AutismKB 2.0

Annotation Detail for PIAS1


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Basic Information Top
Gene Symbol:PIAS1 ( DDXBP1,GBP,GU/RH-II,MGC141878,MGC141879,ZMIZ3 )
Gene Full Name: protein inhibitor of activated STAT, 1
Band: 15q23
Quick LinksEntrez ID:8554; OMIM: 603566; Uniprot ID:PIAS1_HUMAN; ENSEMBL ID: ENSG00000033800; HGNC ID: 2752
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05160Hepatitis C
hsa04630Jak-STAT signaling pathway
hsa04120Ubiquitin mediated proteolysis
hsa05222Small cell lung cancer
hsa05200Pathways in cancer
No data
Pathway IDPathway Name
200038Coregulation of Androgen receptor activity
200124IL6-mediated signaling events
200065Signaling events mediated by TCPTP
200097Sumoylation by RanBP2 regulates transcriptional repression
200147Hedgehog signaling events mediated by Gli proteins
200110IFN-gamma pathway
Pathway IDPathway Name
P00035Interferon-gamma signaling pathway
P00038JAK/STAT signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PIAS1 mRNAaffects expression 21346803
D001151 Arsenic Arsenic results in decreased expression of PIAS1 mRNAdecreases expression 16835338
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of PIAS1 mRNAaffects expression 17331233
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of PIAS1 mRNAdecreases expression 15336504
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PIAS1 mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in decreased expression of PIAS1 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PIAS1 mRNAaffects cotreatment|affects expression 17602206
D004958 Estradiol Estradiol promotes the reaction [PIAS1 protein binds to ESR1 protein]affects binding|increases reaction 15666801
D005576 Forskolin Forskolin results in decreased expression of PIAS1 mRNAdecreases expression 16751804
D005620 Freund's Adjuvant [Urethane co-treated with Freund's Adjuvant] results in increased expression of PIAS1 mRNAaffects cotreatment|increases expression 12400877
D015741 Metribolone Metribolone results in increased expression of PIAS1 mRNAincreases expression 16751804
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PIAS1 mRNAdecreases expression 20106945
D014520 Urethane [Urethane co-treated with Freund's Adjuvant] results in increased expression of PIAS1 mRNAaffects cotreatment|increases expression 12400877
D014810 Vitamin E Vitamin E results in decreased expression of PIAS1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9314514962 15322242 11752688
MESH:D000230 Adenocarcinoma Estradiol 4.8211473722
MESH:D000230 Adenocarcinoma Urethane 4.8218316556
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Urethane 5.8115814487
MESH:D000236 Adenoma Diethylnitrosamine 7.236695378 10737359
MESH:D000236 Adenoma Urethane 7.2310530776 6695378 11497255 16926031 17195641 10822126 17093202
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.3319052882 19061943 18056438 17162532 17620307 16434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.3316835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.3117306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D020261 Arsenic Poisoning marker/mechanism 16835338
MESH:D020261 Arsenic Poisoning Arsenic 2.8816251483 12569548 18414634 16835338
MESH:D050197 Atherosclerosis Arsenic 3.2819371607 12928151
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001862 Bone Resorption Freund's Adjuvant 5.1816769263
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8117474063
MESH:D001943 Breast Neoplasms Estradiol 1.8114630087 16675129 19861407 12948864 17289903 18497071 17018787 17261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8120435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5516111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0016050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6217687452 15504454
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.6616705839
MESH:D006528 Carcinoma, Hepatocellular Arsenic 6.6617306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.6620007298 17138121 21159647 17173139 20512989 20214788 16569478 16288022 20524982 19519916 17162532 16878318 18691550 17428255 20101231 16807293 19107877 17055752 19383236 20084675 19208518 19701751 16698587 18785209 16540662 16935385 16830150 19539802 20432363 3084413 16502159 17761372 18056438 11831363 18978308 19394651 16779866 17978847 16681979 20935162 20727157 19171122 18494052 19919837 19822196 18393292 16328049 18506893 18971187 20514400 3581430 18788625 19335982 10672840 18665156 18210153 10737359 19052882 19418558
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.6616924424
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7015504454 18922899 17687452
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.1318640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3918670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 3.4815738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.3618022660 16973168
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 16.326135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 16.3212371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 16.327505956 2727394 17174075 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 16.3218566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.4919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.4916835633
MESH:D002779 Cholestasis Cyclosporine 2.9519486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.2415668235 8697196 12621046 16354765 15340226
MESH:D002972 Cleft Palate Urethane 6.2412810352
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5010048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5019769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0918551238
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2617107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4619279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.2718551238 21346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.2719107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:C538011 Eales disease Vitamin E 4.809068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0018230668 15322242 16714409
MESH:D016889 Endometrial Neoplasms Estradiol 3.0118566989 19148513 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0710568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2116302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver Cyclosporine 7.9019224547
MESH:D005234 Fatty Liver Diethylnitrosamine 7.9021071580 20387270
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005355 Fibrosis Cyclosporine 8.7212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.7220067830
MESH:D005534 Foot Diseases Arsenic 5.666392382
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6610048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.6616080930
MESH:D006331 Heart Diseases Urethane 4.2716046796
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9615340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7216490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 5.1315709030
MESH:D019584 Hot Flashes Estradiol 10.3817088409
MESH:D019584 Hot Flashes Vitamin E 10.3814716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1416959395 18606429 16354765 15340226 8697196
MESH:D006930 Hyperalgesia Freund's Adjuvant 4.7216769263
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5117050553
