AutismKB 2.0

Annotation Detail for CDC14B


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Basic Information Top
Gene Symbol:CDC14B ( CDC14B3,Cdc14B1,Cdc14B2,hCDC14B )
Gene Full Name: CDC14 cell division cycle 14 homolog B (S. cerevisiae)
Band: 9q22.32-q22.33
Quick LinksEntrez ID:8555; OMIM: 603505; Uniprot ID:CC14B_HUMAN; ENSEMBL ID: ENSG00000081377; HGNC ID: 1719
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04110Cell cycle
No data
Pathway IDPathway Name
200087PLK1 signaling events
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of CDC14B mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of CDC14B mRNAdecreases expression 19420014
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of CDC14B mRNAincreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CDC14B mRNAdecreases expression 19150397
D003474 Curcumin Curcumin results in increased expression of CDC14B mRNAincreases expression 17198877
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of CDC14B mRNAaffects cotreatment|increases expression 17404688
C008493 methylselenic acid methylselenic acid affects the expression of CDC14B mRNAaffects expression 14617803
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CDC14B mRNAaffects binding|decreases expression|increases activity 19710929
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of CDC14B mRNAaffects cotreatment|increases expression 17404688
D011374 Progesterone Progesterone results in increased expression of CDC14B mRNAincreases expression 17404688
D012643 Selenium Selenium results in decreased expression of CDC14B mRNAdecreases expression 19244175
D018038 Sodium Selenite Sodium Selenite results in decreased expression of CDC14B mRNAdecreases expression 18175754
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CDC14B mRNAincreases expression 20106945
D014810 Vitamin E Vitamin E results in decreased expression of CDC14B mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0014514962 11752688 15322242
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3720127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.3711473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.716695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.4216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4216835633
MESH:D019973 Alcohol-Related Disorders Curcumin 5.2617887948
MESH:D000544 Alzheimer Disease Curcumin 2.6415590663
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7616807698
MESH:D050197 Atherosclerosis Curcumin 3.3818704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001327 Autoimmune Diseases Curcumin 4.6319761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.1419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.1412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.5117868700
MESH:D001930 Brain Injuries Progesterone 4.4015845082 15380490 15665606
MESH:D002545 Brain Ischemia Curcumin 4.4816770732
MESH:D001932 Brain Neoplasms Curcumin 4.0417596214
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3617474063 20146248
MESH:D001943 Breast Neoplasms Curcumin 2.3618593918 18462866 19250217 16243823
MESH:D001943 Breast Neoplasms Estradiol 2.3617261762 12948864 19861407 17018787 14630087 18497071 16675129 17289903
MESH:D001943 Breast Neoplasms Progesterone 2.3616175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3620435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6216111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0716050911
MESH:D002277 Carcinoma Curcumin 8.5818593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.5816835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.863084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 2.8616924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0118414057
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8420419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 4.8418462866
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4216120746 18850075 18670907
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.8920889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.8918566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis pirinixic acid 2.9119176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8915894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.148697196 12621046 15340226 16354765 15668235
MESH:D003092 Colitis Curcumin 10.1418200517 16782535 16804969
MESH:D003092 Colitis Selenium 10.1417936198
MESH:D003103 Coloboma Curcumin 4.6618809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5216340194 19359593
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 5.0318497527
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5115322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5119769572
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8716285004
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.4918403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4917107852
MESH:D003928 Diabetic Nephropathies Curcumin 9.3618204486
MESH:D003928 Diabetic Nephropathies Estradiol 9.3619279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.6317187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.2210915739 19420014 19085960 15619225 12958197 16109766 11287661 11739529 12705907 16393943 11421492 12392966 17522070 16081117 18071297 2444490 16781746 10774834 17906064 16485898 14725611 12594235 16227642 19370779 11834606 16177239 15968718 11743745 14986274 19164858 11529661 19923254 10663392 17562736 19416960 12540782 12153990 14550746 18713872 19739265 11461765
MESH:D056486 Drug-Induced Liver Injury Selenium 9.2215131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.2215131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.2220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004381 Duodenal Ulcer Curcumin 4.1717351913
MESH:C538011 Eales disease Vitamin E 4.889068938
MESH:D004487 Edema pirinixic acid 6.9012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.9012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0815322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.9117692515
MESH:D016889 Endometrial Neoplasms Estradiol 3.0511473722 19148513 18566989
MESH:D004715 Endometriosis Progesterone 9.2816134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.289294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4320426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4316530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Curcumin 8.2419297423
MESH:D005234 Fatty Liver pirinixic acid 8.2419236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005355 Fibrosis Curcumin 9.2618705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2620067830
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.8318462866
MESH:D005909 Glioblastoma Curcumin 3.5417596214
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006258 Head and Neck Neoplasms Curcumin 3.7318829502 18462866
