AutismKB 2.0

Annotation Detail for PRPF18


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Basic Information Top
Gene Symbol:PRPF18 ( FLJ10210,PRP18,hPrp18 )
Gene Full Name: PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae)
Band: 10p13
Quick LinksEntrez ID:8559; OMIM: 604993; Uniprot ID:PRP18_HUMAN; ENSEMBL ID: ENSG00000165630; HGNC ID: 17351
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PRPF18 mRNAaffects expression 16483693
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in increased expression of PRPF18 mRNAincreases expression 17553608
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PRPF18 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRPF18 mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil Fluorouracil results in decreased expression of PRPF18 mRNAdecreases expression 16101138
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of PRPF18 mRNAaffects cotreatment|increases expression 17183730
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRPF18 mRNAaffects cotreatment|increases expression 17942748
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of PRPF18 mRNAaffects cotreatment|increases expression 17183730
D014810 Vitamin E Vitamin E results in decreased expression of PRPF18 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.4611752688 14514962 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.468875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1719490988
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.5114692618
MESH:D000230 Adenocarcinoma Fluorouracil 4.5117638652
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000550 Amblyopia Valproic Acid 5.6117688650
MESH:D000740 Anemia Fluorouracil 9.4515504547 16511603 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.4511748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.7617497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001321 Autistic Disorder Valproic Acid 1.9918940202 17507914 19232924 18316065 18396377 18985861 17157402 15238991 18775368 18558336 19460635 18177632 16609825 20603192 17688650
MESH:D001714 Bipolar Disorder Valproic Acid 3.1820046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.5015746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.508888407
MESH:D001943 Breast Neoplasms Fluorouracil 2.0319217205 18608205 16557594 16110121 15136595 18357371 16595493
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0320435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.2416050911
MESH:D002276 Carcinoid Tumor Fluorouracil 5.0416051944
MESH:D002277 Carcinoma Fluorouracil 8.8317121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.8316835633
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 2.1117088986 16332177 16799960 17971768 17045692 18930000
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1118695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5516280240 16757204 18986760 17066447
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918850075 16120746 18670907
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7820734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0517333356 17681005 17110522 15861022 11677210 16105132 16919318
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1916354765 8697196 12621046 15340226 15668235
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2618772588 15001691 17169374 17725105 17016597 16510598 17172411 16340194 17018589 17287894
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017016601 16282729 17255274 18383874 17094418 20501625 18949393 17695437 18288408 17454858 17401013 16524972 16331619 18509181 14970324 18802399 17594712 16303861 15289873 15148649 18448328 16391804
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8915322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.898888407 17688650 16575769
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8919769572
MESH:D007644 Darier Disease Fluorouracil 5.1316733453
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9720420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 3.9719641884 1733752
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004421 Dystonia Valproic Acid 4.311851702
MESH:C538011 Eales disease Vitamin E 5.089068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2816714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4712538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.259294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.4617275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.293922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0420417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.806254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.607750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.403659116
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.5016481741 16337965 16785472 15173087 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.5615345470
MESH:D005234 Fatty Liver Valproic Acid 8.5619224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005315 Fetal Diseases Valproic Acid 5.2616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.418888407 18558336
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2520067830
MESH:D005910 Glioma Fluorouracil 2.9516145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5415102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9510048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.9516080930
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2015340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7716863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.3514716179
MESH:D006849 Hydrocephalus Valproic Acid 5.2017688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4216354765 15340226 8697196 18606429 16959395
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.9316612254
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9612200463 12878042
MESH:D007251 Influenza, Human Vitamin E 4.5916624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007674 Kidney Diseases Vitamin E 2.9312488133
MESH:D007680 Kidney Neoplasms Fluorouracil 3.5116985049
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1817596541 16294345
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.4012878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4016169303
MESH:D008113 Liver Neoplasms Fluorouracil 4.7516603448 15113037 17045692 18383874
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7516984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2412151625
MESH:D008171 Lung Diseases Vitamin E 3.3316863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.6417228818
MESH:D008175 Lung Neoplasms Fluorouracil 3.5515246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5511884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 3.5511062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.1315086387
MESH:D008881 Migraine Disorders Valproic Acid 3.3618803445 18765137
MESH:D009062 Mouth Neoplasms Fluorouracil 3.8118986760 16757204
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.278888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2817596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D009369 Neoplasms Fluorouracil 2.7118600527 16928823 18239605
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.2716359493 8888407
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5916436463
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7316500647 16929163 19003803 15113037
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.6111118676 11222880 11896295 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.6120603192
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3019082440 18626508
MESH:D011471 Prostatic Neoplasms Vitamin E 3.3015084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.6516919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.9212752131 11422049
MESH:D012004 Rectal Neoplasms Fluorouracil 4.2315538739 16160472 18286688 18722050
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4419155313
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.8916876388 14763951 15475178 11044598 17978042 3137016 11738929 1511512
MESH:D012871 Skin Diseases Vitamin E 2.4918709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9212833885
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0017522103 19015929 16951190 17172411 18396642 16424979 15786421 18567086 17498489 19084572
MESH:D020521 Stroke Vitamin E 3.7116517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D014062 Tongue Neoplasms Fluorouracil 4.2216280240
MESH:D014178 Translocation, Genetic Valproic Acid 5.6117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.863119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.958888407
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.1116803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
Pathway ID Pathway Name
KEGG:03040 Spliceosome
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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