AutismKB 2.0

Annotation Detail for SSH2


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Basic Information Top
Gene Symbol:SSH2 ( KIAA1725,MGC78588,SSH-2 )
Gene Full Name: slingshot homolog 2 (Drosophila)
Band: 17q11.2
Quick LinksEntrez ID:85464; OMIM: 606779; Uniprot ID:SSH2_HUMAN; ENSEMBL ID: ENSG00000141298; HGNC ID: 30580
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04810Regulation of actin cytoskeleton
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SSH2 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of SSH2 mRNAaffects expression 20382639
C006253 pirinixic acid pirinixic acid results in increased expression of SSH2 mRNAincreases expression 18301758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.6418653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.2216434500
MESH:D000799 Angioedema Acetaminophen 4.7110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.3918445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.6319483382
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.413084413
MESH:D002386 Cataract Acetaminophen 2.8110977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 3.0120889678
MESH:D002779 Cholestasis pirinixic acid 3.1519176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5918249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6816177239 11461765 2444490 19416960 16227642 14725611 16485898 19085960 19370779 10915739 19923254 11287661 12958197 12705907 17562736 19739265 10663392 15968718 19164858 11739529 11421492 12540782 19420014 11743745 11529661 18071297 17522070 14550746 12153990 16781746 15619225 17906064 16109766 16081117 11834606 12392966 14986274 18713872 16393943 10774834 12594235
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.9619426721
MESH:D004487 Edema pirinixic acid 2.9612083418
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1520426865
MESH:D005234 Fatty Liver pirinixic acid 3.2519236843 20131406
MESH:D005756 Gastritis Acetaminophen 4.5416983495
MESH:D006333 Heart Failure pirinixic acid 2.7820558911
MESH:D006529 Hepatomegaly pirinixic acid 3.6416221962 19772884 18467677 19176532
MESH:D006930 Hyperalgesia Acetaminophen 3.0616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.6320558911
MESH:D007333 Insulin Resistance pirinixic acid 2.9016306350
MESH:D007674 Kidney Diseases Acetaminophen 2.4215629191 12587719
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.7116611625 19784758 12587719 19460945 12969438 19014921 16610002 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6816871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 1.9415890375 16377806 20007298
MESH:D008546 Melanoma, Experimental Acetaminophen 4.2219513568
MESH:D009135 Muscular Diseases pirinixic acid 4.1616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2916411023
MESH:D009369 Neoplasms pirinixic acid 2.1217405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2618514411
MESH:D009765 Obesity pirinixic acid 1.8920558911
MESH:D010146 Pain Acetaminophen 2.7716870215
MESH:D015427 Reperfusion Injury pirinixic acid 2.5619058328
MESH:D014581 Urticaria Acetaminophen 3.5010982225
Pathway ID Pathway Name
KEGG:04810 Regulation of actin cytoskeleton
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134861867
    • No data
    No data
    Releated drug ID Related drug Name
    PA449177cytarabine
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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