver Diseases Curcumin 8.6716956363
MESH:D008107 Liver Diseases Diethylnitrosamine 8.6717034775
MESH:D008107 Liver Diseases Phenobarbital 8.6719363144
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9716871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 23.817678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 23.812125692 9163691 18177683 15890375
MESH:D008113 Liver Neoplasms arsenic trioxide 23.8114682389
MESH:D008113 Liver Neoplasms Diethylnitrosamine 23.8120434301 19812893 19690152 19073162 18977376 10737359 19850985 21167192 19294768 20452335 18754104 12112319 18978307 19499222 19551842 15885732 20501860 19427195 18644402 19996281 20118626 21071580 19426721 2862719 19254457 9163691 2422723 20405173 15175105 21047994 19090486 16942905 18648771 20137499 20101389 20583210 19255062 19256749 20492335 19833225 21278145 12771043 19638242 19642983
MESH:D008113 Liver Neoplasms Fluorouracil 23.8118383874 15113037 16603448 17045692
MESH:D008113 Liver Neoplasms Mitomycin 23.8115113037
MESH:D008113 Liver Neoplasms Phenobarbital 23.818742319 15975961 19482888 19812893 19073162 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 23.8120007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 20.852876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 20.858603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 20.8520377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 20.8517942915 17174075 18282651 16267830 16842330 17854601 18544905 19539802 3124819 18775883 18093689 2563599 18079962 19009564 19126423 21159647 18253720 19519916 19004024 18308698 9362446 18164116
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 20.8517085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 20.852563599 18308698 17172636 6150874 1399818
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1215213294
MESH:D008175 Lung Neoplasms Aflatoxin B1 14.5714755239
MESH:D008175 Lung Neoplasms alitretinoin 14.5716413115
MESH:D008175 Lung Neoplasms arsenic trioxide 14.5719825857 11798837
MESH:D008175 Lung Neoplasms arsenite 14.5716809336
MESH:D008175 Lung Neoplasms Curcumin 14.5719359593 16243823 18462866
MESH:D008175 Lung Neoplasms Diethylnitrosamine 14.5721163286 20970405 6695378 20512841
MESH:D008175 Lung Neoplasms Doxorubicin 14.576189445 17418594
MESH:D008175 Lung Neoplasms Fluorouracil 14.5715246190
MESH:D008175 Lung Neoplasms Isotretinoin 14.5715899809
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.4815086387
MESH:D008223 Lymphoma Curcumin 7.0618462866
MESH:D008223 Lymphoma Doxorubicin 7.0616098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.5417654614
MESH:D016399 Lymphoma, T-Cell Curcumin 10.5516173963
MESH:D016399 Lymphoma, T-Cell Doxorubicin 10.5515621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 5.8315458769
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 5.8310697514
MESH:D008527 Medulloblastoma Tretinoin 2.6617453147
MESH:D008545 Melanoma Curcumin 14.4817885582 18462866
MESH:D008545 Melanoma Dinitrochlorobenzene 14.4812202904 17334785
MESH:D008545 Melanoma Doxorubicin 14.4816827129
MESH:D008545 Melanoma Fenretinide 14.4816270382
MESH:D008545 Melanoma Isotretinoin 14.4817237267
MESH:D008545 Melanoma Tretinoin 14.4816752155
MESH:D008545 Melanoma Vinblastine 14.4818332650 16432458 16248763 15577320 12374674 16809738 17761969 18176117 15577323 18505091
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2619513568
MESH:D008569 Memory Disorders Curcumin 3.8617263510
MESH:D008591 Meningomyelocele Tretinoin 4.1216940565
MESH:D008654 Mesothelioma Doxorubicin 2.9317638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.2215792986
MESH:D009062 Mouth Neoplasms Fenretinide 8.1616274795
MESH:D009062 Mouth Neoplasms Fluorouracil 8.1618986760 16757204
MESH:D052016 Mucositis Doxorubicin 4.4817415656
MESH:D009101 Multiple Myeloma arsenic trioxide 11.1415949261 19417148 14977855 11468182 19549372
MESH:D009101 Multiple Myeloma Curcumin 11.1419372569
MESH:D009101 Multiple Myeloma S-(dimethylarsino)-glutathione 11.1419417148
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.6117962980
MESH:D009135 Muscular Diseases pirinixic acid 3.2016239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.3618349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.8016105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.8017596541