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.4220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.4210048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 11.4216080930
MESH:D006333 Heart Failure pirinixic acid 7.1720558911
MESH:D006333 Heart Failure Selenium 7.1717162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly pirinixic acid 8.7319772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.7312621046 15340226 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.1817701891
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 5.2115709030
MESH:D019584 Hot Flashes Estradiol 10.6417088409
MESH:D019584 Hot Flashes Vitamin E 10.6414716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2218606429 15340226 16354765 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006937 Hypercholesterolemia Curcumin 4.1618704882
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9418850075 18670907
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5415869954
MESH:D007249 Inflammation Curcumin 8.6918403477 16956363 17151092
MESH:D007249 Inflammation Progesterone 8.6915869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.6912878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.2518200517 18596194
MESH:D007251 Influenza, Human Selenium 11.5516624496
MESH:D007251 Influenza, Human Vitamin E 11.5516624496
MESH:D007333 Insulin Resistance Estradiol 12.7216627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 12.7216306350
MESH:D007333 Insulin Resistance Sodium Selenite 12.7214714311
MESH:D007414 Intestinal Neoplasms Curcumin 4.3210783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007674 Kidney Diseases Acetaminophen 10.3915629191 12587719
MESH:D007674 Kidney Diseases Estradiol 10.3915618244
MESH:D007674 Kidney Diseases Vitamin E 10.3912488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9916518626
MESH:D007680 Kidney Neoplasms Estradiol 3.0715610895
MESH:D007889 Leiomyoma Curcumin 4.6918555241
MESH:D007938 Leukemia Curcumin 3.2918462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.3116106398
MESH:D015458 Leukemia, T-Cell Curcumin 4.8916106398
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 6.8617355460 18006644 18705752
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.8614716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.8615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.8612878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.8616169303
MESH:D008107 Liver Diseases Acetaminophen 4.1819460945 16611625 19784758 12587719 12969438 11587558 19014921 16610002
MESH:D008107 Liver Diseases Curcumin 4.1816956363
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3416871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.5321137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 7.5316377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.5316984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1712151625
MESH:D008171 Lung Diseases Vitamin E 3.2516863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.956695378 18569708 17053015 18816296 20464547 20869020 20135361 20064080 18520028
MESH:D008175 Lung Neoplasms Curcumin 4.9516243823 19359593 18462866
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9519555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 4.9511062179
MESH:D008223 Lymphoma Curcumin 3.6618462866
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1814737004
MESH:D016399 Lymphoma, T-Cell Curcumin 4.8316173963
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.3911408345 16891317 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 10.3911408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Selenium 10.3915318939
MESH:D020149 Manganese Poisoning Estradiol 4.6619453300
MESH:D008545 Melanoma Curcumin 2.4318462866 17885582
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008569 Memory Disorders Curcumin 4.2817263510
MESH:D008654 Mesothelioma Selenium 2.8315107826
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D009101 Multiple Myeloma Curcumin 3.5919372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.0717962980
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.5316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.5316411023
MESH:D009361 Neoplasm Invasiveness Curcumin 4.5018495463
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9911141357
MESH:D009369 Neoplasms pirinixic acid 4.9917405874
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.7112497104
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8917289903
MESH:D009421 Nervous System Malformations Estradiol 9.8911399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.8914600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.8018462866
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D009765 Obesity Curcumin 4.6819297423
MESH:D009765 Obesity pirinixic acid 4.6820558911
MESH:D010024 Osteoporosis Curcumin 3.5318719352
MESH:D010051 Ovarian Neoplasms Curcumin 8.1318462866 19020741
MESH:D010051 Ovarian Neoplasms Estradiol 8.1319401270
MESH:D010051 Ovarian Neoplasms Progesterone 8.1316525653 17393432
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D010190 Pancreatic Neoplasms Curcumin 2.9717440100 19401701 19196508
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D010954 Plasmacytoma Selenium 5.0615087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411896295 11118676 11222880 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.9017292933
MESH:D011471 Prostatic Neoplasms Curcumin 1.9010851300 12497104 11398177 18769126 15129424 18226269 18156803
MESH:D011471 Prostatic Neoplasms Estradiol 1.9016740699
MESH:D011471 Prostatic Neoplasms methylselenic acid 1.9016205645
MESH:D011471 Prostatic Neoplasms Sodium Selenite 1.9018760546
MESH:D011471 Prostatic Neoplasms Vitamin E 1.9015084515
MESH:D011656 Pulmonary Emphysema Curcumin 4.6319168576
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.1418379247 10666014
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8918045962
MESH:D012509 Sarcoma Curcumin 4.2218462866
MESH:D018805 Sepsis Curcumin 4.1718389075
MESH:D012871 Skin Diseases Vitamin E 2.4618709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.6319755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6316192470
MESH:D013119 Spinal Cord Injuries Progesterone 4.4316503802 15862959
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013276 Stomach Ulcer Curcumin 3.6019188055 16631530
MESH:D020521 Stroke Vitamin E 3.6116517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013978 Tibial Fractures Estradiol 4.8619048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3217053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 5.3218593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.4218462866
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
Pathway ID Pathway Name
KEGG:04110 Cell cycle
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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