MESH:D006973 Hypertension Arsenic 8.699931084 11953799 16076760
MESH:D006973 Hypertension Cyclosporine 8.6910903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.6918670907 18850075
MESH:D006987 Hypesthesia Arsenic 5.6616093927
MESH:D007249 Inflammation Diethylnitrosamine 8.6318785209
MESH:D007249 Inflammation Freund's Adjuvant 8.6316793879
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.6312878042 12200463
MESH:D007251 Influenza, Human Vitamin E 4.3116624496
MESH:D007333 Insulin Resistance Estradiol 3.0016627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007642 Keratosis Arsenic 5.0712749816 16930632
MESH:D007674 Kidney Diseases Cyclosporine 10.2318776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 10.2315618244
MESH:D007674 Kidney Diseases Vitamin E 10.2312488133
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.6416705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.6412371664
MESH:D007680 Kidney Neoplasms Estradiol 12.6415610895
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.5917339181
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8520032147 19638242 18522880 18407596 18665156
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.4814659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4812878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.4816169303
MESH:D008107 Liver Diseases Arsenic 4.2811134558
MESH:D008107 Liver Diseases Diethylnitrosamine 4.2817034775
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 18.267678174
MESH:D008113 Liver Neoplasms Arsenic 18.2616368122
MESH:D008113 Liver Neoplasms Clofibric Acid 18.2617602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 18.2612112319 19551842 20137499 19996281 19256749 19833225 19499222 21047994 19294768 20501860 19812893 18978307 18644402 19255062 19426721 20118626 10737359 21071580 12771043 15885732 19690152 19427195 9163691 19254457 19638242 2862719 21278145 18648771 20492335 18977376 20405173 20583210 20452335 19073162 18754104 19642983 2422723 19090486 21167192 20101389 20434301 19850985 15175105 16942905
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.2616984957
MESH:D008113 Liver Neoplasms Urethane 18.2616391232 17559639 17093202
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.982876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 9.982563599 18775883 3124819 17942915 19004024 18544905 16842330 18079962 19126423 19009564 18093689 16267830 19519916 19539802 21159647 17174075 18308698 18253720 18282651 18164116 9362446 17854601
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.9812151625
MESH:D008171 Lung Diseases Vitamin E 3.2116863852
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.0917365036
MESH:D008175 Lung Neoplasms Arsenic 6.6817976673 17306315 19168569
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.686695378 20512841 21163286 20970405
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.6819555203 11884234
MESH:D008175 Lung Neoplasms Urethane 6.6815902970 11497255 11992545 15136453 12957351 11893704 16788158 16391232 15166089 16289808 16926031 10779650 16204055 10822126 10530776 7750092 17093202 11552296 11062179 12466968 17255336 11246140 11323394 11544531 17195641 11074608 11807781 14587096 12765245 16337739 10997738 11307925 12117781 6695378 16007126
MESH:D008175 Lung Neoplasms Vitamin E 6.6811062179
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.5911408345 11807958 17203775 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.5819453300
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2018303189 16166281 16966607
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:D017202 Myocardial Ischemia Arsenic 9.1515371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.1512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3216810080
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.9418551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.599029167 3581430
MESH:D009369 Neoplasms Urethane 3.5315625555
MESH:D009374 Neoplasms, Experimental Urethane 4.7515582191
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8117289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3318481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 9.6816427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.6814600291
MESH:D009436 Neural Tube Defects Arsenic 3.4916620997
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.3920387270
MESH:D020078 Neurogenic Inflammation Arsenic 4.4317056641
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2120387270
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.4816049721
MESH:D010051 Ovarian Neoplasms Arsenic 8.1617306315
MESH:D010051 Ovarian Neoplasms Estradiol 8.1619401270
MESH:D010051 Ovarian Neoplasms Urethane 8.1616391232
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4416540662
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.2416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.0715371236 6392382 16905509
MESH:D010911 Pituitary Neoplasms Urethane 5.4816391232
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.9610923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.1012371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.102563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711118676 11896295 11222880 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9420887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.6016140617
MESH:D011471 Prostatic Neoplasms Estradiol 2.6016740699
MESH:D011471 Prostatic Neoplasms Vitamin E 2.6015084515
MESH:D011507 Proteinuria Arsenic 4.0621343184
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0517975199 17365031 15814490 17322281
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5718551238
MESH:D012871 Skin Diseases marker/mechanism 16835338
MESH:D012871 Skin Diseases Arsenic 5.0817938729 6392382 17453740 19834688 17050553 16353154 18709164 15952646 16759981 16702368 17548696
MESH:D012871 Skin Diseases Vitamin E 5.0818709164
MESH:D012878 Skin Neoplasms Arsenic 13.8417976673 16251483 15504454 17029826 19538983 17050553
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 13.848532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.8416192470
MESH:D012878 Skin Neoplasms Urethane 13.8411807781
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D020521 Stroke Vitamin E 3.5616517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.027505956
MESH:D013978 Tibial Fractures Estradiol 4.7819048282
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2716049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.2717976673 17306315 15987713 19429237 18640142 11144890 19322015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4010091137
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D014652 Vascular Diseases Arsenic 4.8217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D019043 Vascular Neoplasms Urethane 6.0110620525
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
Pathway ID Pathway Name
KEGG:05160 Hepatitis C
KEGG:04630 Jak-STAT signaling pathway
KEGG:05200 Pathways in cancer
REACT:6900 Signaling in Immune system
KEGG:05222 Small cell lung cancer
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33285
    • No data
    No data
    Releated drug ID Related drug Name
    PA450037interferon beta-1a
    PA450039interferon beta-1b
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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