MESH:D009203 Myocardial Infarction Doxorubicin 5.2715857846 19429709
MESH:D009203 Myocardial Infarction pirinixic acid 5.2719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7116411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.1617484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 15.9818551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 15.987678174 18551238
MESH:D009336 Necrosis Trinitrotoluene 15.9818551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 9.3416624393
MESH:D009361 Neoplasm Invasiveness Curcumin 9.3418495463
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.453581430 9029167
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.4518259882
MESH:D009369 Neoplasms alitretinoin 14.0916946489
MESH:D009369 Neoplasms Fenretinide 14.0917353921 15958647
MESH:D009369 Neoplasms Fluorouracil 14.0916928823 18239605 18600527
MESH:D009369 Neoplasms pirinixic acid 14.0917405874
MESH:D009369 Neoplasms Tretinoin 14.0916946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.2212497104
MESH:D009389 Neovascularization, Pathologic arsenite 4.1015738583
MESH:D009401 Nephrosis Doxorubicin 4.4616636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.7415640375 16889571
MESH:D009410 Nerve Degeneration Rotenone 3.6515790535 18619942 17356569
MESH:D009421 Nervous System Malformations Tretinoin 3.489125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.3118462866
MESH:D009436 Neural Tube Defects arsenic trioxide 6.6310525206
MESH:D009436 Neural Tube Defects Tretinoin 6.639142499
MESH:D009447 Neuroblastoma Doxorubicin 6.8215555623
MESH:D009447 Neuroblastoma Isotretinoin 6.8217368321
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.3518514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.3520387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8020387270
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.3716303764
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2316436463
MESH:D009503 Neutropenia Vinblastine 4.2917378895
MESH:D009765 Obesity Curcumin 6.9419297423
MESH:D009765 Obesity Dietary Fats 6.9421332399 11836018 18674790 18457598 20518802 16723640 19632207 20132043 17217161
MESH:D009765 Obesity pirinixic acid 6.9420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 19.4312819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 19.4316049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 19.4314694615
MESH:D009784 Occupational Diseases Trinitrotoluene 19.4312819281 14694615 17852074
MESH:D010018 Osteomalacia Phenobarbital 4.0517016548
MESH:D010024 Osteoporosis Curcumin 7.0418719352
MESH:D010024 Osteoporosis Isoflavones 7.0416562857
MESH:D012516 Osteosarcoma Doxorubicin 3.8715930896
MESH:D010051 Ovarian Neoplasms arsenic trioxide 10.5016624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Curcumin 10.5019020741 18462866
MESH:D010051 Ovarian Neoplasms Fenretinide 10.5016133793
MESH:D010051 Ovarian Neoplasms Tretinoin 10.5016936753
MESH:D010146 Pain Acetaminophen 5.7716870215
MESH:D010146 Pain Tretinoin 5.7716870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 27.3515580305
MESH:D010190 Pancreatic Neoplasms Curcumin 27.3519401701 17440100 19196508
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 27.3516540662
MESH:D010190 Pancreatic Neoplasms Fenretinide 27.3515580305
MESH:D010190 Pancreatic Neoplasms Fluorouracil 27.3516929163 16500647 19003803 15113037
MESH:D010190 Pancreatic Neoplasms Mitomycin 27.3515113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 27.3516965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 27.3515976015
MESH:D010235 Paraganglioma arsenic trioxide 3.8819927285
MESH:D010300 Parkinson Disease Rotenone 2.8615451049 19232380 16140633 11445065 19114014 18191903 16412576 18619942 11535288
MESH:D020734 Parkinsonian Disorders Rotenone 3.8115927086 18197244 15795934 15574749
MESH:D003557 Phyllodes Tumor Doxorubicin 4.8417983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.8417638057
MESH:D017499 Porokeratosis alitretinoin 5.6916144296
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.232563599
MESH:D011230 Precancerous Conditions Phenobarbital 8.232563599
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 4.5718769834
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.8919131511
MESH:D011471 Prostatic Neoplasms Curcumin 1.8918226269 11398177 18769126 18156803 12497104 15129424 10851300
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.8915749863 15897917 16729912 16888761 18437689 16868541
MESH:D011471 Prostatic Neoplasms Fenretinide 1.8917024972
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8918626508 19082440
MESH:D011471 Prostatic Neoplasms Isoflavones 1.8917219775 17374662 17571952 16365062
MESH:D011507 Proteinuria Tretinoin 3.3216636307
MESH:D019310 Pseudolymphoma Phenobarbital 4.1812752131
MESH:D011596 Psychomotor Disorders Isotretinoin 5.6118769834
MESH:D011625 Pterygium Tretinoin 4.4816723453
MESH:D011656 Pulmonary Emphysema Curcumin 4.2619168576
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7515538739 18722050 16160472 18286688
MESH:D051437 Renal Insufficiency Doxorubicin 3.9217922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.2319058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.7418379247 10666014
MESH:D012162 Retinal Degeneration Fenretinide 4.1716303925
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8116283617 16116481
MESH:D012509 Sarcoma Curcumin 8.6818462866
MESH:D012509 Sarcoma Doxorubicin 8.6816767912 18313854 17710206 17203757 15625365 15675481
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 9.3016646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 9.3016326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.4817846226
MESH:D012640 Seizures 2,4-dinitrotoluene 12.3818551238
MESH:D012640 Seizures 2,6-dinitrotoluene 12.3818551238
MESH:D012640 Seizures Phenobarbital 12.383137016 11442880 4039156 16876388
MESH:D012640 Seizures Trinitrotoluene 12.3818551238
MESH:D003294 Seizures, Febrile Phenobarbital 4.516407741
MESH:D018805 Sepsis Curcumin 3.8218389075
MESH:D012878 Skin Neoplasms Doxorubicin 8.7915692506
MESH:D012878 Skin Neoplasms Fenretinide 8.7916467112
MESH:D012878 Skin Neoplasms Tretinoin 8.7916467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.2616767912 17203757 15625365
MESH:D013163 Splenomegaly Trinitrotoluene 4.9015817613
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.4517007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.4518456281
MESH:D013274 Stomach Neoplasms Fluorouracil 4.4517522103 18567086 19015929 18396642 19084572 16424979 17498489 15786421 16951190 17172411
MESH:D013274 Stomach Neoplasms Tretinoin 4.4517261132
MESH:D013276 Stomach Ulcer Curcumin 3.2319188055 16631530
MESH:D013964 Thyroid Neoplasms arsenic trioxide 19.9919014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 19.997505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 19.9916010429 17909728
MESH:D013964 Thyroid Neoplasms Phenobarbital 19.991399818
MESH:D013964 Thyroid Neoplasms Tretinoin 19.9916026305 17045167
MESH:D014062 Tongue Neoplasms Fluorouracil 8.9416280240
MESH:D014062 Tongue Neoplasms Tretinoin 8.9416051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.6515213294
MESH:D014376 Tuberculosis Tretinoin 3.0416040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 18.2516049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 18.2516049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 18.2511780464 20435036 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms Curcumin 18.2518593936
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 18.2517653716
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 18.2516720286
MESH:D014565 Urogenital Neoplasms Curcumin 4.9518462866
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.9510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.9510091137
MESH:D014581 Urticaria Acetaminophen 2.6910982225
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 14.4216154183
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 14.4216803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 14.4216129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.2916752155
MESH:D014625 Vaginal Neoplasms Vinblastine 4.7415577323
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.9217334414 16364871 17678736 17638931
MESH:D014820 Vitiligo Tretinoin 3.7616761959
MESH:D015430 Weight Gain Dietary Fats 3.4816723640
MESH:D009396 Wilms Tumor Tretinoin 3.7116287080
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved